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Maternal Vitamin D Status and Infant Infection

Maternal vitamin D status during pregnancy may modulate fetal immune system development and infant susceptibility to infections. Vitamin D deficiency is common during pregnancy, particularly among African American (AA) women. Our objective was to compare maternal vitamin D status (plasma 25(OH)D con...

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Autores principales: Moukarzel, Sara, Ozias, Marlies, Kerling, Elizabeth, Christifano, Danielle, Wick, Jo, Colombo, John, Carlson, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852687/
https://www.ncbi.nlm.nih.gov/pubmed/29360733
http://dx.doi.org/10.3390/nu10020111
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author Moukarzel, Sara
Ozias, Marlies
Kerling, Elizabeth
Christifano, Danielle
Wick, Jo
Colombo, John
Carlson, Susan
author_facet Moukarzel, Sara
Ozias, Marlies
Kerling, Elizabeth
Christifano, Danielle
Wick, Jo
Colombo, John
Carlson, Susan
author_sort Moukarzel, Sara
collection PubMed
description Maternal vitamin D status during pregnancy may modulate fetal immune system development and infant susceptibility to infections. Vitamin D deficiency is common during pregnancy, particularly among African American (AA) women. Our objective was to compare maternal vitamin D status (plasma 25(OH)D concentration) during pregnancy and first-year infections in the offspring of African American (AA) and non-AA women. We used medical records to record frequency and type of infections during the first year of life of 220 term infants (69 AA, 151 non-AA) whose mothers participated in the Kansas University DHA Outcomes Study. AA and non-AA groups were compared for maternal 25(OH)D by Mann–Whitney U-test. Compared to non-AA women, AA women were more likely to be vitamin D deficient (<50 nmol/L; 84 vs. 37%, p < 0.001), and more of their infants had at least one infection in the first 6 months (78.3% and 59.6% of infants, respectively, p = 0.022). We next explored the relationship between maternal plasma 25(OH)D concentration and infant infections using Spearman correlations. Maternal 25(OH)D concentration was inversely correlated with the number of all infections (p = 0.033), eye, ear, nose, and throat (EENT) infections (p = 0.043), and skin infection (p = 0.021) in the first 6 months. A model that included maternal education, income, and 25(OH)D identified maternal education as the only significant predictor of infection risk in the first 6 months (p = 0.045); however, maternal education, income, and 25(OH)D were all significantly lower in AA women compared to non-AA women . The high degree of correlation between these variables does not allow determination of which factor is driving the risk of infection; however, the one that is most easily remediated is vitamin D status. It would be of value to learn if vitamin D supplementation in this at-risk group could ameliorate at least part of the increased infection risk.
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spelling pubmed-58526872018-03-19 Maternal Vitamin D Status and Infant Infection Moukarzel, Sara Ozias, Marlies Kerling, Elizabeth Christifano, Danielle Wick, Jo Colombo, John Carlson, Susan Nutrients Article Maternal vitamin D status during pregnancy may modulate fetal immune system development and infant susceptibility to infections. Vitamin D deficiency is common during pregnancy, particularly among African American (AA) women. Our objective was to compare maternal vitamin D status (plasma 25(OH)D concentration) during pregnancy and first-year infections in the offspring of African American (AA) and non-AA women. We used medical records to record frequency and type of infections during the first year of life of 220 term infants (69 AA, 151 non-AA) whose mothers participated in the Kansas University DHA Outcomes Study. AA and non-AA groups were compared for maternal 25(OH)D by Mann–Whitney U-test. Compared to non-AA women, AA women were more likely to be vitamin D deficient (<50 nmol/L; 84 vs. 37%, p < 0.001), and more of their infants had at least one infection in the first 6 months (78.3% and 59.6% of infants, respectively, p = 0.022). We next explored the relationship between maternal plasma 25(OH)D concentration and infant infections using Spearman correlations. Maternal 25(OH)D concentration was inversely correlated with the number of all infections (p = 0.033), eye, ear, nose, and throat (EENT) infections (p = 0.043), and skin infection (p = 0.021) in the first 6 months. A model that included maternal education, income, and 25(OH)D identified maternal education as the only significant predictor of infection risk in the first 6 months (p = 0.045); however, maternal education, income, and 25(OH)D were all significantly lower in AA women compared to non-AA women . The high degree of correlation between these variables does not allow determination of which factor is driving the risk of infection; however, the one that is most easily remediated is vitamin D status. It would be of value to learn if vitamin D supplementation in this at-risk group could ameliorate at least part of the increased infection risk. MDPI 2018-01-23 /pmc/articles/PMC5852687/ /pubmed/29360733 http://dx.doi.org/10.3390/nu10020111 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Moukarzel, Sara
Ozias, Marlies
Kerling, Elizabeth
Christifano, Danielle
Wick, Jo
Colombo, John
Carlson, Susan
Maternal Vitamin D Status and Infant Infection
title Maternal Vitamin D Status and Infant Infection
title_full Maternal Vitamin D Status and Infant Infection
title_fullStr Maternal Vitamin D Status and Infant Infection
title_full_unstemmed Maternal Vitamin D Status and Infant Infection
title_short Maternal Vitamin D Status and Infant Infection
title_sort maternal vitamin d status and infant infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852687/
https://www.ncbi.nlm.nih.gov/pubmed/29360733
http://dx.doi.org/10.3390/nu10020111
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