Analytical validation of a next generation sequencing liquid biopsy assay for high sensitivity broad molecular profiling

Circulating tumor DNA (ctDNA) analysis is being incorporated into cancer care; notably in profiling patients to guide treatment decisions. Responses to targeted therapies have been observed in patients with actionable mutations detected in plasma DNA at variant allele fractions (VAFs) below 0.5%. Hi...

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Detalles Bibliográficos
Autores principales: Plagnol, Vincent, Woodhouse, Samuel, Howarth, Karen, Lensing, Stefanie, Smith, Matt, Epstein, Michael, Madi, Mikidache, Smalley, Sarah, Leroy, Catherine, Hinton, Jonathan, de Kievit, Frank, Musgrave-Brown, Esther, Herd, Colin, Baker-Neblett, Katherine, Brennan, Will, Dimitrov, Peter, Campbell, Nathan, Morris, Clive, Rosenfeld, Nitzan, Clark, James, Gale, Davina, Platt, Jamie, Calaway, John, Jones, Greg, Forshew, Tim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854321/
https://www.ncbi.nlm.nih.gov/pubmed/29543828
http://dx.doi.org/10.1371/journal.pone.0193802

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