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Co-expression of a cyclizing asparaginyl endopeptidase enables efficient production of cyclic peptides in planta
Cyclotides are ultra-stable, backbone-cyclized plant defence peptides that have attracted considerable interest in the pharmaceutical industry. This is due to their range of native bioactivities as well as their ability to stabilize other bioactive peptides within their framework. However, a hindran...
Autores principales: | Poon, Simon, Harris, Karen S, Jackson, Mark A, McCorkelle, Owen C, Gilding, Edward K, Durek, Thomas, van der Weerden, Nicole L, Craik, David J, Anderson, Marilyn A |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853369/ https://www.ncbi.nlm.nih.gov/pubmed/29309615 http://dx.doi.org/10.1093/jxb/erx422 |
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