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Mast cells co-expressing CD68 and inorganic polyphosphate are linked with colorectal cancer
Inflammation is a hallmark of colorectal cancer (CRC). Neutrophils are well-known mediators in tumor biology but their role in solid tumors, including CRC, was redefined by neutrophil extracellular traps (NETs). Given that it was recently demonstrated that platelet-derived polyP primes neutrophils t...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854234/ https://www.ncbi.nlm.nih.gov/pubmed/29543850 http://dx.doi.org/10.1371/journal.pone.0193089 |
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author | Arelaki, Stella Arampatzioglou, Athanasios Kambas, Konstantinos Sivridis, Efthimios Giatromanolaki, Alexandra Ritis, Konstantinos |
author_facet | Arelaki, Stella Arampatzioglou, Athanasios Kambas, Konstantinos Sivridis, Efthimios Giatromanolaki, Alexandra Ritis, Konstantinos |
author_sort | Arelaki, Stella |
collection | PubMed |
description | Inflammation is a hallmark of colorectal cancer (CRC). Neutrophils are well-known mediators in tumor biology but their role in solid tumors, including CRC, was redefined by neutrophil extracellular traps (NETs). Given that it was recently demonstrated that platelet-derived polyP primes neutrophils to release NETs, we examined surgical specimens from CRC to investigate the presence of polyP, as a possible NET inducer. Biopsies with adenomas, hyperplastic polyps, inflammatory bowel disease and healthy colon tissues were used as controls. In all cases, the presence of polyP was apparent, with the main source of polyP being the mast cells. In all CRC and all adenomas with high-grade dysplasia, a substantial number of mast cells, more than 50%, co-expressed intracellularly polyP with CD68 surface antigen (CD68+), but this was not the case in the other examined disorders. PolyP-expressing mast cells were detected in close proximity with tumor cells and neutrophils, suggesting polyP expression by CD68+ mast cells among the stimuli which prime neutrophils to release NETs, in CRC. Moreover, the detection of CD68+ polyP-expressing mast cells could represent a potential prognostic marker in colorectal adenomas and/or carcinomas. |
format | Online Article Text |
id | pubmed-5854234 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-58542342018-03-23 Mast cells co-expressing CD68 and inorganic polyphosphate are linked with colorectal cancer Arelaki, Stella Arampatzioglou, Athanasios Kambas, Konstantinos Sivridis, Efthimios Giatromanolaki, Alexandra Ritis, Konstantinos PLoS One Research Article Inflammation is a hallmark of colorectal cancer (CRC). Neutrophils are well-known mediators in tumor biology but their role in solid tumors, including CRC, was redefined by neutrophil extracellular traps (NETs). Given that it was recently demonstrated that platelet-derived polyP primes neutrophils to release NETs, we examined surgical specimens from CRC to investigate the presence of polyP, as a possible NET inducer. Biopsies with adenomas, hyperplastic polyps, inflammatory bowel disease and healthy colon tissues were used as controls. In all cases, the presence of polyP was apparent, with the main source of polyP being the mast cells. In all CRC and all adenomas with high-grade dysplasia, a substantial number of mast cells, more than 50%, co-expressed intracellularly polyP with CD68 surface antigen (CD68+), but this was not the case in the other examined disorders. PolyP-expressing mast cells were detected in close proximity with tumor cells and neutrophils, suggesting polyP expression by CD68+ mast cells among the stimuli which prime neutrophils to release NETs, in CRC. Moreover, the detection of CD68+ polyP-expressing mast cells could represent a potential prognostic marker in colorectal adenomas and/or carcinomas. Public Library of Science 2018-03-15 /pmc/articles/PMC5854234/ /pubmed/29543850 http://dx.doi.org/10.1371/journal.pone.0193089 Text en © 2018 Arelaki et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Arelaki, Stella Arampatzioglou, Athanasios Kambas, Konstantinos Sivridis, Efthimios Giatromanolaki, Alexandra Ritis, Konstantinos Mast cells co-expressing CD68 and inorganic polyphosphate are linked with colorectal cancer |
title | Mast cells co-expressing CD68 and inorganic polyphosphate are linked with colorectal cancer |
title_full | Mast cells co-expressing CD68 and inorganic polyphosphate are linked with colorectal cancer |
title_fullStr | Mast cells co-expressing CD68 and inorganic polyphosphate are linked with colorectal cancer |
title_full_unstemmed | Mast cells co-expressing CD68 and inorganic polyphosphate are linked with colorectal cancer |
title_short | Mast cells co-expressing CD68 and inorganic polyphosphate are linked with colorectal cancer |
title_sort | mast cells co-expressing cd68 and inorganic polyphosphate are linked with colorectal cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854234/ https://www.ncbi.nlm.nih.gov/pubmed/29543850 http://dx.doi.org/10.1371/journal.pone.0193089 |
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