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The role of surgical treatment in isolated organ recurrence of esophageal cancer—a systematic review of the literature

BACKGROUND: Despite the improvements in the early detection and treatment of non-metastatic esophageal cancer, more than half of patients undergoing a curative treatment for esophageal cancer will develop recurrence within three years. The prognosis of these patients is poor. However, a wide range i...

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Autores principales: Schizas, Dimitrios, Lazaridis, Ioannis I., Moris, Demetrios, Mastoraki, Aikaterini, Lazaridis, Lazaros-Dimitrios, Tsilimigras, Diamantis I., Charalampakis, Nikolaos, Liakakos, Theodore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853115/
https://www.ncbi.nlm.nih.gov/pubmed/29540179
http://dx.doi.org/10.1186/s12957-018-1357-y
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author Schizas, Dimitrios
Lazaridis, Ioannis I.
Moris, Demetrios
Mastoraki, Aikaterini
Lazaridis, Lazaros-Dimitrios
Tsilimigras, Diamantis I.
Charalampakis, Nikolaos
Liakakos, Theodore
author_facet Schizas, Dimitrios
Lazaridis, Ioannis I.
Moris, Demetrios
Mastoraki, Aikaterini
Lazaridis, Lazaros-Dimitrios
Tsilimigras, Diamantis I.
Charalampakis, Nikolaos
Liakakos, Theodore
author_sort Schizas, Dimitrios
collection PubMed
description BACKGROUND: Despite the improvements in the early detection and treatment of non-metastatic esophageal cancer, more than half of patients undergoing a curative treatment for esophageal cancer will develop recurrence within three years. The prognosis of these patients is poor. However, a wide range in overall survival has been reported, depending on the pattern of recurrence, and no optimal treatment strategy following recurrence has yet been uniformly accepted. AIM: In this article, we aimed to systematically review the literature for the role of surgical resection of metachronous distant metastasis following primary treatment of esophageal cancer. Furthermore, we discuss possible factors that could possibly predict which patients may benefit from a surgical approach. A comprehensive literature search was conducted in PubMed using combinations of keywords. RESULTS: Patients with recurrence may benefit of a multimodality treatment. Regarding the isolated recurrence of esophageal cancer in solid visceral organs, operative intervention has been proposed as a treatment that may offer a survival benefit in an individual basis. No definitive conclusions regarding the potential survival advantage offered by the surgical treatment of solitary recurrent lesions can be drawn. However, recent improvements in surgical treatment and optimization of perioperative management guarantee an acceptable operative risk, making surgical resection of solitary recurrence lesions a considerable therapeutic option. CONCLUSIONS: It can be conferred from the available studies that the surgical treatment of isolated recurrence from esophageal cancer may offer a survival benefit for properly selected patients. Prospective, multicenter studies might be useful to gain a better insight into those factors that affect selection of patients to take benefit from an operative intervention.
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spelling pubmed-58531152018-03-22 The role of surgical treatment in isolated organ recurrence of esophageal cancer—a systematic review of the literature Schizas, Dimitrios Lazaridis, Ioannis I. Moris, Demetrios Mastoraki, Aikaterini Lazaridis, Lazaros-Dimitrios Tsilimigras, Diamantis I. Charalampakis, Nikolaos Liakakos, Theodore World J Surg Oncol Review BACKGROUND: Despite the improvements in the early detection and treatment of non-metastatic esophageal cancer, more than half of patients undergoing a curative treatment for esophageal cancer will develop recurrence within three years. The prognosis of these patients is poor. However, a wide range in overall survival has been reported, depending on the pattern of recurrence, and no optimal treatment strategy following recurrence has yet been uniformly accepted. AIM: In this article, we aimed to systematically review the literature for the role of surgical resection of metachronous distant metastasis following primary treatment of esophageal cancer. Furthermore, we discuss possible factors that could possibly predict which patients may benefit from a surgical approach. A comprehensive literature search was conducted in PubMed using combinations of keywords. RESULTS: Patients with recurrence may benefit of a multimodality treatment. Regarding the isolated recurrence of esophageal cancer in solid visceral organs, operative intervention has been proposed as a treatment that may offer a survival benefit in an individual basis. No definitive conclusions regarding the potential survival advantage offered by the surgical treatment of solitary recurrent lesions can be drawn. However, recent improvements in surgical treatment and optimization of perioperative management guarantee an acceptable operative risk, making surgical resection of solitary recurrence lesions a considerable therapeutic option. CONCLUSIONS: It can be conferred from the available studies that the surgical treatment of isolated recurrence from esophageal cancer may offer a survival benefit for properly selected patients. Prospective, multicenter studies might be useful to gain a better insight into those factors that affect selection of patients to take benefit from an operative intervention. BioMed Central 2018-03-14 /pmc/articles/PMC5853115/ /pubmed/29540179 http://dx.doi.org/10.1186/s12957-018-1357-y Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Schizas, Dimitrios
Lazaridis, Ioannis I.
Moris, Demetrios
Mastoraki, Aikaterini
Lazaridis, Lazaros-Dimitrios
Tsilimigras, Diamantis I.
Charalampakis, Nikolaos
Liakakos, Theodore
The role of surgical treatment in isolated organ recurrence of esophageal cancer—a systematic review of the literature
title The role of surgical treatment in isolated organ recurrence of esophageal cancer—a systematic review of the literature
title_full The role of surgical treatment in isolated organ recurrence of esophageal cancer—a systematic review of the literature
title_fullStr The role of surgical treatment in isolated organ recurrence of esophageal cancer—a systematic review of the literature
title_full_unstemmed The role of surgical treatment in isolated organ recurrence of esophageal cancer—a systematic review of the literature
title_short The role of surgical treatment in isolated organ recurrence of esophageal cancer—a systematic review of the literature
title_sort role of surgical treatment in isolated organ recurrence of esophageal cancer—a systematic review of the literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853115/
https://www.ncbi.nlm.nih.gov/pubmed/29540179
http://dx.doi.org/10.1186/s12957-018-1357-y
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