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Polymeric Micelle of A(3)B-Type Lactosome as a Vehicle for Targeting Meningeal Dissemination
Polymeric micelle of the A(3)B-type lactosome comprising (poly(sarcosine))(3)-b-poly(l-lactic acid) was labeled with (111)In. The (111)In-labeled A(3)B-type lactosome was administered to the model mice bearing meningeal dissemination and bone metastasis at mandible. With single-photon emission compu...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853711/ https://www.ncbi.nlm.nih.gov/pubmed/29385027 http://dx.doi.org/10.3390/nano8020079 |
Sumario: | Polymeric micelle of the A(3)B-type lactosome comprising (poly(sarcosine))(3)-b-poly(l-lactic acid) was labeled with (111)In. The (111)In-labeled A(3)B-type lactosome was administered to the model mice bearing meningeal dissemination and bone metastasis at mandible. With single-photon emission computed tomography (SPECT) imaging, the meningeal dissemination was identified successfully by (111)In-labeled A(3)B-type lactosome, which was superior to (201)TlCl in regard of the imaging contrast. The (111)In-labeled A(3)B-type lactosome was also potential in imaging selectively of bone metastasis at mandible, whilst a nonspecific imaging of the whole bone was obtained by the SPECT imaging using (99m)Tc-HMDP. The polymeric micelle of the A(3)B-type lactosome was therefore found to be effective as a vehicle of (111)In to be targeted to meningeal dissemination and bone metastasis. |
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