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Is smoking a risk factor for tinnitus? A systematic review, meta-analysis and estimation of the population attributable risk in Germany

OBJECTIVE: To assess the epidemiological association of smoking status and tinnitus with a systematic review and meta-analysis and to estimate the population attributable risk in Germany. DATA SOURCES: A systematic literature search in PubMed and ISI-Web of Science Core Collection resulted in 1026 a...

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Autores principales: Veile, Annette, Zimmermann, Heiko, Lorenz, Eva, Becher, Heiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855477/
https://www.ncbi.nlm.nih.gov/pubmed/29472253
http://dx.doi.org/10.1136/bmjopen-2017-016589
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author Veile, Annette
Zimmermann, Heiko
Lorenz, Eva
Becher, Heiko
author_facet Veile, Annette
Zimmermann, Heiko
Lorenz, Eva
Becher, Heiko
author_sort Veile, Annette
collection PubMed
description OBJECTIVE: To assess the epidemiological association of smoking status and tinnitus with a systematic review and meta-analysis and to estimate the population attributable risk in Germany. DATA SOURCES: A systematic literature search in PubMed and ISI-Web of Science Core Collection resulted in 1026 articles that were indexed until 15 September 2015. Additionally, proceedings of the international tinnitus seminars and reference lists of relevant articles were screened. STUDY SELECTION: Two reviewers searched independently for epidemiological studies. Tinnitus as a manifestation of tumours, vascular malformations, specific syndromes or as a consequence of surgical and medical treatment was not considered. Moreover, studies conducted among patients of ear, nose and throat clinics were excluded. DATA EXTRACTION: If only raw data were provided, effect sizes were calculated. Further unpublished data were received by corresponding authors. DATA SYNTHESIS: Data of 20 studies were pooled. Current smoking (OR 1.21, 95% CI 1.09 to 1.35), former smoking (OR 1.13, 95% CI 1.01 to 1.26) and ever smoking (OR 1.20, 95% CI 1.11 to 1.30) were significantly associated with tinnitus. Moreover, sensitivity analyses for severe tinnitus (OR 1.32, 95% CI 1.10 to 1.58) and for studies of superior quality (OR 1.15, 95% CI 1.03 to 1.29) showed increased risks. According to this, the population attributable risk estimate in Germany is 3.5%. CONCLUSION: There is sufficient evidence that smoking is associated with tinnitus. As the review mainly consists of cross-sectional studies, the observed correlation does not give evidence of a causal relationship. Due to the impact of various confounders, further research is needed to provide more evidence on the strength of association and causal relationships.
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spelling pubmed-58554772018-03-19 Is smoking a risk factor for tinnitus? A systematic review, meta-analysis and estimation of the population attributable risk in Germany Veile, Annette Zimmermann, Heiko Lorenz, Eva Becher, Heiko BMJ Open Epidemiology OBJECTIVE: To assess the epidemiological association of smoking status and tinnitus with a systematic review and meta-analysis and to estimate the population attributable risk in Germany. DATA SOURCES: A systematic literature search in PubMed and ISI-Web of Science Core Collection resulted in 1026 articles that were indexed until 15 September 2015. Additionally, proceedings of the international tinnitus seminars and reference lists of relevant articles were screened. STUDY SELECTION: Two reviewers searched independently for epidemiological studies. Tinnitus as a manifestation of tumours, vascular malformations, specific syndromes or as a consequence of surgical and medical treatment was not considered. Moreover, studies conducted among patients of ear, nose and throat clinics were excluded. DATA EXTRACTION: If only raw data were provided, effect sizes were calculated. Further unpublished data were received by corresponding authors. DATA SYNTHESIS: Data of 20 studies were pooled. Current smoking (OR 1.21, 95% CI 1.09 to 1.35), former smoking (OR 1.13, 95% CI 1.01 to 1.26) and ever smoking (OR 1.20, 95% CI 1.11 to 1.30) were significantly associated with tinnitus. Moreover, sensitivity analyses for severe tinnitus (OR 1.32, 95% CI 1.10 to 1.58) and for studies of superior quality (OR 1.15, 95% CI 1.03 to 1.29) showed increased risks. According to this, the population attributable risk estimate in Germany is 3.5%. CONCLUSION: There is sufficient evidence that smoking is associated with tinnitus. As the review mainly consists of cross-sectional studies, the observed correlation does not give evidence of a causal relationship. Due to the impact of various confounders, further research is needed to provide more evidence on the strength of association and causal relationships. BMJ Publishing Group 2018-02-22 /pmc/articles/PMC5855477/ /pubmed/29472253 http://dx.doi.org/10.1136/bmjopen-2017-016589 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Epidemiology
Veile, Annette
Zimmermann, Heiko
Lorenz, Eva
Becher, Heiko
Is smoking a risk factor for tinnitus? A systematic review, meta-analysis and estimation of the population attributable risk in Germany
title Is smoking a risk factor for tinnitus? A systematic review, meta-analysis and estimation of the population attributable risk in Germany
title_full Is smoking a risk factor for tinnitus? A systematic review, meta-analysis and estimation of the population attributable risk in Germany
title_fullStr Is smoking a risk factor for tinnitus? A systematic review, meta-analysis and estimation of the population attributable risk in Germany
title_full_unstemmed Is smoking a risk factor for tinnitus? A systematic review, meta-analysis and estimation of the population attributable risk in Germany
title_short Is smoking a risk factor for tinnitus? A systematic review, meta-analysis and estimation of the population attributable risk in Germany
title_sort is smoking a risk factor for tinnitus? a systematic review, meta-analysis and estimation of the population attributable risk in germany
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855477/
https://www.ncbi.nlm.nih.gov/pubmed/29472253
http://dx.doi.org/10.1136/bmjopen-2017-016589
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