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Drosophila Fezf coordinates laminar-specific connectivity through cell-intrinsic and cell-extrinsic mechanisms
Laminar arrangement of neural connections is a fundamental feature of neural circuit organization. Identifying mechanisms that coordinate neural connections within correct layers is thus vital for understanding how neural circuits are assembled. In the medulla of the Drosophila visual system neurons...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854465/ https://www.ncbi.nlm.nih.gov/pubmed/29513217 http://dx.doi.org/10.7554/eLife.33962 |
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author | Peng, Jing Santiago, Ivan J Ahn, Curie Gur, Burak Tsui, C Kimberly Su, Zhixiao Xu, Chundi Karakhanyan, Aziz Silies, Marion Pecot, Matthew Y |
author_facet | Peng, Jing Santiago, Ivan J Ahn, Curie Gur, Burak Tsui, C Kimberly Su, Zhixiao Xu, Chundi Karakhanyan, Aziz Silies, Marion Pecot, Matthew Y |
author_sort | Peng, Jing |
collection | PubMed |
description | Laminar arrangement of neural connections is a fundamental feature of neural circuit organization. Identifying mechanisms that coordinate neural connections within correct layers is thus vital for understanding how neural circuits are assembled. In the medulla of the Drosophila visual system neurons form connections within ten parallel layers. The M3 layer receives input from two neuron types that sequentially innervate M3 during development. Here we show that M3-specific innervation by both neurons is coordinated by Drosophila Fezf (dFezf), a conserved transcription factor that is selectively expressed by the earlier targeting input neuron. In this cell, dFezf instructs layer specificity and activates the expression of a secreted molecule (Netrin) that regulates the layer specificity of the other input neuron. We propose that employment of transcriptional modules that cell-intrinsically target neurons to specific layers, and cell-extrinsically recruit other neurons is a general mechanism for building layered networks of neural connections. |
format | Online Article Text |
id | pubmed-5854465 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-58544652018-03-20 Drosophila Fezf coordinates laminar-specific connectivity through cell-intrinsic and cell-extrinsic mechanisms Peng, Jing Santiago, Ivan J Ahn, Curie Gur, Burak Tsui, C Kimberly Su, Zhixiao Xu, Chundi Karakhanyan, Aziz Silies, Marion Pecot, Matthew Y eLife Neuroscience Laminar arrangement of neural connections is a fundamental feature of neural circuit organization. Identifying mechanisms that coordinate neural connections within correct layers is thus vital for understanding how neural circuits are assembled. In the medulla of the Drosophila visual system neurons form connections within ten parallel layers. The M3 layer receives input from two neuron types that sequentially innervate M3 during development. Here we show that M3-specific innervation by both neurons is coordinated by Drosophila Fezf (dFezf), a conserved transcription factor that is selectively expressed by the earlier targeting input neuron. In this cell, dFezf instructs layer specificity and activates the expression of a secreted molecule (Netrin) that regulates the layer specificity of the other input neuron. We propose that employment of transcriptional modules that cell-intrinsically target neurons to specific layers, and cell-extrinsically recruit other neurons is a general mechanism for building layered networks of neural connections. eLife Sciences Publications, Ltd 2018-03-07 /pmc/articles/PMC5854465/ /pubmed/29513217 http://dx.doi.org/10.7554/eLife.33962 Text en © 2018, Peng et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Peng, Jing Santiago, Ivan J Ahn, Curie Gur, Burak Tsui, C Kimberly Su, Zhixiao Xu, Chundi Karakhanyan, Aziz Silies, Marion Pecot, Matthew Y Drosophila Fezf coordinates laminar-specific connectivity through cell-intrinsic and cell-extrinsic mechanisms |
title | Drosophila Fezf coordinates laminar-specific connectivity through cell-intrinsic and cell-extrinsic mechanisms |
title_full | Drosophila Fezf coordinates laminar-specific connectivity through cell-intrinsic and cell-extrinsic mechanisms |
title_fullStr | Drosophila Fezf coordinates laminar-specific connectivity through cell-intrinsic and cell-extrinsic mechanisms |
title_full_unstemmed | Drosophila Fezf coordinates laminar-specific connectivity through cell-intrinsic and cell-extrinsic mechanisms |
title_short | Drosophila Fezf coordinates laminar-specific connectivity through cell-intrinsic and cell-extrinsic mechanisms |
title_sort | drosophila fezf coordinates laminar-specific connectivity through cell-intrinsic and cell-extrinsic mechanisms |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854465/ https://www.ncbi.nlm.nih.gov/pubmed/29513217 http://dx.doi.org/10.7554/eLife.33962 |
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