Targeting focal adhesion kinase overcomes erlotinib resistance in smoke induced lung cancer by altering phosphorylation of epidermal growth factor receptor

EGFR-based targeted therapies have shown limited success in smokers. Identification of alternate signaling mechanism(s) leading to TKI resistance in smokers is critically important. We observed increased resistance to erlotinib in H358 NSCLC (non-small cell lung carcinoma) cells chronically exposed...

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Detalles Bibliográficos
Autores principales: Solanki, Hitendra S., Raja, Remya, Zhavoronkov, Alex, Ozerov, Ivan V., Artemov, Artem V., Advani, Jayshree, Radhakrishnan, Aneesha, Babu, Niraj, Puttamallesh, Vinuth N., Syed, Nazia, Nanjappa, Vishalakshi, Subbannayya, Tejaswini, Sahasrabuddhe, Nandini A., Patil, Arun H., Prasad, T.S. Keshava, Gaykalova, Daria, Chang, Xiaofei, Sathyendran, Rachana, Mathur, Premendu Prakash, Rangarajan, Annapoorni, Sidransky, David, Pandey, Akhilesh, Izumchenko, Evgeny, Gowda, Harsha, Chatterjee, Aditi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854290/
https://www.ncbi.nlm.nih.gov/pubmed/29556515
http://dx.doi.org/10.18632/oncoscience.395

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