Comparison of single nucleotide polymorphisms in the 3′ untranslated region of HLA-G in placentas between spontaneous preterm birth and preeclampsia

OBJECTIVE: To compare single nucleotide polymorphisms (SNPs) in the 3′-untranslated region (3′UTR) of human leukocyte antigen (HLA)-G in placentas between spontaneous preterm birth and preeclampsia pregnancies. RESULTS: Placental samples matched for gestational age were obtained from 20 cases of spo...

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Autores principales: Lee, Ji Young, Kim, Hyun Mi, Kim, Mi Ju, Cha, Hyun-Hwa, Seong, Won Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853103/
https://www.ncbi.nlm.nih.gov/pubmed/29540242
http://dx.doi.org/10.1186/s13104-018-3280-2
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author Lee, Ji Young
Kim, Hyun Mi
Kim, Mi Ju
Cha, Hyun-Hwa
Seong, Won Joon
author_facet Lee, Ji Young
Kim, Hyun Mi
Kim, Mi Ju
Cha, Hyun-Hwa
Seong, Won Joon
author_sort Lee, Ji Young
collection PubMed
description OBJECTIVE: To compare single nucleotide polymorphisms (SNPs) in the 3′-untranslated region (3′UTR) of human leukocyte antigen (HLA)-G in placentas between spontaneous preterm birth and preeclampsia pregnancies. RESULTS: Placental samples matched for gestational age were obtained from 20 cases of spontaneous preterm births and 19 cases of preeclampsia. Genomic deoxyribonucleic acid was extracted from placenta tissue and the 3′UTR region of HLA-G was amplified via polymerase chain reaction. Nine SNPs were analyzed by direct Sanger sequencing. There was no significant difference in gestational age at delivery or birth weight between two groups. And there were no significant differences in the allele and phenotype frequencies between two groups.
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spelling pubmed-58531032018-03-22 Comparison of single nucleotide polymorphisms in the 3′ untranslated region of HLA-G in placentas between spontaneous preterm birth and preeclampsia Lee, Ji Young Kim, Hyun Mi Kim, Mi Ju Cha, Hyun-Hwa Seong, Won Joon BMC Res Notes Research Note OBJECTIVE: To compare single nucleotide polymorphisms (SNPs) in the 3′-untranslated region (3′UTR) of human leukocyte antigen (HLA)-G in placentas between spontaneous preterm birth and preeclampsia pregnancies. RESULTS: Placental samples matched for gestational age were obtained from 20 cases of spontaneous preterm births and 19 cases of preeclampsia. Genomic deoxyribonucleic acid was extracted from placenta tissue and the 3′UTR region of HLA-G was amplified via polymerase chain reaction. Nine SNPs were analyzed by direct Sanger sequencing. There was no significant difference in gestational age at delivery or birth weight between two groups. And there were no significant differences in the allele and phenotype frequencies between two groups. BioMed Central 2018-03-14 /pmc/articles/PMC5853103/ /pubmed/29540242 http://dx.doi.org/10.1186/s13104-018-3280-2 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Note
Lee, Ji Young
Kim, Hyun Mi
Kim, Mi Ju
Cha, Hyun-Hwa
Seong, Won Joon
Comparison of single nucleotide polymorphisms in the 3′ untranslated region of HLA-G in placentas between spontaneous preterm birth and preeclampsia
title Comparison of single nucleotide polymorphisms in the 3′ untranslated region of HLA-G in placentas between spontaneous preterm birth and preeclampsia
title_full Comparison of single nucleotide polymorphisms in the 3′ untranslated region of HLA-G in placentas between spontaneous preterm birth and preeclampsia
title_fullStr Comparison of single nucleotide polymorphisms in the 3′ untranslated region of HLA-G in placentas between spontaneous preterm birth and preeclampsia
title_full_unstemmed Comparison of single nucleotide polymorphisms in the 3′ untranslated region of HLA-G in placentas between spontaneous preterm birth and preeclampsia
title_short Comparison of single nucleotide polymorphisms in the 3′ untranslated region of HLA-G in placentas between spontaneous preterm birth and preeclampsia
title_sort comparison of single nucleotide polymorphisms in the 3′ untranslated region of hla-g in placentas between spontaneous preterm birth and preeclampsia
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853103/
https://www.ncbi.nlm.nih.gov/pubmed/29540242
http://dx.doi.org/10.1186/s13104-018-3280-2
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