Cargando…
Nanobody Based Dual Specific CARs
Recent clinical trials have shown that adoptive chimeric antigen receptor (CAR) T cell therapy is a very potent and possibly curative option in the treatment of B cell leukemias and lymphomas. However, targeting a single antigen may not be sufficient, and relapse due to the emergence of antigen nega...
Autores principales: | De Munter, Stijn, Ingels, Joline, Goetgeluk, Glenn, Bonte, Sarah, Pille, Melissa, Weening, Karin, Kerre, Tessa, Abken, Hinrich, Vandekerckhove, Bart |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855625/ https://www.ncbi.nlm.nih.gov/pubmed/29385713 http://dx.doi.org/10.3390/ijms19020403 |
Ejemplares similares
-
Rapid and Effective Generation of Nanobody Based CARs using PCR and Gibson Assembly
por: De Munter, Stijn, et al.
Publicado: (2020) -
T-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sources
por: Bonte, Sarah, et al.
Publicado: (2020) -
In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality
por: Bonte, Sarah, et al.
Publicado: (2021) -
Human Thymic CD10(+) PD-1(+) Intraepithelial Lymphocyte Precursors Acquire Interleukin-15 Responsiveness at the CD1a(–) CD95(+) CD28(–) CCR7(–) Developmental Stage
por: Billiet, Lore, et al.
Publicado: (2020) -
Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities
por: Van Caeneghem, Yasmine, et al.
Publicado: (2017)