Cargando…

A Critical Analysis of the Scientific and Commercial Rationales for the De Novo Synthesis of Horsepox Virus

This article evaluates the scientific and commercial rationales for the synthesis of horsepox virus. I find that the claimed benefits of using horsepox virus as a smallpox vaccine rest on a weak scientific foundation and an even weaker business case that this project will lead to a licensed medical...

Descripción completa

Detalles Bibliográficos
Autor principal:	Koblentz, Gregory D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Commentary
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853483/ https://www.ncbi.nlm.nih.gov/pubmed/29569633 http://dx.doi.org/10.1128/mSphere.00040-18

Ejemplares similares

A Holistic Assessment of the Risks and Benefits of the Synthesis of Horsepox Virus
por: DiEuliis, Diane, et al.
Publicado: (2018)

Re-creation of Horsepox Virus
por: Imperiale, Michael J.
Publicado: (2018)

Re-assembly of nineteenth-century smallpox vaccine genomes reveals the contemporaneous use of horsepox and horsepox-related viruses in the USA
por: Brinkmann, Annika, et al.
Publicado: (2020)

Erratum for DiEuliis and Gronvall, “A Holistic Assessment of the Risks and Benefits of the Synthesis of Horsepox Virus”
por: DiEuliis, Diane, et al.
Publicado: (2018)

Synthetic horsepox viruses and the continuing debate about dual use research
por: Noyce, Ryan S., et al.
Publicado: (2018)

Response to Brinkmann et al. “Re-assembly of 19th century smallpox vaccine genomes reveals the contemporaneous use of horsepox and horsepox-related viruses in the United States”
por: Duggan, Ana T., et al.
Publicado: (2020)

Construction of an infectious horsepox virus vaccine from chemically synthesized DNA fragments
por: Noyce, Ryan S., et al.
Publicado: (2018)

Horsepox: Framing a dual use research of concern debate
por: Coyne, Carolyn B.
Publicado: (2018)

Single Dose of Recombinant Chimeric Horsepox Virus (TNX-801) Vaccination Protects Macaques from Lethal Monkeypox Challenge
por: Noyce, Ryan S., et al.
Publicado: (2023)

Inhaled prostacyclin analogues in COVID-19 associated acute respiratory distress syndrome: scientific rationale
por: Mulia, Eka Prasetya Budi, et al.
Publicado: (2021)

Clinical translation of mesenchymal stromal cell extracellular vesicles: Considerations on scientific rationale and production requisites
por: Courageux, Yvan, et al.
Publicado: (2021)

Horsepox and the need for a new norm, more transparency, and stronger oversight for experiments that pose pandemic risks
por: Inglesby, Tom
Publicado: (2018)

Gene duplication, gene loss, and recombination events with variola virus shaped the complex evolutionary path of historical American horsepox-based smallpox vaccines
por: Souza, Aline R. V., et al.
Publicado: (2023)

De novo EUS-guided biliary drainage
por: Hara, Kazuo, et al.
Publicado: (2019)

Time to stop the use of ‘Wuhan virus’, ‘China virus’ or ‘Chinese virus’ across the scientific community
por: Su, Zhaohui, et al.
Publicado: (2020)

The NSABB Recommendations: Rationale, Impact, and Implications
por: Keim, Paul S.
Publicado: (2012)

Dual-Use Research as a Wicked Problem
por: Koblentz, Gregory D.
Publicado: (2014)

De novo telomere addition at chromosome breaks: Dangerous Liaisons
por: Churikov, Dmitri, et al.
Publicado: (2017)

Balancing commercial and public interests
por: Furberg, Curt D, et al.
Publicado: (2004)

Smart Bioinks as de novo Building Blocks to Bioengineer Living Tissues
por: Blaeser, Andreas, et al.
Publicado: (2019)

Challenging the rationale of routine vasopressor therapy for management of hypotension
por: Weil, Max Harry, et al.
Publicado: (2009)

Rationale for cannabis-based interventions in the opioid overdose crisis
por: Lucas, Philippe
Publicado: (2017)

A proposal for the reference-based annotation of de novo transposable element insertions
por: Bergman, Casey M.
Publicado: (2012)

De novo phasing with optimized XFEL data
por: Hao, Quan
Publicado: (2016)

Percutaneous dilatation tracheostomy: which technique is the best for the critically ill patient, and how can we gather further scientific evidence?
por: Brambrink, Ansgar
Publicado: (2004)

Commercial applications of quantum computing
por: Bova, Francesco, et al.
Publicado: (2021)

Open to the public: paywalls and the public rationale for open access medical research publishing
por: Day, Suzanne, et al.
Publicado: (2020)

Rationale for Further Medical and Health Research on High-Potency Sweeteners
por: Schiffman, Susan S.
Publicado: (2012)

Safety vs. efficacy assessment of pharmaceuticals: Epistemological rationales and methods
por: Osimani, Barbara
Publicado: (2014)

Present and future of health inequalities: Rationale for investing in the biological capital
por: Vaccarella, Salvatore, et al.
Publicado: (2020)

Nigeria's scientific contributions to COVID-19: A bibliometric analysis
por: Adebisi, Yusuff Adebayo, et al.
Publicado: (2022)

Using Scientific Articles on COVID-19 to Introduce the Nature of Scientific Knowledge to Medical Students
por: Ampatzidis, Georgios, et al.
Publicado: (2023)

Scientific rationale for a higher dose of nusinersen
por: Finkel, Richard S., et al.
Publicado: (2022)

Critical Appraisal of the Concept Frailty: Rating of Frailty in Elderly People has Weak Scientific Basis and should not be Used for Managing Individual Patients
por: Akner, Gunnar
Publicado: (2023)

Preexisting vs. de novo antibodies against SARS-CoV-2 in individuals without or with virus infection: impact on antibody therapy, vaccine research and serological testing
por: Muthumani, Kar, et al.
Publicado: (2021)

Rationale and recommendations for improving definitions, registration requirements and procedures related to fetal death and stillbirth
por: Joseph, KS, et al.
Publicado: (2016)

Getting rigorous with scientific rigor
por: Hofseth, Lorne J
Publicado: (2018)

Chemical datuments as scientific enablers
por: Rzepa, Henry S
Publicado: (2013)

The Scientific Conversation, Well Written
por: Wells, Rebecca G.
Publicado: (2016)

Use of Train of Four as a Guide to Neurological Recovery: What is the Rationale?
por: Kalita, N., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_9av4a6fgjrfi9f26a2ceoim00t