Cladodionen, a Cytotoxic Hybrid Polyketide from the Marine-Derived Cladosporium sp. OUCMDZ-1635

A new hybrid polyketide, cladodionen (1), together with a new abscisic acid analogue, cladosacid (2), were isolated from the marine-derived fungus, Cladosporium sp. OUCMDZ-1635. Their structures, including the absolute configurations, were fully elucidated on the basis of spectroscopic analysis, ECD...

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Detalles Bibliográficos
Autores principales: Zhu, Guoliang, Kong, Fandong, Wang, Yi, Fu, Peng, Zhu, Weiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852499/
https://www.ncbi.nlm.nih.gov/pubmed/29470403
http://dx.doi.org/10.3390/md16020071
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author Zhu, Guoliang
Kong, Fandong
Wang, Yi
Fu, Peng
Zhu, Weiming
author_facet Zhu, Guoliang
Kong, Fandong
Wang, Yi
Fu, Peng
Zhu, Weiming
author_sort Zhu, Guoliang
collection PubMed
description A new hybrid polyketide, cladodionen (1), together with a new abscisic acid analogue, cladosacid (2), were isolated from the marine-derived fungus, Cladosporium sp. OUCMDZ-1635. Their structures, including the absolute configurations, were fully elucidated on the basis of spectroscopic analysis, ECD spectra, quantum chemical calculations, and chemical methods. Cladodionen (1) showed cytotoxic activities against MCF-7, HeLa, HCT-116, and HL-60 human cancer cell lines with IC(50) values of 18.7, 19.1, 17.9, and 9.1 µM.
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spelling pubmed-58524992018-03-19 Cladodionen, a Cytotoxic Hybrid Polyketide from the Marine-Derived Cladosporium sp. OUCMDZ-1635 Zhu, Guoliang Kong, Fandong Wang, Yi Fu, Peng Zhu, Weiming Mar Drugs Communication A new hybrid polyketide, cladodionen (1), together with a new abscisic acid analogue, cladosacid (2), were isolated from the marine-derived fungus, Cladosporium sp. OUCMDZ-1635. Their structures, including the absolute configurations, were fully elucidated on the basis of spectroscopic analysis, ECD spectra, quantum chemical calculations, and chemical methods. Cladodionen (1) showed cytotoxic activities against MCF-7, HeLa, HCT-116, and HL-60 human cancer cell lines with IC(50) values of 18.7, 19.1, 17.9, and 9.1 µM. MDPI 2018-02-22 /pmc/articles/PMC5852499/ /pubmed/29470403 http://dx.doi.org/10.3390/md16020071 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Zhu, Guoliang
Kong, Fandong
Wang, Yi
Fu, Peng
Zhu, Weiming
Cladodionen, a Cytotoxic Hybrid Polyketide from the Marine-Derived Cladosporium sp. OUCMDZ-1635
title Cladodionen, a Cytotoxic Hybrid Polyketide from the Marine-Derived Cladosporium sp. OUCMDZ-1635
title_full Cladodionen, a Cytotoxic Hybrid Polyketide from the Marine-Derived Cladosporium sp. OUCMDZ-1635
title_fullStr Cladodionen, a Cytotoxic Hybrid Polyketide from the Marine-Derived Cladosporium sp. OUCMDZ-1635
title_full_unstemmed Cladodionen, a Cytotoxic Hybrid Polyketide from the Marine-Derived Cladosporium sp. OUCMDZ-1635
title_short Cladodionen, a Cytotoxic Hybrid Polyketide from the Marine-Derived Cladosporium sp. OUCMDZ-1635
title_sort cladodionen, a cytotoxic hybrid polyketide from the marine-derived cladosporium sp. oucmdz-1635
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852499/
https://www.ncbi.nlm.nih.gov/pubmed/29470403
http://dx.doi.org/10.3390/md16020071
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