Asian G6PD-Mahidol Reticulocytes Sustain Normal Plasmodium Vivax Development

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymatic disorder in humans and appears to be protective against falciparum severe malaria. Controversially, it is also thought that Plasmodium vivax has driven the recent selection of G6PD alleles. We use an experimental approa...

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Autores principales: Bancone, Germana, Malleret, Benoit, Suwanarusk, Rossarin, Chowwiwat, Nongnud, Chu, Cindy S, McGready, Rose, Rénia, Laurent, Nosten, François, Russell, Bruce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853331/
https://www.ncbi.nlm.nih.gov/pubmed/28591790
http://dx.doi.org/10.1093/infdis/jix278
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author Bancone, Germana
Malleret, Benoit
Suwanarusk, Rossarin
Chowwiwat, Nongnud
Chu, Cindy S
McGready, Rose
Rénia, Laurent
Nosten, François
Russell, Bruce
author_facet Bancone, Germana
Malleret, Benoit
Suwanarusk, Rossarin
Chowwiwat, Nongnud
Chu, Cindy S
McGready, Rose
Rénia, Laurent
Nosten, François
Russell, Bruce
author_sort Bancone, Germana
collection PubMed
description Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymatic disorder in humans and appears to be protective against falciparum severe malaria. Controversially, it is also thought that Plasmodium vivax has driven the recent selection of G6PD alleles. We use an experimental approach to determine whether G6PD-Mahidol(G487A) variant, a widespread cause of severe G6PD deficiency in Southeast Asia, provides a barrier against vivax malaria. Our results show that the immature reticulocytes (CD71(+)) targeted by P. vivax invasion are enzymatically normal, even in hemizygous G6PD-Mahidol (G487A) mutants; thus, allowing the normal growth, development, and high parasite density in severely deficient samples.
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spelling pubmed-58533312018-03-23 Asian G6PD-Mahidol Reticulocytes Sustain Normal Plasmodium Vivax Development Bancone, Germana Malleret, Benoit Suwanarusk, Rossarin Chowwiwat, Nongnud Chu, Cindy S McGready, Rose Rénia, Laurent Nosten, François Russell, Bruce J Infect Dis Brief Reports Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymatic disorder in humans and appears to be protective against falciparum severe malaria. Controversially, it is also thought that Plasmodium vivax has driven the recent selection of G6PD alleles. We use an experimental approach to determine whether G6PD-Mahidol(G487A) variant, a widespread cause of severe G6PD deficiency in Southeast Asia, provides a barrier against vivax malaria. Our results show that the immature reticulocytes (CD71(+)) targeted by P. vivax invasion are enzymatically normal, even in hemizygous G6PD-Mahidol (G487A) mutants; thus, allowing the normal growth, development, and high parasite density in severely deficient samples. Oxford University Press 2017-07-15 2017-06-07 /pmc/articles/PMC5853331/ /pubmed/28591790 http://dx.doi.org/10.1093/infdis/jix278 Text en © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Reports
Bancone, Germana
Malleret, Benoit
Suwanarusk, Rossarin
Chowwiwat, Nongnud
Chu, Cindy S
McGready, Rose
Rénia, Laurent
Nosten, François
Russell, Bruce
Asian G6PD-Mahidol Reticulocytes Sustain Normal Plasmodium Vivax Development
title Asian G6PD-Mahidol Reticulocytes Sustain Normal Plasmodium Vivax Development
title_full Asian G6PD-Mahidol Reticulocytes Sustain Normal Plasmodium Vivax Development
title_fullStr Asian G6PD-Mahidol Reticulocytes Sustain Normal Plasmodium Vivax Development
title_full_unstemmed Asian G6PD-Mahidol Reticulocytes Sustain Normal Plasmodium Vivax Development
title_short Asian G6PD-Mahidol Reticulocytes Sustain Normal Plasmodium Vivax Development
title_sort asian g6pd-mahidol reticulocytes sustain normal plasmodium vivax development
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853331/
https://www.ncbi.nlm.nih.gov/pubmed/28591790
http://dx.doi.org/10.1093/infdis/jix278
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