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TDP43 nuclear export and neurodegeneration in models of amyotrophic lateral sclerosis and frontotemporal dementia

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are progressive neurodegenerative disorders marked in most cases by the nuclear exclusion and cytoplasmic deposition of the RNA binding protein TDP43. We previously demonstrated that ALS–associated mutant TDP43 accumulates within...

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Detalles Bibliográficos
Autores principales:	Archbold, Hilary C., Jackson, Kasey L., Arora, Ayush, Weskamp, Kaitlin, Tank, Elizabeth M.-H., Li, Xingli, Miguez, Roberto, Dayton, Robert D., Tamir, Sharon, Klein, Ronald L., Barmada, Sami J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854632/ https://www.ncbi.nlm.nih.gov/pubmed/29545601 http://dx.doi.org/10.1038/s41598-018-22858-w

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