Metabotropic Glutamate Receptor 1 acts as a Dependence Receptor Creating a Requirement for Glutamate to Sustain the Viability and Growth of Human Melanomas

Metabotropic glutamate 1 (mGlu) receptor has been proposed as a target for the treatment of metastatic melanoma. Studies have demonstrated that inhibiting the release of glutamate (the natural ligand of mGlu1 receptors), results in a decrease of melanoma tumor growth in mGlu1 receptor-expressing mel...

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Detalles Bibliográficos
Autores principales: Gelb, Tara, Pshenichkin, Sergey, Rodriguez, Olga C., Hathaway, Hannah A., Grajkowska, Ewa, DiRaddo, John O., Wroblewska, Barbara, Yasuda, Robert, Albanese, Chris, Wolfe, Barry B., Wroblewski, Jarda T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853109/
https://www.ncbi.nlm.nih.gov/pubmed/25065592
http://dx.doi.org/10.1038/onc.2014.231

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