Nuclear quiescence and histone hyper-acetylation jointly improve protamine-mediated nuclear remodeling in sheep fibroblasts

Recently we have demonstrated the possibility to replace histones with protamine, through the heterologous expression of human protamine 1 (hPrm1) gene in sheep fibroblasts. Here we have optimized protaminization of somatic nucleus by adjusting the best concentration and exposure time to trichostati...

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Detalles Bibliográficos
Autores principales: Palazzese, Luca, Czernik, Marta, Iuso, Domenico, Toschi, Paola, Loi, Pasqualino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854339/
https://www.ncbi.nlm.nih.gov/pubmed/29543876
http://dx.doi.org/10.1371/journal.pone.0193954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854339/
https://www.ncbi.nlm.nih.gov/pubmed/29543876
http://dx.doi.org/10.1371/journal.pone.0193954

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