Cargando…

Treatment effects of systematic two-stent and provisional stenting techniques in patients with complex coronary bifurcation lesions: rationale and design of a prospective, randomised and multicentre DEFINITION II trial

INTRODUCTION: Provisional stenting (PS) for simple coronary bifurcation lesions is the mainstay of treatment. A systematic two-stent approach is widely used for complex bifurcation lesions (CBLs). However, a randomised comparison of PS and two-stent techniques for CBLs has never been studied. Accord...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Jun-Jie, Gao, Xiao-Fei, Han, Ya-Ling, Kan, Jing, Tao, Ling, Ge, Zhen, Tresukosol, Damras, Lu, Shu, Ma, Li-Kun, Li, Feng, Yang, Song, Zhang, Jun, Munawar, Muhammad, Li, Li, Zhang, Rui-Yan, Zeng, He-Song, Santoso, Teguh, Xie, Ping, Jin, Ze-Ning, Han, Leng, Yin, Wei-Hsian, Qian, Xue-Song, Li, Qi-Hua, Hong, Lang, Paiboon, Chotnoparatpat, Wang, Yan, Liu, Li-Jun, Zhou, Lei, Wu, Xue-Ming, Wen, Shang-Yu, Lu, Qing-Hua, Yuan, Jun-Qiang, Chen, Liang-Long, Lavarra, Francesco, Rodríguez, Alfredo E, Zhou, Li-Min, Ding, Shi-Qin, Vichairuangthum, Kitigon, Zhu, Yuan-Sheng, Yu, Meng-Yue, Chen, Chan, Sheiban, Imad, Xia, Yong, Tian, Yu-Long, Shang, Zheng-Lu, Jiang, Qing, Zhen, Yong-Hong, Wang, Xin, Ye, Fei, Tian, Nai-Liang, Lin, Song, Liu, Zhi-Zhong, Chen, Shao-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855162/
https://www.ncbi.nlm.nih.gov/pubmed/29511018
http://dx.doi.org/10.1136/bmjopen-2017-020019
_version_ 1783307043684220928
author Zhang, Jun-Jie
Gao, Xiao-Fei
Han, Ya-Ling
Kan, Jing
Tao, Ling
Ge, Zhen
Tresukosol, Damras
Lu, Shu
Ma, Li-Kun
Li, Feng
Yang, Song
Zhang, Jun
Munawar, Muhammad
Li, Li
Zhang, Rui-Yan
Zeng, He-Song
Santoso, Teguh
Xie, Ping
Jin, Ze-Ning
Han, Leng
Yin, Wei-Hsian
Qian, Xue-Song
Li, Qi-Hua
Hong, Lang
Paiboon, Chotnoparatpat
Wang, Yan
Liu, Li-Jun
Zhou, Lei
Wu, Xue-Ming
Wen, Shang-Yu
Lu, Qing-Hua
Yuan, Jun-Qiang
Chen, Liang-Long
Lavarra, Francesco
Rodríguez, Alfredo E
Zhou, Li-Min
Ding, Shi-Qin
Vichairuangthum, Kitigon
Zhu, Yuan-Sheng
Yu, Meng-Yue
Chen, Chan
Sheiban, Imad
Xia, Yong
Tian, Yu-Long
Shang, Zheng-Lu
Jiang, Qing
Zhen, Yong-Hong
Wang, Xin
Ye, Fei
Tian, Nai-Liang
Lin, Song
Liu, Zhi-Zhong
Chen, Shao-Liang
author_facet Zhang, Jun-Jie
Gao, Xiao-Fei
Han, Ya-Ling
Kan, Jing
Tao, Ling
Ge, Zhen
Tresukosol, Damras
Lu, Shu
Ma, Li-Kun
Li, Feng
Yang, Song
Zhang, Jun
Munawar, Muhammad
Li, Li
Zhang, Rui-Yan
Zeng, He-Song
Santoso, Teguh
Xie, Ping
Jin, Ze-Ning
Han, Leng
Yin, Wei-Hsian
Qian, Xue-Song
Li, Qi-Hua
Hong, Lang
Paiboon, Chotnoparatpat
Wang, Yan
Liu, Li-Jun
Zhou, Lei
Wu, Xue-Ming
Wen, Shang-Yu
Lu, Qing-Hua
Yuan, Jun-Qiang
Chen, Liang-Long
Lavarra, Francesco
Rodríguez, Alfredo E
Zhou, Li-Min
Ding, Shi-Qin
Vichairuangthum, Kitigon
Zhu, Yuan-Sheng
Yu, Meng-Yue
Chen, Chan
Sheiban, Imad
Xia, Yong
Tian, Yu-Long
Shang, Zheng-Lu
Jiang, Qing
Zhen, Yong-Hong
Wang, Xin
Ye, Fei
Tian, Nai-Liang
Lin, Song
Liu, Zhi-Zhong
Chen, Shao-Liang
author_sort Zhang, Jun-Jie
collection PubMed
description INTRODUCTION: Provisional stenting (PS) for simple coronary bifurcation lesions is the mainstay of treatment. A systematic two-stent approach is widely used for complex bifurcation lesions (CBLs). However, a randomised comparison of PS and two-stent techniques for CBLs has never been studied. Accordingly, the present study is designed to elucidate the benefits of two-stent treatment over PS in patients with CBLs. METHODS AND ANALYSIS: This DEFINITION II study is a prospective, multinational, randomised, endpoint-driven trial to compare the benefits of the two-stent technique with PS for CBLs. A total of 660 patients with CBLs will be randomised in a 1:1 fashion to receive either PS or the two-stent technique. The primary endpoint is the rate of 12-month target lesion failure defined as the composite of cardiac death, target vessel myocardial infarction (MI) and clinically driven target lesion revascularisation. The major secondary endpoints include all causes of death, MI, target vessel revascularisation, in-stent restenosis, stroke and each individual component of the primary endpoints. The safety endpoint is the occurrence of definite or probable stent thrombosis. ETHICS AND DISSEMINATION: The study protocol and informed consent have been approved by the Institutional Review Board of Nanjing First Hospital, and accepted by each participating centre. Written informed consent was obtained from all enrolled patients. Findings of the study will be published in a peer-reviewed journal and disseminated at conferences. TRIAL REGISTRATION NUMBER: NCT02284750; Pre-results.
format Online
Article
Text
id pubmed-5855162
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-58551622018-03-19 Treatment effects of systematic two-stent and provisional stenting techniques in patients with complex coronary bifurcation lesions: rationale and design of a prospective, randomised and multicentre DEFINITION II trial Zhang, Jun-Jie Gao, Xiao-Fei Han, Ya-Ling Kan, Jing Tao, Ling Ge, Zhen Tresukosol, Damras Lu, Shu Ma, Li-Kun Li, Feng Yang, Song Zhang, Jun Munawar, Muhammad Li, Li Zhang, Rui-Yan Zeng, He-Song Santoso, Teguh Xie, Ping Jin, Ze-Ning Han, Leng Yin, Wei-Hsian Qian, Xue-Song Li, Qi-Hua Hong, Lang Paiboon, Chotnoparatpat Wang, Yan Liu, Li-Jun Zhou, Lei Wu, Xue-Ming Wen, Shang-Yu Lu, Qing-Hua Yuan, Jun-Qiang Chen, Liang-Long Lavarra, Francesco Rodríguez, Alfredo E Zhou, Li-Min Ding, Shi-Qin Vichairuangthum, Kitigon Zhu, Yuan-Sheng Yu, Meng-Yue Chen, Chan Sheiban, Imad Xia, Yong Tian, Yu-Long Shang, Zheng-Lu Jiang, Qing Zhen, Yong-Hong Wang, Xin Ye, Fei Tian, Nai-Liang Lin, Song Liu, Zhi-Zhong Chen, Shao-Liang BMJ Open Cardiovascular Medicine INTRODUCTION: Provisional stenting (PS) for simple coronary bifurcation lesions is the mainstay of treatment. A systematic two-stent approach is widely used for complex bifurcation lesions (CBLs). However, a randomised comparison of PS and two-stent techniques for CBLs has never been studied. Accordingly, the present study is designed to elucidate the benefits of two-stent treatment over PS in patients with CBLs. METHODS AND ANALYSIS: This DEFINITION II study is a prospective, multinational, randomised, endpoint-driven trial to compare the benefits of the two-stent technique with PS for CBLs. A total of 660 patients with CBLs will be randomised in a 1:1 fashion to receive either PS or the two-stent technique. The primary endpoint is the rate of 12-month target lesion failure defined as the composite of cardiac death, target vessel myocardial infarction (MI) and clinically driven target lesion revascularisation. The major secondary endpoints include all causes of death, MI, target vessel revascularisation, in-stent restenosis, stroke and each individual component of the primary endpoints. The safety endpoint is the occurrence of definite or probable stent thrombosis. ETHICS AND DISSEMINATION: The study protocol and informed consent have been approved by the Institutional Review Board of Nanjing First Hospital, and accepted by each participating centre. Written informed consent was obtained from all enrolled patients. Findings of the study will be published in a peer-reviewed journal and disseminated at conferences. TRIAL REGISTRATION NUMBER: NCT02284750; Pre-results. BMJ Publishing Group 2018-03-06 /pmc/articles/PMC5855162/ /pubmed/29511018 http://dx.doi.org/10.1136/bmjopen-2017-020019 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Cardiovascular Medicine
Zhang, Jun-Jie
Gao, Xiao-Fei
Han, Ya-Ling
Kan, Jing
Tao, Ling
Ge, Zhen
Tresukosol, Damras
Lu, Shu
Ma, Li-Kun
Li, Feng
Yang, Song
Zhang, Jun
Munawar, Muhammad
Li, Li
Zhang, Rui-Yan
Zeng, He-Song
Santoso, Teguh
Xie, Ping
Jin, Ze-Ning
Han, Leng
Yin, Wei-Hsian
Qian, Xue-Song
Li, Qi-Hua
Hong, Lang
Paiboon, Chotnoparatpat
Wang, Yan
Liu, Li-Jun
Zhou, Lei
Wu, Xue-Ming
Wen, Shang-Yu
Lu, Qing-Hua
Yuan, Jun-Qiang
Chen, Liang-Long
Lavarra, Francesco
Rodríguez, Alfredo E
Zhou, Li-Min
Ding, Shi-Qin
Vichairuangthum, Kitigon
Zhu, Yuan-Sheng
Yu, Meng-Yue
Chen, Chan
Sheiban, Imad
Xia, Yong
Tian, Yu-Long
Shang, Zheng-Lu
Jiang, Qing
Zhen, Yong-Hong
Wang, Xin
Ye, Fei
Tian, Nai-Liang
Lin, Song
Liu, Zhi-Zhong
Chen, Shao-Liang
Treatment effects of systematic two-stent and provisional stenting techniques in patients with complex coronary bifurcation lesions: rationale and design of a prospective, randomised and multicentre DEFINITION II trial
title Treatment effects of systematic two-stent and provisional stenting techniques in patients with complex coronary bifurcation lesions: rationale and design of a prospective, randomised and multicentre DEFINITION II trial
title_full Treatment effects of systematic two-stent and provisional stenting techniques in patients with complex coronary bifurcation lesions: rationale and design of a prospective, randomised and multicentre DEFINITION II trial
title_fullStr Treatment effects of systematic two-stent and provisional stenting techniques in patients with complex coronary bifurcation lesions: rationale and design of a prospective, randomised and multicentre DEFINITION II trial
title_full_unstemmed Treatment effects of systematic two-stent and provisional stenting techniques in patients with complex coronary bifurcation lesions: rationale and design of a prospective, randomised and multicentre DEFINITION II trial
title_short Treatment effects of systematic two-stent and provisional stenting techniques in patients with complex coronary bifurcation lesions: rationale and design of a prospective, randomised and multicentre DEFINITION II trial
title_sort treatment effects of systematic two-stent and provisional stenting techniques in patients with complex coronary bifurcation lesions: rationale and design of a prospective, randomised and multicentre definition ii trial
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855162/
https://www.ncbi.nlm.nih.gov/pubmed/29511018
http://dx.doi.org/10.1136/bmjopen-2017-020019
work_keys_str_mv AT zhangjunjie treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT gaoxiaofei treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT hanyaling treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT kanjing treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT taoling treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT gezhen treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT tresukosoldamras treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT lushu treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT malikun treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT lifeng treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT yangsong treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT zhangjun treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT munawarmuhammad treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT lili treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT zhangruiyan treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT zenghesong treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT santosoteguh treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT xieping treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT jinzening treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT hanleng treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT yinweihsian treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT qianxuesong treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT liqihua treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT honglang treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT paiboonchotnoparatpat treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT wangyan treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT liulijun treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT zhoulei treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT wuxueming treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT wenshangyu treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT luqinghua treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT yuanjunqiang treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT chenlianglong treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT lavarrafrancesco treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT rodriguezalfredoe treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT zhoulimin treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT dingshiqin treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT vichairuangthumkitigon treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT zhuyuansheng treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT yumengyue treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT chenchan treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT sheibanimad treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT xiayong treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT tianyulong treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT shangzhenglu treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT jiangqing treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT zhenyonghong treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT wangxin treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT yefei treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT tiannailiang treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT linsong treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT liuzhizhong treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial
AT chenshaoliang treatmenteffectsofsystematictwostentandprovisionalstentingtechniquesinpatientswithcomplexcoronarybifurcationlesionsrationaleanddesignofaprospectiverandomisedandmulticentredefinitioniitrial