Safety, Tolerability and Pharmacokinetics of Oral BI 425809, a Glycine Transporter 1 Inhibitor, in Healthy Male Volunteers: A Partially Randomised, Single-Blind, Placebo-Controlled, First-in-Human Study

BACKGROUND AND OBJECTIVES: Schizophrenia and Alzheimer’s disease are characterised by glutamatergic pathway abnormalities related to N-methyl-d-aspartate (NMDA) receptor hypofunction and cognitive impairment. Glycine is an NMDA receptor co-agonist; inhibition of glycine transporter 1 (GlyT1) should...

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Detalles Bibliográficos
Autores principales: Moschetti, Viktoria, Desch, Michael, Goetz, Sophia, Liesenfeld, Karl-Heinz, Rosenbrock, Holger, Kammerer, Klaus-Peter, Wunderlich, Glen, Wind, Sven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854750/
https://www.ncbi.nlm.nih.gov/pubmed/29076028
http://dx.doi.org/10.1007/s13318-017-0440-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854750/
https://www.ncbi.nlm.nih.gov/pubmed/29076028
http://dx.doi.org/10.1007/s13318-017-0440-z

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