Viral manipulation of STAT3: Evade, exploit, and injure

Signal transducer and activator of transcription 3 (STAT3) is a key regulator of numerous physiological functions, including the immune response. As pathogens elicit an acute phase response with concerted activation of STAT3, they are confronted with two evolutionary options: either curtail it or em...

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Detalles Bibliográficos
Autores principales: Roca Suarez, Armando Andres, Van Renne, Nicolaas, Baumert, Thomas F., Lupberger, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854428/
https://www.ncbi.nlm.nih.gov/pubmed/29543893
http://dx.doi.org/10.1371/journal.ppat.1006839
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author Roca Suarez, Armando Andres
Van Renne, Nicolaas
Baumert, Thomas F.
Lupberger, Joachim
author_facet Roca Suarez, Armando Andres
Van Renne, Nicolaas
Baumert, Thomas F.
Lupberger, Joachim
author_sort Roca Suarez, Armando Andres
collection PubMed
description Signal transducer and activator of transcription 3 (STAT3) is a key regulator of numerous physiological functions, including the immune response. As pathogens elicit an acute phase response with concerted activation of STAT3, they are confronted with two evolutionary options: either curtail it or employ it. This has important consequences for the host, since abnormal STAT3 function is associated with cancer development and other diseases. This review provides a comprehensive outline of how human viruses cope with STAT3-mediated inflammation and how this affects the host. Finally, we discuss STAT3 as a potential target for antiviral therapy.
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spelling pubmed-58544282018-03-28 Viral manipulation of STAT3: Evade, exploit, and injure Roca Suarez, Armando Andres Van Renne, Nicolaas Baumert, Thomas F. Lupberger, Joachim PLoS Pathog Review Signal transducer and activator of transcription 3 (STAT3) is a key regulator of numerous physiological functions, including the immune response. As pathogens elicit an acute phase response with concerted activation of STAT3, they are confronted with two evolutionary options: either curtail it or employ it. This has important consequences for the host, since abnormal STAT3 function is associated with cancer development and other diseases. This review provides a comprehensive outline of how human viruses cope with STAT3-mediated inflammation and how this affects the host. Finally, we discuss STAT3 as a potential target for antiviral therapy. Public Library of Science 2018-03-15 /pmc/articles/PMC5854428/ /pubmed/29543893 http://dx.doi.org/10.1371/journal.ppat.1006839 Text en © 2018 Roca Suarez et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Roca Suarez, Armando Andres
Van Renne, Nicolaas
Baumert, Thomas F.
Lupberger, Joachim
Viral manipulation of STAT3: Evade, exploit, and injure
title Viral manipulation of STAT3: Evade, exploit, and injure
title_full Viral manipulation of STAT3: Evade, exploit, and injure
title_fullStr Viral manipulation of STAT3: Evade, exploit, and injure
title_full_unstemmed Viral manipulation of STAT3: Evade, exploit, and injure
title_short Viral manipulation of STAT3: Evade, exploit, and injure
title_sort viral manipulation of stat3: evade, exploit, and injure
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854428/
https://www.ncbi.nlm.nih.gov/pubmed/29543893
http://dx.doi.org/10.1371/journal.ppat.1006839
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