Cargando…

Bacterial and Pneumocystis Infections in the Lungs of Gene-Knockout Rabbits with Severe Combined Immunodeficiency

Using the CRISPR/Cas9 gene-editing technology, we recently produced a number of rabbits with mutations in immune function genes, including FOXN1, PRKDC, RAG1, RAG2, and IL2RG. Seven founder knockout rabbits (F0) and three male IL2RG null (−/y) F1 animals demonstrated severe combined immunodeficiency...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Jun, Wang, Guoshun, Hoenerhoff, Mark J., Ruan, Jinxue, Yang, Dongshan, Zhang, Jifeng, Yang, Jibing, Lester, Patrick A., Sigler, Robert, Bradley, Michael, Eckley, Samantha, Cornelius, Kelsey, Chen, Kong, Kolls, Jay K., Peng, Li, Ma, Liang, Chen, Yuqing Eugene, Sun, Fei, Xu, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854650/ https://www.ncbi.nlm.nih.gov/pubmed/29593714 http://dx.doi.org/10.3389/fimmu.2018.00429

Ejemplares similares

Production of immunodeficient rabbits by multiplex embryo transfer and multiplex gene targeting
por: Song, Jun, et al.
Publicado: (2017)

Production of Apolipoprotein C-III Knockout Rabbits using Zinc Finger Nucleases
por: Yang, Dongshan, et al.
Publicado: (2013)

Development of the Nude Rabbit Model
por: Song, Jun, et al.
Publicado: (2021)

Production of CFTR-ΔF508 Rabbits
por: Yang, Dongshan, et al.
Publicado: (2021)

Genome engineering technologies in rabbits
por: Song, Jun, et al.
Publicado: (2021)

Efficient Gene Editing at Major CFTR Mutation Loci
por: Ruan, Jinxue, et al.
Publicado: (2019)

MiCas9 increases large size gene knock-in rates and reduces undesirable on-target and off-target indel edits
por: Ma, Linyuan, et al.
Publicado: (2020)

Identification and characterization of rabbit ROSA26 for gene knock-in and stable reporter gene expression
por: Yang, Dongshan, et al.
Publicado: (2016)

Delivery of CRISPR/Cas9 Plasmid DNA by Hyperbranched Polymeric Nanoparticles Enables Efficient Gene Editing
por: Xiu, Kemao, et al.
Publicado: (2022)

Gene Editing in Rabbits: Unique Opportunities for Translational Biomedical Research
por: Xu, Jie, et al.
Publicado: (2021)

EXPERIMENTAL PULMONARY PNEUMOCYSTIS CARINII INFECTION IN RABBITS
por: Sheldon, Walter H.
Publicado: (1959)

Toward a humanized mouse model of Pneumocystis pneumonia
por: Dai, Guixiang, et al.
Publicado: (2021)

Novel Pneumocystis Antigens for Seroprevalence Studies
por: Pungan, Dora, et al.
Publicado: (2023)

Germline IgM predicts T cell immunity to Pneumocystis
por: Noell, Kristin, et al.
Publicado: (2022)

Generation of knockout rabbits with X-linked severe combined immunodeficiency (X-SCID) using CRISPR/Cas9
por: Hashikawa, Yoshiko, et al.
Publicado: (2020)

Late Onset Combined Immunodeficiency Presenting with Recurrent Pneumocystis jiroveci Pneumonia
por: Papakonstantinou, Ilias, et al.
Publicado: (2014)

Recent Advances in Improving Gene-Editing Specificity through CRISPR–Cas9 Nuclease Engineering
por: Huang, Xiaoqiang, et al.
Publicado: (2022)

Transcriptomic and Proteomic Approaches to Finding Novel Diagnostic and Immunogenic Candidates in Pneumocystis
por: Eddens, Taylor, et al.
Publicado: (2019)

Efficacy and safety of trimethoprim-sulfamethoxazole for the prevention of pneumocystis pneumonia in human immunodeficiency virus-negative immunodeficient patients: A systematic review and meta-analysis
por: Li, Rui, et al.
Publicado: (2021)

Pneumocystis jirovecii Pneumonia and Human Immunodeficiency Virus Co-Infection in Western Iran
por: BOZORGOMID, Arezoo, et al.
Publicado: (2019)

Acquired Immunodeficiency from Maternal Chemotherapy and Severe Primary Pneumocystis Infection in an Infant
por: Lim, Adeline Yi Ling, et al.
Publicado: (2020)

A protracted course of Pneumocystis pneumonia in the setting of an immunosuppressed child with GMS-negative bronchoalveolar lavage
por: Eddens, Taylor, et al.
Publicado: (2016)

Targeted NGS-Based Analysis of Pneumocystis jirovecii Reveals Novel Genotypes
por: Pungan, Dora, et al.
Publicado: (2022)

Effect of Subcutaneous Anti-CD20 Antibody-Mediated B Cell Depletion on Susceptibility to Pneumocystis Infection in Mice
por: Dai, Guixiang, et al.
Publicado: (2021)

RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency
por: Song, Jun, et al.
Publicado: (2016)

Co-infection of Mycobacterium tuberculosis and Pneumocystis jirovecii in the Iranian Patients With Human Immunodeficiency Virus
por: Sheikholeslami, Maryam Fatemeh, et al.
Publicado: (2015)

Trends in the Epidemiology and Outcomes of Pneumocystis Pneumonia among Human Immunodeficiency Virus (HIV) Hospitalizations
por: Elango, Kalaimani, et al.
Publicado: (2022)

Pneumocystis Pneumonia Mimicking Atypical Pneumonia in a Patient With Human Immunodeficiency Virus Infection
por: Hashimoto, Takehiro, et al.
Publicado: (2022)

USH2A Gene Mutations in Rabbits Lead to Progressive Retinal Degeneration and Hearing Loss
por: Nguyen, Van Phuc, et al.
Publicado: (2023)

Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene
por: Xu, Jie, et al.
Publicado: (2021)

Pneumocystis Pneumonia in Human Immunodeficiency Virus–infected Adults and Adolescents: Current Concepts and Future Directions
por: Tasaka, Sadatomo
Publicado: (2015)

Case Report: Pneumonia in a Patient With Combined Variable Immunodeficiency: COVID-19 or Pneumocystis Pneumonia?
por: Tehrani, Shabnam, et al.
Publicado: (2022)

Clinical and translational research in Pneumocystis and Pneumocystis pneumonia
por: Huang, L.
Publicado: (2011)

The Role of the Respiratory Therapy Team in the Treatment of Patients With Acquired Immunodeficiency Syndrome Complicated With Pneumocystis Pneumonia Undergoing Mechanical Ventilation
por: Gu, Yanmei, et al.
Publicado: (2022)

Lymphocyte apoptosis in murine Pneumocystis pneumonia
por: Shi, Xin, et al.
Publicado: (2009)

Conserved natural IgM antibodies mediate innate and adaptive immunity against the opportunistic fungus Pneumocystis murina
por: Rapaka, Rekha R., et al.
Publicado: (2010)

Gene analysis of seven cases of primary immunodeficiency
por: Zhu, Ying, et al.
Publicado: (2020)

An infant with X‐linked anhidrotic ectodermal dysplasia with immunodeficiency presenting with Pneumocystis pneumonia: A case report
por: Toyohara, Miwako, et al.
Publicado: (2021)

Pneumocystis jirovecii and SARS-CoV-2 Coinfection as Presentation of X-linked Severe Combined Immunodeficiency
por: Toledano-Revenga, Javier, et al.
Publicado: (2023)

Treatment of Pneumocystis jirovecii pneumonia in non-human immunodeficiency virus-infected patients using a combination of trimethoprim-sulfamethoxazole and caspofungin
por: Wu, Huan-Huan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_srad1e3mk1jj2sfh2jm4s66ie8