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Selective Blockade of the Metabotropic Glutamate Receptor mGluR5 Protects Mouse Livers in In Vitro and Ex Vivo Models of Ischemia Reperfusion Injury

2-Methyl-6-(phenylethynyl)pyridine (MPEP), a negative allosteric modulator of the metabotropic glutamate receptor (mGluR) 5, protects hepatocytes from ischemic injury. In astrocytes and microglia, MPEP depletes ATP. These findings seem to be self-contradictory, since ATP depletion is a fundamental s...

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Detalles Bibliográficos
Autores principales:	Ferrigno, Andrea, Berardo, Clarissa, Di Pasqua, Laura Giuseppina, Siciliano, Veronica, Richelmi, Plinio, Nicoletti, Ferdinando, Vairetti, Mariapia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855547/ https://www.ncbi.nlm.nih.gov/pubmed/29360756 http://dx.doi.org/10.3390/ijms19020314

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