Effects of HIV infection and ART on phenotype and function of circulating monocytes, natural killer, and innate lymphoid cells

HIV infection causes upregulation of markers of inflammation, immune activation and apoptosis of host adaptive, and innate immune cells particularly monocytes, natural killer (NK) and innate lymphoid cells (ILCs). Although antiretroviral therapy (ART) restores CD4 T-cell counts, the persistent aberr...

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Autores principales: Nabatanzi, Rose, Cose, Stephen, Joloba, Moses, Jones, Sarah Rowland, Nakanjako, Damalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853105/
https://www.ncbi.nlm.nih.gov/pubmed/29544508
http://dx.doi.org/10.1186/s12981-018-0194-y
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author Nabatanzi, Rose
Cose, Stephen
Joloba, Moses
Jones, Sarah Rowland
Nakanjako, Damalie
author_facet Nabatanzi, Rose
Cose, Stephen
Joloba, Moses
Jones, Sarah Rowland
Nakanjako, Damalie
author_sort Nabatanzi, Rose
collection PubMed
description HIV infection causes upregulation of markers of inflammation, immune activation and apoptosis of host adaptive, and innate immune cells particularly monocytes, natural killer (NK) and innate lymphoid cells (ILCs). Although antiretroviral therapy (ART) restores CD4 T-cell counts, the persistent aberrant activation of monocytes, NK and ILCs observed likely contributes to the incomplete recovery of T-cell effector functions. A better understanding of the effects of HIV infection and ART on the phenotype and function of circulating monocytes, NK, and ILCs is required to guide development of novel therapeutic interventions to optimize immune recovery.
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spelling pubmed-58531052018-03-22 Effects of HIV infection and ART on phenotype and function of circulating monocytes, natural killer, and innate lymphoid cells Nabatanzi, Rose Cose, Stephen Joloba, Moses Jones, Sarah Rowland Nakanjako, Damalie AIDS Res Ther Review HIV infection causes upregulation of markers of inflammation, immune activation and apoptosis of host adaptive, and innate immune cells particularly monocytes, natural killer (NK) and innate lymphoid cells (ILCs). Although antiretroviral therapy (ART) restores CD4 T-cell counts, the persistent aberrant activation of monocytes, NK and ILCs observed likely contributes to the incomplete recovery of T-cell effector functions. A better understanding of the effects of HIV infection and ART on the phenotype and function of circulating monocytes, NK, and ILCs is required to guide development of novel therapeutic interventions to optimize immune recovery. BioMed Central 2018-03-15 /pmc/articles/PMC5853105/ /pubmed/29544508 http://dx.doi.org/10.1186/s12981-018-0194-y Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Nabatanzi, Rose
Cose, Stephen
Joloba, Moses
Jones, Sarah Rowland
Nakanjako, Damalie
Effects of HIV infection and ART on phenotype and function of circulating monocytes, natural killer, and innate lymphoid cells
title Effects of HIV infection and ART on phenotype and function of circulating monocytes, natural killer, and innate lymphoid cells
title_full Effects of HIV infection and ART on phenotype and function of circulating monocytes, natural killer, and innate lymphoid cells
title_fullStr Effects of HIV infection and ART on phenotype and function of circulating monocytes, natural killer, and innate lymphoid cells
title_full_unstemmed Effects of HIV infection and ART on phenotype and function of circulating monocytes, natural killer, and innate lymphoid cells
title_short Effects of HIV infection and ART on phenotype and function of circulating monocytes, natural killer, and innate lymphoid cells
title_sort effects of hiv infection and art on phenotype and function of circulating monocytes, natural killer, and innate lymphoid cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853105/
https://www.ncbi.nlm.nih.gov/pubmed/29544508
http://dx.doi.org/10.1186/s12981-018-0194-y
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