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Influence of Acute Antipsychotic Treatment on Cardiorespiratory Coupling and Heart Rate Variability

A major contributing factor associated with increased cardiac mortality in patients with schizophrenia (SCZ) seems to be a dysfunction of the autonomic nervous system (ANS). The link between ANS dysfunction and SCZ is multifactorial, but some reports suggest that the use of antipsychotics could be i...

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Autores principales: Aguirre, Roboam R, Mustafa, Mixel Z, Dumenigo, Alessandra, Schulz, Steffen, Voss, Andreas, Goubran, Bishoy, Dumenigo, Rhaisa, Sanchez-Gonzalez, Marcos A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854318/
https://www.ncbi.nlm.nih.gov/pubmed/29552429
http://dx.doi.org/10.7759/cureus.2066
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author Aguirre, Roboam R
Mustafa, Mixel Z
Dumenigo, Alessandra
Schulz, Steffen
Voss, Andreas
Goubran, Bishoy
Dumenigo, Rhaisa
Sanchez-Gonzalez, Marcos A
author_facet Aguirre, Roboam R
Mustafa, Mixel Z
Dumenigo, Alessandra
Schulz, Steffen
Voss, Andreas
Goubran, Bishoy
Dumenigo, Rhaisa
Sanchez-Gonzalez, Marcos A
author_sort Aguirre, Roboam R
collection PubMed
description A major contributing factor associated with increased cardiac mortality in patients with schizophrenia (SCZ) seems to be a dysfunction of the autonomic nervous system (ANS). The link between ANS dysfunction and SCZ is multifactorial, but some reports suggest that the use of antipsychotics could be implicated. This case illustrates the time course of autonomic improvement in response to antipsychotic treatment in an inpatient with SCZ in acute psychosis. To this end, we documented markers of autonomic function during hospitalization. Heart rate variability (HRV; cardiac autonomic modulation) analysis showed an increased variability over time (from Day 1 to Day 3), with strongest reaction at Day 3. The respiration analysis showed an increased respiratory variability over time (from Day 1 to Day 3) suggesting improved autonomic modulation in response to the pharmacotherapy. Cardiorespiratory coupling (CRC; surrogate of cardiorespiratory synchrony and cardiovagal modulation) showed an increasing influence of heart rate on respiration and increased from Day 1 to Day 3. The concurrent improvement of psychosis and autonomic function in response to antipsychotic treatment in this patient suggest a potential cardio protective role of antipsychotics in the acute setting. Prospective trials aimed at examining the cardiovascular implications of acute psychosis treatment in patients with schizophrenia are warranted.
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spelling pubmed-58543182018-03-16 Influence of Acute Antipsychotic Treatment on Cardiorespiratory Coupling and Heart Rate Variability Aguirre, Roboam R Mustafa, Mixel Z Dumenigo, Alessandra Schulz, Steffen Voss, Andreas Goubran, Bishoy Dumenigo, Rhaisa Sanchez-Gonzalez, Marcos A Cureus Cardiology A major contributing factor associated with increased cardiac mortality in patients with schizophrenia (SCZ) seems to be a dysfunction of the autonomic nervous system (ANS). The link between ANS dysfunction and SCZ is multifactorial, but some reports suggest that the use of antipsychotics could be implicated. This case illustrates the time course of autonomic improvement in response to antipsychotic treatment in an inpatient with SCZ in acute psychosis. To this end, we documented markers of autonomic function during hospitalization. Heart rate variability (HRV; cardiac autonomic modulation) analysis showed an increased variability over time (from Day 1 to Day 3), with strongest reaction at Day 3. The respiration analysis showed an increased respiratory variability over time (from Day 1 to Day 3) suggesting improved autonomic modulation in response to the pharmacotherapy. Cardiorespiratory coupling (CRC; surrogate of cardiorespiratory synchrony and cardiovagal modulation) showed an increasing influence of heart rate on respiration and increased from Day 1 to Day 3. The concurrent improvement of psychosis and autonomic function in response to antipsychotic treatment in this patient suggest a potential cardio protective role of antipsychotics in the acute setting. Prospective trials aimed at examining the cardiovascular implications of acute psychosis treatment in patients with schizophrenia are warranted. Cureus 2018-01-15 /pmc/articles/PMC5854318/ /pubmed/29552429 http://dx.doi.org/10.7759/cureus.2066 Text en Copyright © 2018, Aguirre et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiology
Aguirre, Roboam R
Mustafa, Mixel Z
Dumenigo, Alessandra
Schulz, Steffen
Voss, Andreas
Goubran, Bishoy
Dumenigo, Rhaisa
Sanchez-Gonzalez, Marcos A
Influence of Acute Antipsychotic Treatment on Cardiorespiratory Coupling and Heart Rate Variability
title Influence of Acute Antipsychotic Treatment on Cardiorespiratory Coupling and Heart Rate Variability
title_full Influence of Acute Antipsychotic Treatment on Cardiorespiratory Coupling and Heart Rate Variability
title_fullStr Influence of Acute Antipsychotic Treatment on Cardiorespiratory Coupling and Heart Rate Variability
title_full_unstemmed Influence of Acute Antipsychotic Treatment on Cardiorespiratory Coupling and Heart Rate Variability
title_short Influence of Acute Antipsychotic Treatment on Cardiorespiratory Coupling and Heart Rate Variability
title_sort influence of acute antipsychotic treatment on cardiorespiratory coupling and heart rate variability
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854318/
https://www.ncbi.nlm.nih.gov/pubmed/29552429
http://dx.doi.org/10.7759/cureus.2066
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