Surgical thyroparathyroidectomy prevents progression of 5TGM1 murine multiple myeloma in vivo

The 5TGM1 multiple myeloma transplanted C57BL6/KaLwRij model recapitulates many disease features including monoclonal paraprotein production as well as the development of osteolytic bone lesions. Since a significant association between serum parathyroid hormone PTH variations, bone anabolism and mye...

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Autores principales: Zangari, Maurizio, Yoo, Hanna, Shin, Ik Jae, Yoon, Donghoon, Suva, Larry J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854927/
https://www.ncbi.nlm.nih.gov/pubmed/29556454
http://dx.doi.org/10.1016/j.jbo.2018.02.005
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author Zangari, Maurizio
Yoo, Hanna
Shin, Ik Jae
Yoon, Donghoon
Suva, Larry J.
author_facet Zangari, Maurizio
Yoo, Hanna
Shin, Ik Jae
Yoon, Donghoon
Suva, Larry J.
author_sort Zangari, Maurizio
collection PubMed
description The 5TGM1 multiple myeloma transplanted C57BL6/KaLwRij model recapitulates many disease features including monoclonal paraprotein production as well as the development of osteolytic bone lesions. Since a significant association between serum parathyroid hormone PTH variations, bone anabolism and myeloma progression in patients receiving proteasome inhibitors exists, this study investigated the effect of the PTH axis on murine myeloma development in vivo. C57BL6/KaLwRij myeloma-bearing mice underwent thyroparathyroidectomy (TPTX) before and after 5TGM1 cell transplantation. TPTX significantly and permanently inhibited 5TGM1 myeloma cell engraftment and prevented multiple myeloma growth and progression. These data support the hypothesis that the PTH axis is an important mediator of myeloma bone disease.
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spelling pubmed-58549272018-03-19 Surgical thyroparathyroidectomy prevents progression of 5TGM1 murine multiple myeloma in vivo Zangari, Maurizio Yoo, Hanna Shin, Ik Jae Yoon, Donghoon Suva, Larry J. J Bone Oncol Review Article The 5TGM1 multiple myeloma transplanted C57BL6/KaLwRij model recapitulates many disease features including monoclonal paraprotein production as well as the development of osteolytic bone lesions. Since a significant association between serum parathyroid hormone PTH variations, bone anabolism and myeloma progression in patients receiving proteasome inhibitors exists, this study investigated the effect of the PTH axis on murine myeloma development in vivo. C57BL6/KaLwRij myeloma-bearing mice underwent thyroparathyroidectomy (TPTX) before and after 5TGM1 cell transplantation. TPTX significantly and permanently inhibited 5TGM1 myeloma cell engraftment and prevented multiple myeloma growth and progression. These data support the hypothesis that the PTH axis is an important mediator of myeloma bone disease. Elsevier 2018-02-23 /pmc/articles/PMC5854927/ /pubmed/29556454 http://dx.doi.org/10.1016/j.jbo.2018.02.005 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Zangari, Maurizio
Yoo, Hanna
Shin, Ik Jae
Yoon, Donghoon
Suva, Larry J.
Surgical thyroparathyroidectomy prevents progression of 5TGM1 murine multiple myeloma in vivo
title Surgical thyroparathyroidectomy prevents progression of 5TGM1 murine multiple myeloma in vivo
title_full Surgical thyroparathyroidectomy prevents progression of 5TGM1 murine multiple myeloma in vivo
title_fullStr Surgical thyroparathyroidectomy prevents progression of 5TGM1 murine multiple myeloma in vivo
title_full_unstemmed Surgical thyroparathyroidectomy prevents progression of 5TGM1 murine multiple myeloma in vivo
title_short Surgical thyroparathyroidectomy prevents progression of 5TGM1 murine multiple myeloma in vivo
title_sort surgical thyroparathyroidectomy prevents progression of 5tgm1 murine multiple myeloma in vivo
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854927/
https://www.ncbi.nlm.nih.gov/pubmed/29556454
http://dx.doi.org/10.1016/j.jbo.2018.02.005
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