Lower activation of caspase-1 by Staphylococcus epidermidis isolated from prosthetic joint infections compared to commensals

Nosocomial sequence types of Staphylococcus epidermidis dominate in prosthetic joint infections. We examined caspase-1 activation in human neutrophils after incubation with Staphylococcus epidermidis isolated from prosthetic joint infections and normal skin flora. Active caspase-1 was lower after in...

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Autores principales: Månsson, Emeli, Sahdo, Berolla, Nilsdotter-Augustinsson, Åsa, Särndahl, Eva, Söderquist, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852842/
https://www.ncbi.nlm.nih.gov/pubmed/29545990
http://dx.doi.org/10.7150/jbji.21567
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author Månsson, Emeli
Sahdo, Berolla
Nilsdotter-Augustinsson, Åsa
Särndahl, Eva
Söderquist, Bo
author_facet Månsson, Emeli
Sahdo, Berolla
Nilsdotter-Augustinsson, Åsa
Särndahl, Eva
Söderquist, Bo
author_sort Månsson, Emeli
collection PubMed
description Nosocomial sequence types of Staphylococcus epidermidis dominate in prosthetic joint infections. We examined caspase-1 activation in human neutrophils after incubation with Staphylococcus epidermidis isolated from prosthetic joint infections and normal skin flora. Active caspase-1 was lower after incubation with isolates from prosthetic joint infections than after incubation with commensal isolates. Both host and isolate dependent differences in active caspase-1 were noted. Our results indicate that there might be a host-dependent incapacity to elicit a strong caspase-1 response towards certain strains of S. epidermidis. Further experiments with a larger number of individuals are warranted.
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spelling pubmed-58528422018-03-15 Lower activation of caspase-1 by Staphylococcus epidermidis isolated from prosthetic joint infections compared to commensals Månsson, Emeli Sahdo, Berolla Nilsdotter-Augustinsson, Åsa Särndahl, Eva Söderquist, Bo J Bone Jt Infect Research Paper Nosocomial sequence types of Staphylococcus epidermidis dominate in prosthetic joint infections. We examined caspase-1 activation in human neutrophils after incubation with Staphylococcus epidermidis isolated from prosthetic joint infections and normal skin flora. Active caspase-1 was lower after incubation with isolates from prosthetic joint infections than after incubation with commensal isolates. Both host and isolate dependent differences in active caspase-1 were noted. Our results indicate that there might be a host-dependent incapacity to elicit a strong caspase-1 response towards certain strains of S. epidermidis. Further experiments with a larger number of individuals are warranted. Ivyspring International Publisher 2018-01-13 /pmc/articles/PMC5852842/ /pubmed/29545990 http://dx.doi.org/10.7150/jbji.21567 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Månsson, Emeli
Sahdo, Berolla
Nilsdotter-Augustinsson, Åsa
Särndahl, Eva
Söderquist, Bo
Lower activation of caspase-1 by Staphylococcus epidermidis isolated from prosthetic joint infections compared to commensals
title Lower activation of caspase-1 by Staphylococcus epidermidis isolated from prosthetic joint infections compared to commensals
title_full Lower activation of caspase-1 by Staphylococcus epidermidis isolated from prosthetic joint infections compared to commensals
title_fullStr Lower activation of caspase-1 by Staphylococcus epidermidis isolated from prosthetic joint infections compared to commensals
title_full_unstemmed Lower activation of caspase-1 by Staphylococcus epidermidis isolated from prosthetic joint infections compared to commensals
title_short Lower activation of caspase-1 by Staphylococcus epidermidis isolated from prosthetic joint infections compared to commensals
title_sort lower activation of caspase-1 by staphylococcus epidermidis isolated from prosthetic joint infections compared to commensals
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852842/
https://www.ncbi.nlm.nih.gov/pubmed/29545990
http://dx.doi.org/10.7150/jbji.21567
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