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New Antibacterial Phenone Derivatives Asperphenone A–C from Mangrove-Derived Fungus Aspergillus sp. YHZ-1
Marine fungi are a promising source of novel bioactive natural products with diverse structure. In our search for new bioactive natural products from marine fungi, three new phenone derivatives, asperphenone A–C (1–3), have been isolated from the ethyl acetate extract of the fermentation broth of th...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852473/ https://www.ncbi.nlm.nih.gov/pubmed/29385686 http://dx.doi.org/10.3390/md16020045 |
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author | Guo, Zhi-Kai Zhou, Yi-Qin Han, Hao Wang, Wen Xiang, Lang Deng, Xin-Zhao Ge, Hui-Ming Jiao, Rui-Hua |
author_facet | Guo, Zhi-Kai Zhou, Yi-Qin Han, Hao Wang, Wen Xiang, Lang Deng, Xin-Zhao Ge, Hui-Ming Jiao, Rui-Hua |
author_sort | Guo, Zhi-Kai |
collection | PubMed |
description | Marine fungi are a promising source of novel bioactive natural products with diverse structure. In our search for new bioactive natural products from marine fungi, three new phenone derivatives, asperphenone A–C (1–3), have been isolated from the ethyl acetate extract of the fermentation broth of the mangrove-derived fungus, Aspergillus sp. YHZ-1. The chemical structures of these natural products were elucidated on the basis of mass spectrometry, one- and two-dimensional NMR spectroscopic analysis and asperphenone A and B were confirmed by single-crystal X-ray crystallography. Compounds 1 and 2 exhibited weak antibacterial activity against four Gram-positive bacteria, Staphylococcus aureus CMCC(B) 26003, Streptococcus pyogenes ATCC19615, Bacillus subtilis CICC 10283 and Micrococcus luteus, with the MIC values higher than 32.0 µM. |
format | Online Article Text |
id | pubmed-5852473 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-58524732018-03-19 New Antibacterial Phenone Derivatives Asperphenone A–C from Mangrove-Derived Fungus Aspergillus sp. YHZ-1 Guo, Zhi-Kai Zhou, Yi-Qin Han, Hao Wang, Wen Xiang, Lang Deng, Xin-Zhao Ge, Hui-Ming Jiao, Rui-Hua Mar Drugs Article Marine fungi are a promising source of novel bioactive natural products with diverse structure. In our search for new bioactive natural products from marine fungi, three new phenone derivatives, asperphenone A–C (1–3), have been isolated from the ethyl acetate extract of the fermentation broth of the mangrove-derived fungus, Aspergillus sp. YHZ-1. The chemical structures of these natural products were elucidated on the basis of mass spectrometry, one- and two-dimensional NMR spectroscopic analysis and asperphenone A and B were confirmed by single-crystal X-ray crystallography. Compounds 1 and 2 exhibited weak antibacterial activity against four Gram-positive bacteria, Staphylococcus aureus CMCC(B) 26003, Streptococcus pyogenes ATCC19615, Bacillus subtilis CICC 10283 and Micrococcus luteus, with the MIC values higher than 32.0 µM. MDPI 2018-01-30 /pmc/articles/PMC5852473/ /pubmed/29385686 http://dx.doi.org/10.3390/md16020045 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Guo, Zhi-Kai Zhou, Yi-Qin Han, Hao Wang, Wen Xiang, Lang Deng, Xin-Zhao Ge, Hui-Ming Jiao, Rui-Hua New Antibacterial Phenone Derivatives Asperphenone A–C from Mangrove-Derived Fungus Aspergillus sp. YHZ-1 |
title | New Antibacterial Phenone Derivatives Asperphenone A–C from Mangrove-Derived Fungus Aspergillus sp. YHZ-1 |
title_full | New Antibacterial Phenone Derivatives Asperphenone A–C from Mangrove-Derived Fungus Aspergillus sp. YHZ-1 |
title_fullStr | New Antibacterial Phenone Derivatives Asperphenone A–C from Mangrove-Derived Fungus Aspergillus sp. YHZ-1 |
title_full_unstemmed | New Antibacterial Phenone Derivatives Asperphenone A–C from Mangrove-Derived Fungus Aspergillus sp. YHZ-1 |
title_short | New Antibacterial Phenone Derivatives Asperphenone A–C from Mangrove-Derived Fungus Aspergillus sp. YHZ-1 |
title_sort | new antibacterial phenone derivatives asperphenone a–c from mangrove-derived fungus aspergillus sp. yhz-1 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852473/ https://www.ncbi.nlm.nih.gov/pubmed/29385686 http://dx.doi.org/10.3390/md16020045 |
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