Controlled drug delivery vehicles for cancer treatment and their performance

Although conventional chemotherapy has been successful to some extent, the main drawbacks of chemotherapy are its poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, development of multiple drug resistance, and non-specific targeting. The main aim in the deve...

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Autores principales: Senapati, Sudipta, Mahanta, Arun Kumar, Kumar, Sunil, Maiti, Pralay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854578/
https://www.ncbi.nlm.nih.gov/pubmed/29560283
http://dx.doi.org/10.1038/s41392-017-0004-3
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author Senapati, Sudipta
Mahanta, Arun Kumar
Kumar, Sunil
Maiti, Pralay
author_facet Senapati, Sudipta
Mahanta, Arun Kumar
Kumar, Sunil
Maiti, Pralay
author_sort Senapati, Sudipta
collection PubMed
description Although conventional chemotherapy has been successful to some extent, the main drawbacks of chemotherapy are its poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, development of multiple drug resistance, and non-specific targeting. The main aim in the development of drug delivery vehicles is to successfully address these delivery-related problems and carry drugs to the desired sites of therapeutic action while reducing adverse side effects. In this review, we will discuss the different types of materials used as delivery vehicles for chemotherapeutic agents and their structural characteristics that improve the therapeutic efficacy of their drugs and will describe recent scientific advances in the area of chemotherapy, emphasizing challenges in cancer treatments.
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spelling pubmed-58545782018-03-20 Controlled drug delivery vehicles for cancer treatment and their performance Senapati, Sudipta Mahanta, Arun Kumar Kumar, Sunil Maiti, Pralay Signal Transduct Target Ther Review Article Although conventional chemotherapy has been successful to some extent, the main drawbacks of chemotherapy are its poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, development of multiple drug resistance, and non-specific targeting. The main aim in the development of drug delivery vehicles is to successfully address these delivery-related problems and carry drugs to the desired sites of therapeutic action while reducing adverse side effects. In this review, we will discuss the different types of materials used as delivery vehicles for chemotherapeutic agents and their structural characteristics that improve the therapeutic efficacy of their drugs and will describe recent scientific advances in the area of chemotherapy, emphasizing challenges in cancer treatments. Nature Publishing Group UK 2018-03-16 /pmc/articles/PMC5854578/ /pubmed/29560283 http://dx.doi.org/10.1038/s41392-017-0004-3 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Senapati, Sudipta
Mahanta, Arun Kumar
Kumar, Sunil
Maiti, Pralay
Controlled drug delivery vehicles for cancer treatment and their performance
title Controlled drug delivery vehicles for cancer treatment and their performance
title_full Controlled drug delivery vehicles for cancer treatment and their performance
title_fullStr Controlled drug delivery vehicles for cancer treatment and their performance
title_full_unstemmed Controlled drug delivery vehicles for cancer treatment and their performance
title_short Controlled drug delivery vehicles for cancer treatment and their performance
title_sort controlled drug delivery vehicles for cancer treatment and their performance
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854578/
https://www.ncbi.nlm.nih.gov/pubmed/29560283
http://dx.doi.org/10.1038/s41392-017-0004-3
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AT maitipralay controlleddrugdeliveryvehiclesforcancertreatmentandtheirperformance

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