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The Molecular Mechanisms of Plant-Derived Compounds Targeting Brain Cancer

Glioblastoma multiforme (GBM) is one of the most aggressive and malignant forms of brain tumors. Despite recent advances in operative and postoperative treatments, it is almost impossible to perform complete resection of these tumors owing to their invasive and diffuse nature. Several natural plant-...

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Autores principales: Fan, Hueng-Chuen, Chi, Ching-Shiang, Chang, Yu-Kang, Tung, Min-Che, Lin, Shinn-Zong, Harn, Horng-Jyh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855617/
https://www.ncbi.nlm.nih.gov/pubmed/29385679
http://dx.doi.org/10.3390/ijms19020395
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author Fan, Hueng-Chuen
Chi, Ching-Shiang
Chang, Yu-Kang
Tung, Min-Che
Lin, Shinn-Zong
Harn, Horng-Jyh
author_facet Fan, Hueng-Chuen
Chi, Ching-Shiang
Chang, Yu-Kang
Tung, Min-Che
Lin, Shinn-Zong
Harn, Horng-Jyh
author_sort Fan, Hueng-Chuen
collection PubMed
description Glioblastoma multiforme (GBM) is one of the most aggressive and malignant forms of brain tumors. Despite recent advances in operative and postoperative treatments, it is almost impossible to perform complete resection of these tumors owing to their invasive and diffuse nature. Several natural plant-derived products, however, have been demonstrated to have promising therapeutic effects, such that they may serve as resources for anticancer drug discovery. The therapeutic effects of one such plant product, n-butylidenephthalide (BP), are wide-ranging in nature, including impacts on cancer cell apoptosis, cell cycle arrest, and cancer cell senescence. The compound also exhibits a relatively high level of penetration through the blood-brain barrier (BBB). Taken together, its actions have been shown to have anti-proliferative, anti-chemoresistance, anti-invasion, anti-migration, and anti-dissemination effects against GBM. In addition, a local drug delivery system for the subcutaneous and intracranial implantation of BP wafers that significantly reduce tumor size in xenograft models, as well as orthotopic and spontaneous brain tumors in animal models, has been developed. Isochaihulactone (ICL), another kind of plant product, possesses a broad spectrum of pharmacological activities, including impacts on cancer cell apoptosis and cell cycle arrest, as well as anti-proliferative and anti-chemoresistance effects. Furthermore, these actions have been specifically shown to have cancer-fighting effects on GBM. In short, the results of various studies reviewed herein have provided substantial evidence indicating that BP and ICH are promising novel anticancer compounds with good potential for clinical applications.
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spelling pubmed-58556172018-03-20 The Molecular Mechanisms of Plant-Derived Compounds Targeting Brain Cancer Fan, Hueng-Chuen Chi, Ching-Shiang Chang, Yu-Kang Tung, Min-Che Lin, Shinn-Zong Harn, Horng-Jyh Int J Mol Sci Review Glioblastoma multiforme (GBM) is one of the most aggressive and malignant forms of brain tumors. Despite recent advances in operative and postoperative treatments, it is almost impossible to perform complete resection of these tumors owing to their invasive and diffuse nature. Several natural plant-derived products, however, have been demonstrated to have promising therapeutic effects, such that they may serve as resources for anticancer drug discovery. The therapeutic effects of one such plant product, n-butylidenephthalide (BP), are wide-ranging in nature, including impacts on cancer cell apoptosis, cell cycle arrest, and cancer cell senescence. The compound also exhibits a relatively high level of penetration through the blood-brain barrier (BBB). Taken together, its actions have been shown to have anti-proliferative, anti-chemoresistance, anti-invasion, anti-migration, and anti-dissemination effects against GBM. In addition, a local drug delivery system for the subcutaneous and intracranial implantation of BP wafers that significantly reduce tumor size in xenograft models, as well as orthotopic and spontaneous brain tumors in animal models, has been developed. Isochaihulactone (ICL), another kind of plant product, possesses a broad spectrum of pharmacological activities, including impacts on cancer cell apoptosis and cell cycle arrest, as well as anti-proliferative and anti-chemoresistance effects. Furthermore, these actions have been specifically shown to have cancer-fighting effects on GBM. In short, the results of various studies reviewed herein have provided substantial evidence indicating that BP and ICH are promising novel anticancer compounds with good potential for clinical applications. MDPI 2018-01-30 /pmc/articles/PMC5855617/ /pubmed/29385679 http://dx.doi.org/10.3390/ijms19020395 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fan, Hueng-Chuen
Chi, Ching-Shiang
Chang, Yu-Kang
Tung, Min-Che
Lin, Shinn-Zong
Harn, Horng-Jyh
The Molecular Mechanisms of Plant-Derived Compounds Targeting Brain Cancer
title The Molecular Mechanisms of Plant-Derived Compounds Targeting Brain Cancer
title_full The Molecular Mechanisms of Plant-Derived Compounds Targeting Brain Cancer
title_fullStr The Molecular Mechanisms of Plant-Derived Compounds Targeting Brain Cancer
title_full_unstemmed The Molecular Mechanisms of Plant-Derived Compounds Targeting Brain Cancer
title_short The Molecular Mechanisms of Plant-Derived Compounds Targeting Brain Cancer
title_sort molecular mechanisms of plant-derived compounds targeting brain cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855617/
https://www.ncbi.nlm.nih.gov/pubmed/29385679
http://dx.doi.org/10.3390/ijms19020395
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