When Immune Cells Turn Bad—Tumor-Associated Microglia/Macrophages in Glioma

As a substantial part of the brain tumor microenvironment (TME), glioma-associated microglia/macrophages (GAMs) have an emerging role in tumor progression and in controlling anti-tumor immune responses. We review challenges and improvements of cell models and highlight the contribution of this highl...

Descripción completa

Detalles Bibliográficos
Autores principales: Roesch, Saskia, Rapp, Carmen, Dettling, Steffen, Herold-Mende, Christel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855658/
https://www.ncbi.nlm.nih.gov/pubmed/29389898
http://dx.doi.org/10.3390/ijms19020436
_version_ 1783307148346785792
author Roesch, Saskia
Rapp, Carmen
Dettling, Steffen
Herold-Mende, Christel
author_facet Roesch, Saskia
Rapp, Carmen
Dettling, Steffen
Herold-Mende, Christel
author_sort Roesch, Saskia
collection PubMed
description As a substantial part of the brain tumor microenvironment (TME), glioma-associated microglia/macrophages (GAMs) have an emerging role in tumor progression and in controlling anti-tumor immune responses. We review challenges and improvements of cell models and highlight the contribution of this highly plastic cell population to an immunosuppressive TME, besides their well-known functional role regarding glioma cell invasion and angiogenesis. Finally, we summarize first therapeutic interventions to target GAMs and their effect on the immunobiology of gliomas, focusing on their interaction with T cells.
format Online
Article
Text
id pubmed-5855658
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-58556582018-03-20 When Immune Cells Turn Bad—Tumor-Associated Microglia/Macrophages in Glioma Roesch, Saskia Rapp, Carmen Dettling, Steffen Herold-Mende, Christel Int J Mol Sci Review As a substantial part of the brain tumor microenvironment (TME), glioma-associated microglia/macrophages (GAMs) have an emerging role in tumor progression and in controlling anti-tumor immune responses. We review challenges and improvements of cell models and highlight the contribution of this highly plastic cell population to an immunosuppressive TME, besides their well-known functional role regarding glioma cell invasion and angiogenesis. Finally, we summarize first therapeutic interventions to target GAMs and their effect on the immunobiology of gliomas, focusing on their interaction with T cells. MDPI 2018-02-01 /pmc/articles/PMC5855658/ /pubmed/29389898 http://dx.doi.org/10.3390/ijms19020436 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Roesch, Saskia
Rapp, Carmen
Dettling, Steffen
Herold-Mende, Christel
When Immune Cells Turn Bad—Tumor-Associated Microglia/Macrophages in Glioma
title When Immune Cells Turn Bad—Tumor-Associated Microglia/Macrophages in Glioma
title_full When Immune Cells Turn Bad—Tumor-Associated Microglia/Macrophages in Glioma
title_fullStr When Immune Cells Turn Bad—Tumor-Associated Microglia/Macrophages in Glioma
title_full_unstemmed When Immune Cells Turn Bad—Tumor-Associated Microglia/Macrophages in Glioma
title_short When Immune Cells Turn Bad—Tumor-Associated Microglia/Macrophages in Glioma
title_sort when immune cells turn bad—tumor-associated microglia/macrophages in glioma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855658/
https://www.ncbi.nlm.nih.gov/pubmed/29389898
http://dx.doi.org/10.3390/ijms19020436
work_keys_str_mv AT roeschsaskia whenimmunecellsturnbadtumorassociatedmicrogliamacrophagesinglioma
AT rappcarmen whenimmunecellsturnbadtumorassociatedmicrogliamacrophagesinglioma
AT dettlingsteffen whenimmunecellsturnbadtumorassociatedmicrogliamacrophagesinglioma
AT heroldmendechristel whenimmunecellsturnbadtumorassociatedmicrogliamacrophagesinglioma

Ejemplares similares