Cargando…
Electroencephalographic derived network differences in Lewy body dementia compared to Alzheimer’s disease patients
Dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD) require differential management despite presenting with symptomatic overlap. Currently, there is a need of inexpensive DLB biomarkers which can be fulfilled by electroencephalography (EEG). In this regard, an established electrophysiologic...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854590/ https://www.ncbi.nlm.nih.gov/pubmed/29545639 http://dx.doi.org/10.1038/s41598-018-22984-5 |
_version_ | 1783306932976615424 |
---|---|
author | Peraza, Luis R. Cromarty, Ruth Kobeleva, Xenia Firbank, Michael J. Killen, Alison Graziadio, Sara Thomas, Alan J. O’Brien, John T. Taylor, John-Paul |
author_facet | Peraza, Luis R. Cromarty, Ruth Kobeleva, Xenia Firbank, Michael J. Killen, Alison Graziadio, Sara Thomas, Alan J. O’Brien, John T. Taylor, John-Paul |
author_sort | Peraza, Luis R. |
collection | PubMed |
description | Dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD) require differential management despite presenting with symptomatic overlap. Currently, there is a need of inexpensive DLB biomarkers which can be fulfilled by electroencephalography (EEG). In this regard, an established electrophysiological difference in DLB is a decrease of dominant frequency (DF)—the frequency with the highest signal power between 4 and 15 Hz. Here, we investigated network connectivity in EEG signals acquired from DLB patients, and whether these networks were able to differentiate DLB from healthy controls (HCs) and associated dementias. We analysed EEG recordings from old adults: HCs, AD, DLB and Parkinson’s disease dementia (PDD) patients. Brain networks were assessed with the minimum spanning tree (MST) within six EEG bands: delta, theta, high-theta, alpha, beta and DF. Patients showed lower alpha band connectivity and lower DF than HCs. DLB and PDD showed a randomised MST compared with HCs and AD in high-theta and alpha but not in DF. The MST randomisation in DLB and PDD reflects decreased brain efficiency as well as impaired neural synchronisation. However, the lack of network topology differences at the DF between all dementia groups and HCs may indicate a compensatory response of the brain to the neuropathology. |
format | Online Article Text |
id | pubmed-5854590 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-58545902018-03-22 Electroencephalographic derived network differences in Lewy body dementia compared to Alzheimer’s disease patients Peraza, Luis R. Cromarty, Ruth Kobeleva, Xenia Firbank, Michael J. Killen, Alison Graziadio, Sara Thomas, Alan J. O’Brien, John T. Taylor, John-Paul Sci Rep Article Dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD) require differential management despite presenting with symptomatic overlap. Currently, there is a need of inexpensive DLB biomarkers which can be fulfilled by electroencephalography (EEG). In this regard, an established electrophysiological difference in DLB is a decrease of dominant frequency (DF)—the frequency with the highest signal power between 4 and 15 Hz. Here, we investigated network connectivity in EEG signals acquired from DLB patients, and whether these networks were able to differentiate DLB from healthy controls (HCs) and associated dementias. We analysed EEG recordings from old adults: HCs, AD, DLB and Parkinson’s disease dementia (PDD) patients. Brain networks were assessed with the minimum spanning tree (MST) within six EEG bands: delta, theta, high-theta, alpha, beta and DF. Patients showed lower alpha band connectivity and lower DF than HCs. DLB and PDD showed a randomised MST compared with HCs and AD in high-theta and alpha but not in DF. The MST randomisation in DLB and PDD reflects decreased brain efficiency as well as impaired neural synchronisation. However, the lack of network topology differences at the DF between all dementia groups and HCs may indicate a compensatory response of the brain to the neuropathology. Nature Publishing Group UK 2018-03-15 /pmc/articles/PMC5854590/ /pubmed/29545639 http://dx.doi.org/10.1038/s41598-018-22984-5 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Peraza, Luis R. Cromarty, Ruth Kobeleva, Xenia Firbank, Michael J. Killen, Alison Graziadio, Sara Thomas, Alan J. O’Brien, John T. Taylor, John-Paul Electroencephalographic derived network differences in Lewy body dementia compared to Alzheimer’s disease patients |
title | Electroencephalographic derived network differences in Lewy body dementia compared to Alzheimer’s disease patients |
title_full | Electroencephalographic derived network differences in Lewy body dementia compared to Alzheimer’s disease patients |
title_fullStr | Electroencephalographic derived network differences in Lewy body dementia compared to Alzheimer’s disease patients |
title_full_unstemmed | Electroencephalographic derived network differences in Lewy body dementia compared to Alzheimer’s disease patients |
title_short | Electroencephalographic derived network differences in Lewy body dementia compared to Alzheimer’s disease patients |
title_sort | electroencephalographic derived network differences in lewy body dementia compared to alzheimer’s disease patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854590/ https://www.ncbi.nlm.nih.gov/pubmed/29545639 http://dx.doi.org/10.1038/s41598-018-22984-5 |
work_keys_str_mv | AT perazaluisr electroencephalographicderivednetworkdifferencesinlewybodydementiacomparedtoalzheimersdiseasepatients AT cromartyruth electroencephalographicderivednetworkdifferencesinlewybodydementiacomparedtoalzheimersdiseasepatients AT kobelevaxenia electroencephalographicderivednetworkdifferencesinlewybodydementiacomparedtoalzheimersdiseasepatients AT firbankmichaelj electroencephalographicderivednetworkdifferencesinlewybodydementiacomparedtoalzheimersdiseasepatients AT killenalison electroencephalographicderivednetworkdifferencesinlewybodydementiacomparedtoalzheimersdiseasepatients AT graziadiosara electroencephalographicderivednetworkdifferencesinlewybodydementiacomparedtoalzheimersdiseasepatients AT thomasalanj electroencephalographicderivednetworkdifferencesinlewybodydementiacomparedtoalzheimersdiseasepatients AT obrienjohnt electroencephalographicderivednetworkdifferencesinlewybodydementiacomparedtoalzheimersdiseasepatients AT taylorjohnpaul electroencephalographicderivednetworkdifferencesinlewybodydementiacomparedtoalzheimersdiseasepatients |