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Renal Tubule Repair: Is Wnt/β-Catenin a Friend or Foe?

Wnt/β-catenin signaling is extremely important for proper kidney development. This pathway is also upregulated in injured renal tubular epithelia, both in acute kidney injury and chronic kidney disease. The renal tubular epithelium is an important target of kidney injury, and its response (repair ve...

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Detalles Bibliográficos
Autor principal: Gewin, Leslie S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852554/
https://www.ncbi.nlm.nih.gov/pubmed/29364168
http://dx.doi.org/10.3390/genes9020058
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author_facet Gewin, Leslie S.
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description Wnt/β-catenin signaling is extremely important for proper kidney development. This pathway is also upregulated in injured renal tubular epithelia, both in acute kidney injury and chronic kidney disease. The renal tubular epithelium is an important target of kidney injury, and its response (repair versus persistent injury) is critical for determining whether tubulointerstitial fibrosis, the hallmark of chronic kidney disease, develops. This review discusses how Wnt/β-catenin signaling in the injured tubular epithelia promotes either repair or fibrosis after kidney injury. There is data suggesting that epithelial Wnt/β-catenin signaling is beneficial in acute kidney injury and important in tubular progenitors responsible for epithelial repair. The role of Wnt/β-catenin signaling in chronically injured epithelia is less clear. There is convincing data that Wnt/β-catenin signaling in interstitial fibroblasts and pericytes contributes to the extracellular matrix accumulation that defines fibrosis. However, some recent studies question whether Wnt/β-catenin signaling in chronically injured epithelia actually promotes fibrosis or repair.
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spelling pubmed-58525542018-03-19 Renal Tubule Repair: Is Wnt/β-Catenin a Friend or Foe? Gewin, Leslie S. Genes (Basel) Review Wnt/β-catenin signaling is extremely important for proper kidney development. This pathway is also upregulated in injured renal tubular epithelia, both in acute kidney injury and chronic kidney disease. The renal tubular epithelium is an important target of kidney injury, and its response (repair versus persistent injury) is critical for determining whether tubulointerstitial fibrosis, the hallmark of chronic kidney disease, develops. This review discusses how Wnt/β-catenin signaling in the injured tubular epithelia promotes either repair or fibrosis after kidney injury. There is data suggesting that epithelial Wnt/β-catenin signaling is beneficial in acute kidney injury and important in tubular progenitors responsible for epithelial repair. The role of Wnt/β-catenin signaling in chronically injured epithelia is less clear. There is convincing data that Wnt/β-catenin signaling in interstitial fibroblasts and pericytes contributes to the extracellular matrix accumulation that defines fibrosis. However, some recent studies question whether Wnt/β-catenin signaling in chronically injured epithelia actually promotes fibrosis or repair. MDPI 2018-01-24 /pmc/articles/PMC5852554/ /pubmed/29364168 http://dx.doi.org/10.3390/genes9020058 Text en © 2018 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gewin, Leslie S.
Renal Tubule Repair: Is Wnt/β-Catenin a Friend or Foe?
title Renal Tubule Repair: Is Wnt/β-Catenin a Friend or Foe?
title_full Renal Tubule Repair: Is Wnt/β-Catenin a Friend or Foe?
title_fullStr Renal Tubule Repair: Is Wnt/β-Catenin a Friend or Foe?
title_full_unstemmed Renal Tubule Repair: Is Wnt/β-Catenin a Friend or Foe?
title_short Renal Tubule Repair: Is Wnt/β-Catenin a Friend or Foe?
title_sort renal tubule repair: is wnt/β-catenin a friend or foe?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852554/
https://www.ncbi.nlm.nih.gov/pubmed/29364168
http://dx.doi.org/10.3390/genes9020058
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