Cargando…

Dietary Magnesium and Cardiovascular Disease: A Review with Emphasis in Epidemiological Studies

Magnesium (Mg) is an essential dietary element for humans involved in key biological processes. A growing body of evidence from epidemiological studies, randomized controlled trials (RCTs) and meta-analyses have indicated inverse associations between Mg intake and cardiovascular diseases (CVD). The...

Descripción completa

Detalles Bibliográficos
Autores principales: Rosique-Esteban, Nuria, Guasch-Ferré, Marta, Hernández-Alonso, Pablo, Salas-Salvadó, Jordi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852744/
https://www.ncbi.nlm.nih.gov/pubmed/29389872
http://dx.doi.org/10.3390/nu10020168
_version_ 1783306624838926336
author Rosique-Esteban, Nuria
Guasch-Ferré, Marta
Hernández-Alonso, Pablo
Salas-Salvadó, Jordi
author_facet Rosique-Esteban, Nuria
Guasch-Ferré, Marta
Hernández-Alonso, Pablo
Salas-Salvadó, Jordi
author_sort Rosique-Esteban, Nuria
collection PubMed
description Magnesium (Mg) is an essential dietary element for humans involved in key biological processes. A growing body of evidence from epidemiological studies, randomized controlled trials (RCTs) and meta-analyses have indicated inverse associations between Mg intake and cardiovascular diseases (CVD). The present review aims to summarize recent scientific evidence on the topic, with a focus on data from epidemiological studies assessing the associations between Mg intake and major cardiovascular (CV) risk factors and CVD. We also aimed to review current literature on circulating Mg and CVD, as well as potential biological processes underlying these observations. We concluded that high Mg intake is associated with lower risk of major CV risk factors (mainly metabolic syndrome, diabetes and hypertension), stroke and total CVD. Higher levels of circulating Mg are associated with lower risk of CVD, mainly ischemic heart disease and coronary heart disease. Further, RCTs and prospective studies would help to clarify whether Mg intake and Mg circulating levels may also protect against other CVDs and CVD death.
format Online
Article
Text
id pubmed-5852744
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-58527442018-03-19 Dietary Magnesium and Cardiovascular Disease: A Review with Emphasis in Epidemiological Studies Rosique-Esteban, Nuria Guasch-Ferré, Marta Hernández-Alonso, Pablo Salas-Salvadó, Jordi Nutrients Review Magnesium (Mg) is an essential dietary element for humans involved in key biological processes. A growing body of evidence from epidemiological studies, randomized controlled trials (RCTs) and meta-analyses have indicated inverse associations between Mg intake and cardiovascular diseases (CVD). The present review aims to summarize recent scientific evidence on the topic, with a focus on data from epidemiological studies assessing the associations between Mg intake and major cardiovascular (CV) risk factors and CVD. We also aimed to review current literature on circulating Mg and CVD, as well as potential biological processes underlying these observations. We concluded that high Mg intake is associated with lower risk of major CV risk factors (mainly metabolic syndrome, diabetes and hypertension), stroke and total CVD. Higher levels of circulating Mg are associated with lower risk of CVD, mainly ischemic heart disease and coronary heart disease. Further, RCTs and prospective studies would help to clarify whether Mg intake and Mg circulating levels may also protect against other CVDs and CVD death. MDPI 2018-02-01 /pmc/articles/PMC5852744/ /pubmed/29389872 http://dx.doi.org/10.3390/nu10020168 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rosique-Esteban, Nuria
Guasch-Ferré, Marta
Hernández-Alonso, Pablo
Salas-Salvadó, Jordi
Dietary Magnesium and Cardiovascular Disease: A Review with Emphasis in Epidemiological Studies
title Dietary Magnesium and Cardiovascular Disease: A Review with Emphasis in Epidemiological Studies
title_full Dietary Magnesium and Cardiovascular Disease: A Review with Emphasis in Epidemiological Studies
title_fullStr Dietary Magnesium and Cardiovascular Disease: A Review with Emphasis in Epidemiological Studies
title_full_unstemmed Dietary Magnesium and Cardiovascular Disease: A Review with Emphasis in Epidemiological Studies
title_short Dietary Magnesium and Cardiovascular Disease: A Review with Emphasis in Epidemiological Studies
title_sort dietary magnesium and cardiovascular disease: a review with emphasis in epidemiological studies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852744/
https://www.ncbi.nlm.nih.gov/pubmed/29389872
http://dx.doi.org/10.3390/nu10020168
work_keys_str_mv AT rosiqueestebannuria dietarymagnesiumandcardiovasculardiseaseareviewwithemphasisinepidemiologicalstudies
AT guaschferremarta dietarymagnesiumandcardiovasculardiseaseareviewwithemphasisinepidemiologicalstudies
AT hernandezalonsopablo dietarymagnesiumandcardiovasculardiseaseareviewwithemphasisinepidemiologicalstudies
AT salassalvadojordi dietarymagnesiumandcardiovasculardiseaseareviewwithemphasisinepidemiologicalstudies