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Altered functional connectivity in blepharospasm/orofacial dystonia

INTRODUCTION: Blepharospasm is characterized by involuntary eyelid spasms. It can be associated with perioral dystonia (Meige's syndrome or orofacial dystonia). We aimed at studying resting‐state functional brain connectivity in these patients and its potential modulation by therapeutic botulin...

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Autores principales: Jochim, Angela, Li, Yong, Gora‐Stahlberg, Gina, Mantel, Tobias, Berndt, Maria, Castrop, Florian, Dresel, Christian, Haslinger, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853618/
https://www.ncbi.nlm.nih.gov/pubmed/29568690
http://dx.doi.org/10.1002/brb3.894
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author Jochim, Angela
Li, Yong
Gora‐Stahlberg, Gina
Mantel, Tobias
Berndt, Maria
Castrop, Florian
Dresel, Christian
Haslinger, Bernhard
author_facet Jochim, Angela
Li, Yong
Gora‐Stahlberg, Gina
Mantel, Tobias
Berndt, Maria
Castrop, Florian
Dresel, Christian
Haslinger, Bernhard
author_sort Jochim, Angela
collection PubMed
description INTRODUCTION: Blepharospasm is characterized by involuntary eyelid spasms. It can be associated with perioral dystonia (Meige's syndrome or orofacial dystonia). We aimed at studying resting‐state functional brain connectivity in these patients and its potential modulation by therapeutic botulinum toxin injections. METHODS: We performed resting‐state functional MRI and a region of interest‐based analysis of functional connectivity in 13 patients with blepharospasm/Meige's syndrome in comparison to 13 healthy controls. Patients were studied before and 4 weeks after botulinum toxin treatment. Simultaneous facial electromyography was applied to control for involuntary facial movements. RESULTS: Before botulinum toxin treatment, patients showed reduced functional connectivity between caudate and primary sensorimotor, somatosensory association and visual cortices as well as between putamen and parietal association cortex. Cerebellar areas displayed decreased functional connectivity to somatosensory and visual association cortices. On the cortical level, connectivity was reduced between the cingulate cortex and the primary sensorimotor/premotor and parietal association cortex, between premotor areas and the primary somatosensory cortices, and between the postcentral gyrus and temporoparietal, secondary somatosensory, cingular, and cerebellar regions. Botulinum toxin treatment modulated functional connectivity, especially between cerebellum and visual cortices. CONCLUSIONS: Patients with blepharospasm/Meige's syndrome show altered functional connectivity at rest in widespread brain regions including basal ganglia, cerebellar, primary/secondary sensorimotor, and visual areas. Functionally, this may reflect a predisposition for defective movement inhibition and sensorimotor integration. Botulinum toxin treatment could modulate brain connectivity in blepharospasm by altering visual and sensory input.
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spelling pubmed-58536182018-03-22 Altered functional connectivity in blepharospasm/orofacial dystonia Jochim, Angela Li, Yong Gora‐Stahlberg, Gina Mantel, Tobias Berndt, Maria Castrop, Florian Dresel, Christian Haslinger, Bernhard Brain Behav Original Research INTRODUCTION: Blepharospasm is characterized by involuntary eyelid spasms. It can be associated with perioral dystonia (Meige's syndrome or orofacial dystonia). We aimed at studying resting‐state functional brain connectivity in these patients and its potential modulation by therapeutic botulinum toxin injections. METHODS: We performed resting‐state functional MRI and a region of interest‐based analysis of functional connectivity in 13 patients with blepharospasm/Meige's syndrome in comparison to 13 healthy controls. Patients were studied before and 4 weeks after botulinum toxin treatment. Simultaneous facial electromyography was applied to control for involuntary facial movements. RESULTS: Before botulinum toxin treatment, patients showed reduced functional connectivity between caudate and primary sensorimotor, somatosensory association and visual cortices as well as between putamen and parietal association cortex. Cerebellar areas displayed decreased functional connectivity to somatosensory and visual association cortices. On the cortical level, connectivity was reduced between the cingulate cortex and the primary sensorimotor/premotor and parietal association cortex, between premotor areas and the primary somatosensory cortices, and between the postcentral gyrus and temporoparietal, secondary somatosensory, cingular, and cerebellar regions. Botulinum toxin treatment modulated functional connectivity, especially between cerebellum and visual cortices. CONCLUSIONS: Patients with blepharospasm/Meige's syndrome show altered functional connectivity at rest in widespread brain regions including basal ganglia, cerebellar, primary/secondary sensorimotor, and visual areas. Functionally, this may reflect a predisposition for defective movement inhibition and sensorimotor integration. Botulinum toxin treatment could modulate brain connectivity in blepharospasm by altering visual and sensory input. John Wiley and Sons Inc. 2017-12-18 /pmc/articles/PMC5853618/ /pubmed/29568690 http://dx.doi.org/10.1002/brb3.894 Text en © 2017 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Jochim, Angela
Li, Yong
Gora‐Stahlberg, Gina
Mantel, Tobias
Berndt, Maria
Castrop, Florian
Dresel, Christian
Haslinger, Bernhard
Altered functional connectivity in blepharospasm/orofacial dystonia
title Altered functional connectivity in blepharospasm/orofacial dystonia
title_full Altered functional connectivity in blepharospasm/orofacial dystonia
title_fullStr Altered functional connectivity in blepharospasm/orofacial dystonia
title_full_unstemmed Altered functional connectivity in blepharospasm/orofacial dystonia
title_short Altered functional connectivity in blepharospasm/orofacial dystonia
title_sort altered functional connectivity in blepharospasm/orofacial dystonia
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853618/
https://www.ncbi.nlm.nih.gov/pubmed/29568690
http://dx.doi.org/10.1002/brb3.894
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