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Humanized DRAGA mice immunized with Plasmodium falciparum sporozoites and chloroquine elicit protective pre-erythrocytic immunity

BACKGROUND: Human-immune-system humanized mouse models can bridge the gap between humans and conventional mice for testing human vaccines. The HLA-expressing humanized DRAGA (HLA-A2.HLA-DR4.Rag1KO.IL2RγcKO.NOD) mice reconstitute a functional human-immune-system and sustain the complete life cycle of...

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Detalles Bibliográficos
Autores principales:	Majji, Sai, Wijayalath, Wathsala, Shashikumar, Soumya, Brumeanu, Teodor D., Casares, Sofia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853061/ https://www.ncbi.nlm.nih.gov/pubmed/29540197 http://dx.doi.org/10.1186/s12936-018-2264-y

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