Cargando…

Association of Dynamic Changes in the CD4 T-Cell Transcriptome With Disease Severity During Primary Respiratory Syncytial Virus Infection in Young Infants

BACKGROUND: Nearly all children are infected with respiratory syncytial virus (RSV) within the first 2 years of life, with a minority developing severe disease (1%–3% hospitalized). We hypothesized that an assessment of the adaptive immune system, using CD4(+) T-lymphocyte transcriptomics, would ide...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mariani, Thomas J, Qiu, Xing, Chu, ChinYi, Wang, Lu, Thakar, Juilee, Holden-Wiltse, Jeanne, Corbett, Anthony, Topham, David J, Falsey, Ann R, Caserta, Mary T, Walsh, Edward E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Major Articles and Brief Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853440/ https://www.ncbi.nlm.nih.gov/pubmed/28962005 http://dx.doi.org/10.1093/infdis/jix400

Ejemplares similares

Aims, Study Design, and Enrollment Results From the Assessing Predictors of Infant Respiratory Syncytial Virus Effects and Severity Study
por: Walsh, Edward E, et al.
Publicado: (2019)

415. Airway Gene-Expression Classifiers for Respiratory Syncytial Virus (RSV) Disease Severity in Infants
por: Caserta, Mary T, et al.
Publicado: (2019)

Airway gene-expression classifiers for respiratory syncytial virus (RSV) disease severity in infants
por: Wang, Lu, et al.
Publicado: (2021)

Microbiome-Transcriptome Interactions Related to Severity of Respiratory Syncytial Virus Infection
por: Sonawane, Abhijeet R., et al.
Publicado: (2019)

The Healthy Infant Nasal Transcriptome: A Benchmark Study
por: Chu, Chin-Yi, et al.
Publicado: (2016)

A systems genomics approach uncovers molecular associates of RSV severity
por: McCall, Matthew N., et al.
Publicado: (2021)

Unbiased analysis of peripheral blood mononuclear cells reveals CD4 T cell response to RSV matrix protein
por: Thakar, Juilee, et al.
Publicado: (2020)

Measuring the Severity of Respiratory Illness in the First 2 Years of Life in Preterm and Term Infants
por: Caserta, Mary T., et al.
Publicado: (2019)

1409. Genomic Variation Among Respiratory Syncytial Viruses
por: Anderson, Christopher S, et al.
Publicado: (2020)

Transcriptomic Biomarkers to Discriminate Bacterial from Nonbacterial Infection in Adults Hospitalized with Respiratory Illness
por: Bhattacharya, Soumyaroop, et al.
Publicado: (2017)

Respiratory Syncytial Virus in Hematopoietic Cell Transplant Recipients: Factors Determining Progression to Lower Respiratory Tract Disease
por: Kim, Yae-Jean, et al.
Publicado: (2014)

Viral Respiratory Infections in Preterm Infants during and after Hospitalization
por: Caserta, Mary T., et al.
Publicado: (2017)

An Adjuvanted, Postfusion F Protein–Based Vaccine Did Not Prevent Respiratory Syncytial Virus Illness in Older Adults
por: Falloon, Judith, et al.
Publicado: (2017)

A Randomized Phase 1/2 Study of a Respiratory Syncytial Virus Prefusion F Vaccine
por: Walsh, Edward E, et al.
Publicado: (2021)

FUNNEL-GSEA: FUNctioNal ELastic-net regression in time-course gene set enrichment analysis
por: Zhang, Yun, et al.
Publicado: (2017)

Gene Expression Risk Scores for COVID-19 Illness Severity
por: Peterson, Derick R, et al.
Publicado: (2021)

The Source of Respiratory Syncytial Virus Infection In Infants: A Household Cohort Study In Rural Kenya
por: Munywoki, Patrick K., et al.
Publicado: (2014)

Phase 1/2 Randomized Study of the Immunogenicity, Safety, and Tolerability of a Respiratory Syncytial Virus Prefusion F Vaccine in Adults With Concomitant Inactivated Influenza Vaccine
por: Falsey, Ann R, et al.
Publicado: (2021)

Viral Load Dynamics and Clinical Disease Severity in Infants With Respiratory Syncytial Virus Infection
por: Garcia-Mauriño, Cristina, et al.
Publicado: (2019)

Respiratory Syncytial Virus and Other Respiratory Viral Infections in Older Adults With Moderate to Severe Influenza-like Illness
por: Falsey, Ann R., et al.
Publicado: (2014)

Eight practices for data management to enable team data science
por: McDavid, Andrew, et al.
Publicado: (2020)

Group- and Genotype-Specific Neutralizing Antibody Responses Against Respiratory Syncytial Virus in Infants and Young Children With Severe Pneumonia
por: Sande, Charles J., et al.
Publicado: (2013)

Respiratory Syncytial Virus Binds and Undergoes Transcription in Neutrophils From the Blood and Airways of Infants With Severe Bronchiolitis
por: Halfhide, Clare P., et al.
Publicado: (2011)

Risk Factors and Medical Resource Utilization of Respiratory Syncytial Virus, Human Metapneumovirus, and Influenza-Related Hospitalizations in Adults—A Global Study During the 2017–2019 Epidemic Seasons (Hospitalized Acute Respiratory Tract Infection [HARTI] Study)
por: Falsey, Ann R, et al.
Publicado: (2021)

Respiratory Syncytial Virus (RSV)–Specific Antibodies in Pregnant Women and Subsequent Risk of RSV Hospitalization in Young Infants
por: Koivisto, Karoliina, et al.
Publicado: (2021)

Respiratory Syncytial Virus–Associated Hospitalization Rates among US Infants: A Systematic Review and Meta-Analysis
por: McLaughlin, John M, et al.
Publicado: (2020)

Clinical Impact of Human Coronaviruses 229E and OC43 Infection in Diverse Adult Populations
por: Walsh, Edward E., et al.
Publicado: (2013)

Preparation of noninfectious scRNAseq samples from SARS-CoV-2-infected epithelial cells
por: Osborn, Raven M., et al.
Publicado: (2023)

Respiratory Syncytial Virus and All-Cause Bronchiolitis Hospitalizations Among Preterm Infants Using the Pediatric Health Information System (PHIS)
por: Fergie, Jaime, et al.
Publicado: (2020)

The Impact of Maternal Human Immunodeficiency Virus Infection on the Burden of Respiratory Syncytial Virus Among Pregnant Women and Their Infants, Western Kenya
por: Nyawanda, Bryan O, et al.
Publicado: (2020)

Viral Genetic Determinants of Prolonged Respiratory Syncytial Virus Infection Among Infants in a Healthy Term Birth Cohort
por: Lawless, Dylan, et al.
Publicado: (2022)

Antibody Responses to Respiratory Syncytial Virus: A Cross-Sectional Serosurveillance Study in the Dutch Population Focusing on Infants Younger Than 2 Years
por: Berbers, Guy, et al.
Publicado: (2020)

Recurrent Respiratory Syncytial Virus Infection in a CD14-Deficient Patient
por: Besteman, Sjanna B, et al.
Publicado: (2022)

Pneumococcal Conjugate Vaccines Are Protective Against Respiratory Syncytial Virus Hospitalizations in Infants: A Population-Based Observational Study
por: Le, Huong, et al.
Publicado: (2023)

Superiority of Transcriptional Profiling Over Procalcitonin for Distinguishing Bacterial From Viral Lower Respiratory Tract Infections in Hospitalized Adults
por: Suarez, Nicolas M., et al.
Publicado: (2015)

Respiratory Syncytial Virus Infection in Elderly Adults
por: Falsey, Ann R., et al.
Publicado: (2012)

Boolean Modeling of Cellular and Molecular Pathways Involved in Influenza Infection
por: Anderson, Christopher S., et al.
Publicado: (2016)

Novel Sequence-Based Mapping of Recently Emerging H5NX Influenza Viruses Reveals Pandemic Vaccine Candidates
por: Anderson, Christopher S., et al.
Publicado: (2016)

Insurance Status and the Risk of Severe Respiratory Syncytial Virus Disease in United States Preterm Infants Born at 32–35 Weeks Gestational Age
por: Franklin, Jeremy A., et al.
Publicado: (2016)

Neonatal gut and respiratory microbiota: coordinated development through time and space
por: Grier, Alex, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_jm82p24o2su7h2hgu8p3mvvvnp