Variability in Intrahousehold Transmission of Ebola Virus, and Estimation of the Household Secondary Attack Rate

Transmission between family members accounts for most Ebola virus transmission, but little is known about determinants of intrahousehold spread. From detailed exposure histories, intrahousehold transmission chains were created for 94 households of Ebola survivors in Sierra Leone: 109 (co-)primary ca...

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Detalles Bibliográficos
Autores principales: Glynn, Judith R, Bower, Hilary, Johnson, Sembia, Turay, Cecilia, Sesay, Daniel, Mansaray, Saidu H, Kamara, Osman, Kamara, Alie Joshua, Bangura, Mohammed S, Checchi, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853870/
https://www.ncbi.nlm.nih.gov/pubmed/29140442
http://dx.doi.org/10.1093/infdis/jix579
Descripción
Sumario:Transmission between family members accounts for most Ebola virus transmission, but little is known about determinants of intrahousehold spread. From detailed exposure histories, intrahousehold transmission chains were created for 94 households of Ebola survivors in Sierra Leone: 109 (co-)primary cases gave rise to 317 subsequent cases (0–100% of those exposed). Larger households were more likely to have subsequent cases, and the proportion of household members affected depended on individual and household-level factors. More transmissions occurred from older than from younger cases, and from those with more severe disease. The estimated household secondary attack rate was 18%.

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