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Bacterial and Pneumocystis Infections in the Lungs of Gene-Knockout Rabbits with Severe Combined Immunodeficiency

Using the CRISPR/Cas9 gene-editing technology, we recently produced a number of rabbits with mutations in immune function genes, including FOXN1, PRKDC, RAG1, RAG2, and IL2RG. Seven founder knockout rabbits (F0) and three male IL2RG null (−/y) F1 animals demonstrated severe combined immunodeficiency...

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Detalles Bibliográficos
Autores principales:	Song, Jun, Wang, Guoshun, Hoenerhoff, Mark J., Ruan, Jinxue, Yang, Dongshan, Zhang, Jifeng, Yang, Jibing, Lester, Patrick A., Sigler, Robert, Bradley, Michael, Eckley, Samantha, Cornelius, Kelsey, Chen, Kong, Kolls, Jay K., Peng, Li, Ma, Liang, Chen, Yuqing Eugene, Sun, Fei, Xu, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854650/ https://www.ncbi.nlm.nih.gov/pubmed/29593714 http://dx.doi.org/10.3389/fimmu.2018.00429

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