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Maternal Vitamin D Status and Infant Infection
Maternal vitamin D status during pregnancy may modulate fetal immune system development and infant susceptibility to infections. Vitamin D deficiency is common during pregnancy, particularly among African American (AA) women. Our objective was to compare maternal vitamin D status (plasma 25(OH)D con...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852687/ https://www.ncbi.nlm.nih.gov/pubmed/29360733 http://dx.doi.org/10.3390/nu10020111 |
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author | Moukarzel, Sara Ozias, Marlies Kerling, Elizabeth Christifano, Danielle Wick, Jo Colombo, John Carlson, Susan |
author_facet | Moukarzel, Sara Ozias, Marlies Kerling, Elizabeth Christifano, Danielle Wick, Jo Colombo, John Carlson, Susan |
author_sort | Moukarzel, Sara |
collection | PubMed |
description | Maternal vitamin D status during pregnancy may modulate fetal immune system development and infant susceptibility to infections. Vitamin D deficiency is common during pregnancy, particularly among African American (AA) women. Our objective was to compare maternal vitamin D status (plasma 25(OH)D concentration) during pregnancy and first-year infections in the offspring of African American (AA) and non-AA women. We used medical records to record frequency and type of infections during the first year of life of 220 term infants (69 AA, 151 non-AA) whose mothers participated in the Kansas University DHA Outcomes Study. AA and non-AA groups were compared for maternal 25(OH)D by Mann–Whitney U-test. Compared to non-AA women, AA women were more likely to be vitamin D deficient (<50 nmol/L; 84 vs. 37%, p < 0.001), and more of their infants had at least one infection in the first 6 months (78.3% and 59.6% of infants, respectively, p = 0.022). We next explored the relationship between maternal plasma 25(OH)D concentration and infant infections using Spearman correlations. Maternal 25(OH)D concentration was inversely correlated with the number of all infections (p = 0.033), eye, ear, nose, and throat (EENT) infections (p = 0.043), and skin infection (p = 0.021) in the first 6 months. A model that included maternal education, income, and 25(OH)D identified maternal education as the only significant predictor of infection risk in the first 6 months (p = 0.045); however, maternal education, income, and 25(OH)D were all significantly lower in AA women compared to non-AA women . The high degree of correlation between these variables does not allow determination of which factor is driving the risk of infection; however, the one that is most easily remediated is vitamin D status. It would be of value to learn if vitamin D supplementation in this at-risk group could ameliorate at least part of the increased infection risk. |
format | Online Article Text |
id | pubmed-5852687 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-58526872018-03-19 Maternal Vitamin D Status and Infant Infection Moukarzel, Sara Ozias, Marlies Kerling, Elizabeth Christifano, Danielle Wick, Jo Colombo, John Carlson, Susan Nutrients Article Maternal vitamin D status during pregnancy may modulate fetal immune system development and infant susceptibility to infections. Vitamin D deficiency is common during pregnancy, particularly among African American (AA) women. Our objective was to compare maternal vitamin D status (plasma 25(OH)D concentration) during pregnancy and first-year infections in the offspring of African American (AA) and non-AA women. We used medical records to record frequency and type of infections during the first year of life of 220 term infants (69 AA, 151 non-AA) whose mothers participated in the Kansas University DHA Outcomes Study. AA and non-AA groups were compared for maternal 25(OH)D by Mann–Whitney U-test. Compared to non-AA women, AA women were more likely to be vitamin D deficient (<50 nmol/L; 84 vs. 37%, p < 0.001), and more of their infants had at least one infection in the first 6 months (78.3% and 59.6% of infants, respectively, p = 0.022). We next explored the relationship between maternal plasma 25(OH)D concentration and infant infections using Spearman correlations. Maternal 25(OH)D concentration was inversely correlated with the number of all infections (p = 0.033), eye, ear, nose, and throat (EENT) infections (p = 0.043), and skin infection (p = 0.021) in the first 6 months. A model that included maternal education, income, and 25(OH)D identified maternal education as the only significant predictor of infection risk in the first 6 months (p = 0.045); however, maternal education, income, and 25(OH)D were all significantly lower in AA women compared to non-AA women . The high degree of correlation between these variables does not allow determination of which factor is driving the risk of infection; however, the one that is most easily remediated is vitamin D status. It would be of value to learn if vitamin D supplementation in this at-risk group could ameliorate at least part of the increased infection risk. MDPI 2018-01-23 /pmc/articles/PMC5852687/ /pubmed/29360733 http://dx.doi.org/10.3390/nu10020111 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Moukarzel, Sara Ozias, Marlies Kerling, Elizabeth Christifano, Danielle Wick, Jo Colombo, John Carlson, Susan Maternal Vitamin D Status and Infant Infection |
title | Maternal Vitamin D Status and Infant Infection |
title_full | Maternal Vitamin D Status and Infant Infection |
title_fullStr | Maternal Vitamin D Status and Infant Infection |
title_full_unstemmed | Maternal Vitamin D Status and Infant Infection |
title_short | Maternal Vitamin D Status and Infant Infection |
title_sort | maternal vitamin d status and infant infection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852687/ https://www.ncbi.nlm.nih.gov/pubmed/29360733 http://dx.doi.org/10.3390/nu10020111 |
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