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The Anti-Cancer Effects of Frondoside A

Frondoside A is a triterpenoid glycoside from the Atlantic Sea Cucumber, Cucumaria frondosa. Frondoside A has a broad spectrum of anti-cancer effects, including induction of cellular apoptosis, inhibition of cancer cell growth, migration, invasion, formation of metastases, and angiogenesis. In cell...

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Detalles Bibliográficos
Autores principales: Adrian, Thomas E., Collin, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852492/
https://www.ncbi.nlm.nih.gov/pubmed/29463049
http://dx.doi.org/10.3390/md16020064
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author Adrian, Thomas E.
Collin, Peter
author_facet Adrian, Thomas E.
Collin, Peter
author_sort Adrian, Thomas E.
collection PubMed
description Frondoside A is a triterpenoid glycoside from the Atlantic Sea Cucumber, Cucumaria frondosa. Frondoside A has a broad spectrum of anti-cancer effects, including induction of cellular apoptosis, inhibition of cancer cell growth, migration, invasion, formation of metastases, and angiogenesis. In cell lines and animal models studied to date, the anti-cancer effects of the compound are seen in all solid cancers, lymphomas, and leukemias studied to date. These effects appear to be due to potent inhibition of p21-activated kinase 1 (PAK1), which is up-regulated in many cancers. In mouse models, frondoside A has synergistic effects with conventional chemotherapeutic agents, such as gemcitabine, paclitaxel, and cisplatin. Frondoside A administration is well-tolerated. No side effects have been reported and the compound has no significant effects on body weight, blood cells, or on hepatic and renal function tests after long-term administration. Frondoside A may be valuable in the treatment of malignancies, either as a single agent or in combination with other therapeutic modalities.
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spelling pubmed-58524922018-03-19 The Anti-Cancer Effects of Frondoside A Adrian, Thomas E. Collin, Peter Mar Drugs Review Frondoside A is a triterpenoid glycoside from the Atlantic Sea Cucumber, Cucumaria frondosa. Frondoside A has a broad spectrum of anti-cancer effects, including induction of cellular apoptosis, inhibition of cancer cell growth, migration, invasion, formation of metastases, and angiogenesis. In cell lines and animal models studied to date, the anti-cancer effects of the compound are seen in all solid cancers, lymphomas, and leukemias studied to date. These effects appear to be due to potent inhibition of p21-activated kinase 1 (PAK1), which is up-regulated in many cancers. In mouse models, frondoside A has synergistic effects with conventional chemotherapeutic agents, such as gemcitabine, paclitaxel, and cisplatin. Frondoside A administration is well-tolerated. No side effects have been reported and the compound has no significant effects on body weight, blood cells, or on hepatic and renal function tests after long-term administration. Frondoside A may be valuable in the treatment of malignancies, either as a single agent or in combination with other therapeutic modalities. MDPI 2018-02-19 /pmc/articles/PMC5852492/ /pubmed/29463049 http://dx.doi.org/10.3390/md16020064 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Adrian, Thomas E.
Collin, Peter
The Anti-Cancer Effects of Frondoside A
title The Anti-Cancer Effects of Frondoside A
title_full The Anti-Cancer Effects of Frondoside A
title_fullStr The Anti-Cancer Effects of Frondoside A
title_full_unstemmed The Anti-Cancer Effects of Frondoside A
title_short The Anti-Cancer Effects of Frondoside A
title_sort anti-cancer effects of frondoside a
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852492/
https://www.ncbi.nlm.nih.gov/pubmed/29463049
http://dx.doi.org/10.3390/md16020064
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