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The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women
Obesity-risk genes have been associated with dietary intake, appetite regulation, and gestational weight gain (GWG). The purpose of this study was to examine whether dietary intake including total energy intake and macronutrients modify or mediate the association between obesity-risk genes and GWG....
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852892/ https://www.ncbi.nlm.nih.gov/pubmed/29686896 http://dx.doi.org/10.1155/2018/5080492 |
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author | Meng, Ying Groth, Susan W. Li, Dongmei |
author_facet | Meng, Ying Groth, Susan W. Li, Dongmei |
author_sort | Meng, Ying |
collection | PubMed |
description | Obesity-risk genes have been associated with dietary intake, appetite regulation, and gestational weight gain (GWG). The purpose of this study was to examine whether dietary intake including total energy intake and macronutrients modify or mediate the association between obesity-risk genes and GWG. An observational study was conducted with 85 African American pregnant women. Sociodemographic, medical, and lifestyle factors and dietary recalls were collected during pregnancy. Seven obesity-risk genetic variants were genotyped. Regression analyses with bootstrapping methods were used to examine the moderation and mediation effects of dietary intake. The mean GWG was 14.2 kg, and 55.3% of the women gained above the Institute of Medicine GWG guidelines. A nominally significant association was found between rs17782313 (close to MC4R) and percentage of energy intake from fat (P=0.043). A variant downstream of KCTD15 (rs11084753) was nominally significantly related to GWG (P=0.023). There was a significant interaction between the KCTD15 polymorphism and dietary fat intake (P=0.048). Women with the AG genotype gained more weight during pregnancy with more dietary fat consumption. In conclusion, our results indicate that dietary macronutrients, especially fat intake, may modify the effect of the KCTD15 gene on GWG. Improved knowledge of gene-diet interactions can facilitate the development of personalized interventions. |
format | Online Article Text |
id | pubmed-5852892 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-58528922018-04-23 The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women Meng, Ying Groth, Susan W. Li, Dongmei J Nutr Metab Research Article Obesity-risk genes have been associated with dietary intake, appetite regulation, and gestational weight gain (GWG). The purpose of this study was to examine whether dietary intake including total energy intake and macronutrients modify or mediate the association between obesity-risk genes and GWG. An observational study was conducted with 85 African American pregnant women. Sociodemographic, medical, and lifestyle factors and dietary recalls were collected during pregnancy. Seven obesity-risk genetic variants were genotyped. Regression analyses with bootstrapping methods were used to examine the moderation and mediation effects of dietary intake. The mean GWG was 14.2 kg, and 55.3% of the women gained above the Institute of Medicine GWG guidelines. A nominally significant association was found between rs17782313 (close to MC4R) and percentage of energy intake from fat (P=0.043). A variant downstream of KCTD15 (rs11084753) was nominally significantly related to GWG (P=0.023). There was a significant interaction between the KCTD15 polymorphism and dietary fat intake (P=0.048). Women with the AG genotype gained more weight during pregnancy with more dietary fat consumption. In conclusion, our results indicate that dietary macronutrients, especially fat intake, may modify the effect of the KCTD15 gene on GWG. Improved knowledge of gene-diet interactions can facilitate the development of personalized interventions. Hindawi 2018-03-01 /pmc/articles/PMC5852892/ /pubmed/29686896 http://dx.doi.org/10.1155/2018/5080492 Text en Copyright © 2018 Ying Meng et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Meng, Ying Groth, Susan W. Li, Dongmei The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women |
title | The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women |
title_full | The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women |
title_fullStr | The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women |
title_full_unstemmed | The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women |
title_short | The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women |
title_sort | association between obesity-risk genes and gestational weight gain is modified by dietary intake in african american women |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852892/ https://www.ncbi.nlm.nih.gov/pubmed/29686896 http://dx.doi.org/10.1155/2018/5080492 |
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