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Dietary Magnesium and Cardiovascular Disease: A Review with Emphasis in Epidemiological Studies
Magnesium (Mg) is an essential dietary element for humans involved in key biological processes. A growing body of evidence from epidemiological studies, randomized controlled trials (RCTs) and meta-analyses have indicated inverse associations between Mg intake and cardiovascular diseases (CVD). The...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852744/ https://www.ncbi.nlm.nih.gov/pubmed/29389872 http://dx.doi.org/10.3390/nu10020168 |
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author | Rosique-Esteban, Nuria Guasch-Ferré, Marta Hernández-Alonso, Pablo Salas-Salvadó, Jordi |
author_facet | Rosique-Esteban, Nuria Guasch-Ferré, Marta Hernández-Alonso, Pablo Salas-Salvadó, Jordi |
author_sort | Rosique-Esteban, Nuria |
collection | PubMed |
description | Magnesium (Mg) is an essential dietary element for humans involved in key biological processes. A growing body of evidence from epidemiological studies, randomized controlled trials (RCTs) and meta-analyses have indicated inverse associations between Mg intake and cardiovascular diseases (CVD). The present review aims to summarize recent scientific evidence on the topic, with a focus on data from epidemiological studies assessing the associations between Mg intake and major cardiovascular (CV) risk factors and CVD. We also aimed to review current literature on circulating Mg and CVD, as well as potential biological processes underlying these observations. We concluded that high Mg intake is associated with lower risk of major CV risk factors (mainly metabolic syndrome, diabetes and hypertension), stroke and total CVD. Higher levels of circulating Mg are associated with lower risk of CVD, mainly ischemic heart disease and coronary heart disease. Further, RCTs and prospective studies would help to clarify whether Mg intake and Mg circulating levels may also protect against other CVDs and CVD death. |
format | Online Article Text |
id | pubmed-5852744 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-58527442018-03-19 Dietary Magnesium and Cardiovascular Disease: A Review with Emphasis in Epidemiological Studies Rosique-Esteban, Nuria Guasch-Ferré, Marta Hernández-Alonso, Pablo Salas-Salvadó, Jordi Nutrients Review Magnesium (Mg) is an essential dietary element for humans involved in key biological processes. A growing body of evidence from epidemiological studies, randomized controlled trials (RCTs) and meta-analyses have indicated inverse associations between Mg intake and cardiovascular diseases (CVD). The present review aims to summarize recent scientific evidence on the topic, with a focus on data from epidemiological studies assessing the associations between Mg intake and major cardiovascular (CV) risk factors and CVD. We also aimed to review current literature on circulating Mg and CVD, as well as potential biological processes underlying these observations. We concluded that high Mg intake is associated with lower risk of major CV risk factors (mainly metabolic syndrome, diabetes and hypertension), stroke and total CVD. Higher levels of circulating Mg are associated with lower risk of CVD, mainly ischemic heart disease and coronary heart disease. Further, RCTs and prospective studies would help to clarify whether Mg intake and Mg circulating levels may also protect against other CVDs and CVD death. MDPI 2018-02-01 /pmc/articles/PMC5852744/ /pubmed/29389872 http://dx.doi.org/10.3390/nu10020168 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rosique-Esteban, Nuria Guasch-Ferré, Marta Hernández-Alonso, Pablo Salas-Salvadó, Jordi Dietary Magnesium and Cardiovascular Disease: A Review with Emphasis in Epidemiological Studies |
title | Dietary Magnesium and Cardiovascular Disease: A Review with Emphasis in Epidemiological Studies |
title_full | Dietary Magnesium and Cardiovascular Disease: A Review with Emphasis in Epidemiological Studies |
title_fullStr | Dietary Magnesium and Cardiovascular Disease: A Review with Emphasis in Epidemiological Studies |
title_full_unstemmed | Dietary Magnesium and Cardiovascular Disease: A Review with Emphasis in Epidemiological Studies |
title_short | Dietary Magnesium and Cardiovascular Disease: A Review with Emphasis in Epidemiological Studies |
title_sort | dietary magnesium and cardiovascular disease: a review with emphasis in epidemiological studies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852744/ https://www.ncbi.nlm.nih.gov/pubmed/29389872 http://dx.doi.org/10.3390/nu10020168 |
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