Cargando…

The Design and Development of Potent Small Molecules as Anticancer Agents Targeting EGFR TK and Tubulin Polymerization

Some novel anthranilate diamides derivatives 4a–e, 6a–c and 9a–d were designed and synthesized to be evaluated for their in vitro anticancer activity. Structures of all newly synthesized compounds were confirmed by infra-red (IR), high-resolution mass (HR-MS) spectra, (1)H nuclear magnetic resonance...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ihmaid, Saleh, Ahmed, Hany E. A., Zayed, Mohamed F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855630/ https://www.ncbi.nlm.nih.gov/pubmed/29385728 http://dx.doi.org/10.3390/ijms19020408

Ejemplares similares

Design, Synthesis, Cytotoxic Evaluation and Molecular Docking of New Fluoroquinazolinones as Potent Anticancer Agents with Dual EGFR Kinase and Tubulin Polymerization Inhibitory Effects
por: Zayed, Mohamed F., et al.
Publicado: (2018)

Design, Synthesis and Cytotoxic Evaluation of Novel Chalcone Derivatives Bearing Triazolo[4,3-a]-quinoxaline Moieties as Potent Anticancer Agents with Dual EGFR Kinase and Tubulin Polymerization Inhibitory Effects
por: Alswah, Mohamed, et al.
Publicado: (2017)

Quinazolinone-Amino Acid Hybrids as Dual Inhibitors of EGFR Kinase and Tubulin Polymerization
por: Zayed, Mohamed F., et al.
Publicado: (2018)

Novel Anticancer Fused Pyrazole Derivatives as EGFR and VEGFR-2 Dual TK Inhibitors
por: Saleh, Nashwa M., et al.
Publicado: (2020)

Novel dermacozine-1-carboxamides as promising anticancer agents with tubulin polymerization inhibitory activity
por: Ghanta, Venkata Rao, et al.
Publicado: (2019)

Self Organizing Map-Based Classification of Cathepsin k and S Inhibitors with Different Selectivity Profiles Using Different Structural Molecular Fingerprints: Design and Application for Discovery of Novel Hits
por: Ihmaid, Saleh K., et al.
Publicado: (2016)

Design and Synthesis of Novel Imidazole Derivatives Possessing Triazole Pharmacophore with Potent Anticancer Activity, and In Silico ADMET with GSK-3β Molecular Docking Investigations
por: Al-blewi, Fawzia, et al.
Publicado: (2021)

Design, Synthesis, Molecular Docking, and Biological Evaluation of Pyrazole Hybrid Chalcone Conjugates as Potential Anticancer Agents and Tubulin Polymerization Inhibitors
por: Alam, Md. Jahangir, et al.
Publicado: (2022)

Design, synthesis, and biological evaluation of novel 5,6,7-trimethoxy quinolines as potential anticancer agents and tubulin polymerization inhibitors
por: Mirzaei, Salimeh, et al.
Publicado: (2020)

Synthesis and Biological Evaluation of Novel Triple-Modified Colchicine Derivatives as Potent Tubulin-Targeting Anticancer Agents
por: Majcher, Urszula, et al.
Publicado: (2018)

Anticancer activity of a novel small molecule tubulin inhibitor STK899704
por: Sakchaisri, Krisada, et al.
Publicado: (2017)

Tubulin-interactive stilbene derivatives as anticancer agents
por: Mikstacka, Renata, et al.
Publicado: (2013)

Design, Synthesis and Biological Investigation of 2-Anilino Triazolopyrimidines as Tubulin Polymerization Inhibitors with Anticancer Activities
por: Romagnoli, Romeo, et al.
Publicado: (2022)

Introducing novel potent anticancer agents of 1H-benzo[f]chromene scaffolds, targeting c-Src kinase enzyme with MDA-MB-231 cell line anti-invasion effect
por: Ahmed, Hany E. A., et al.
Publicado: (2018)

Small molecules targeting Pin1 as potent anticancer drugs
por: Zhang, Jing, et al.
Publicado: (2023)

A QSAR Study on the 4-Substituted Coumarins as Potent Tubulin Polymerization Inhibitors
por: Dinparast, Leila, et al.
Publicado: (2020)

Design and synthesis of novel oridonin analogues as potent anticancer agents
por: Shen, Qing-Kun, et al.
Publicado: (2018)

Potent Small-Molecule Inhibitors Targeting Acetylated Microtubules as Anticancer Agents Against Triple-Negative Breast Cancer
por: Kwon, Ahreum, et al.
Publicado: (2020)

Novel 8-Methoxycoumarin-3-Carboxamides with potent anticancer activity against liver cancer via targeting caspase-3/7 and β-tubulin polymerization
por: Alzamami, Ahmad, et al.
Publicado: (2023)

Physiological regulation of total tubulin and polymerized tubulin in tissues
Publicado: (1977)

Characterization of the Interaction of TZT‐1027, a Potent Antitumor Agent, with Tubulin
por: Natsume, Tsugitaka, et al.
Publicado: (2000)

Design, Synthesis, and Biological Evaluation of Stable Colchicine Binding Site Tubulin Inhibitors as Potential Anticancer Agents
por: Lu, Yan, et al.
Publicado: (2014)

Zampanolide and dactylolide: cytotoxic tubulin-assembly agents and promising anticancer leads
por: Chen, Qiao-Hong, et al.
Publicado: (2014)

New pyridine and chromene scaffolds as potent vasorelaxant and anticancer agents
por: Dawood, Dina H., et al.
Publicado: (2021)

Ethyl acetate extract from marine sponge Hyattella cribriformis exhibit potent anticancer activity by promoting tubulin polymerization as evidenced mitotic arrest and induction of apoptosis
por: Annamalai, Pazhanimuthu, et al.
Publicado: (2015)

Sulfhydryls and the in vitro polymerization of tubulin
Publicado: (1976)

Target Based Designing of Anthracenone Derivatives as Tubulin Polymerization Inhibiting Agents: 3D QSAR and Docking Approach
por: Samad, Abdul, et al.
Publicado: (2014)

Design, synthesis and biological evaluation of novel thiazole-naphthalene derivatives as potential anticancer agents and tubulin polymerisation inhibitors
por: Wang, Guangcheng, et al.
Publicado: (2021)

Design and Discovery of Quinazoline- and Thiourea-Containing Sorafenib Analogs as EGFR and VEGFR-2 Dual TK Inhibitors
por: Sun, Shaofeng, et al.
Publicado: (2017)

Development of Advanced Macrosphelides: Potent Anticancer Agents
por: Paek, Seung-Mann
Publicado: (2015)

Discovery of a series of novel phenylpiperazine derivatives as EGFR TK inhibitors
por: Sun, Juan, et al.
Publicado: (2015)

Synthesis, Modelling, and Anticonvulsant Studies of New Quinazolines Showing Three Highly Active Compounds with Low Toxicity and High Affinity to the GABA-A Receptor
por: Zayed, Mohamed F., et al.
Publicado: (2017)

Taxol binds to polymerized tubulin in vitro
por: Parness, J, et al.
Publicado: (1981)

Preclinical and Early Clinical Development of PTC596, a Novel Small-Molecule Tubulin-Binding Agent
por: Jernigan, Finith, et al.
Publicado: (2021)

Small molecules that target group II introns are potent antifungal agents
por: Fedorova, Olga, et al.
Publicado: (2018)

New Multi-Targeted Antiproliferative Agents: Design and Synthesis of IC261-Based Oxindoles as Potential Tubulin, CK1 and EGFR Inhibitors
por: Fareed, Momen R., et al.
Publicado: (2021)

Drug-Clinical Agent Molecular Hybrid: Synthesis of Diaryl(trifluoromethyl)pyrazoles as Tubulin Targeting Anticancer Agents
por: Hura, Neha, et al.
Publicado: (2018)

Discovery of a Potent PLK1-PBD Small-Molecule Inhibitor as an Anticancer Drug Candidate through Structure-Based Design
por: Zhou, Yunjiang, et al.
Publicado: (2019)

Exploring the Dual Inhibitory Activity of Novel Anthranilic Acid Derivatives towards α-Glucosidase and Glycogen Phosphorylase Antidiabetic Targets: Design, In Vitro Enzyme Assay, and Docking Studies
por: Ihmaid, Saleh
Publicado: (2018)

Synthesis and Biological Evaluation of Small Molecules as Potential Anticancer Multitarget Agents
por: Pla-López, Alberto, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3mluiclsnbkckh4f3v737t7hrs