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Temporomandibular Joint Regenerative Medicine

The temporomandibular joint (TMJ) is an articulation formed between the temporal bone and the mandibular condyle which is commonly affected. These affections are often so painful during fundamental oral activities that patients have lower quality of life. Limitations of therapeutics for severe TMJ d...

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Autores principales: Van Bellinghen, Xavier, Idoux-Gillet, Ysia, Pugliano, Marion, Strub, Marion, Bornert, Fabien, Clauss, Francois, Schwinté, Pascale, Keller, Laetitia, Benkirane-Jessel, Nadia, Kuchler-Bopp, Sabine, Lutz, Jean Christophe, Fioretti, Florence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855668/
https://www.ncbi.nlm.nih.gov/pubmed/29393880
http://dx.doi.org/10.3390/ijms19020446
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author Van Bellinghen, Xavier
Idoux-Gillet, Ysia
Pugliano, Marion
Strub, Marion
Bornert, Fabien
Clauss, Francois
Schwinté, Pascale
Keller, Laetitia
Benkirane-Jessel, Nadia
Kuchler-Bopp, Sabine
Lutz, Jean Christophe
Fioretti, Florence
author_facet Van Bellinghen, Xavier
Idoux-Gillet, Ysia
Pugliano, Marion
Strub, Marion
Bornert, Fabien
Clauss, Francois
Schwinté, Pascale
Keller, Laetitia
Benkirane-Jessel, Nadia
Kuchler-Bopp, Sabine
Lutz, Jean Christophe
Fioretti, Florence
author_sort Van Bellinghen, Xavier
collection PubMed
description The temporomandibular joint (TMJ) is an articulation formed between the temporal bone and the mandibular condyle which is commonly affected. These affections are often so painful during fundamental oral activities that patients have lower quality of life. Limitations of therapeutics for severe TMJ diseases have led to increased interest in regenerative strategies combining stem cells, implantable scaffolds and well-targeting bioactive molecules. To succeed in functional and structural regeneration of TMJ is very challenging. Innovative strategies and biomaterials are absolutely crucial because TMJ can be considered as one of the most difficult tissues to regenerate due to its limited healing capacity, its unique histological and structural properties and the necessity for long-term prevention of its ossified or fibrous adhesions. The ideal approach for TMJ regeneration is a unique scaffold functionalized with an osteochondral molecular gradient containing a single stem cell population able to undergo osteogenic and chondrogenic differentiation such as BMSCs, ADSCs or DPSCs. The key for this complex regeneration is the functionalization with active molecules such as IGF-1, TGF-β1 or bFGF. This regeneration can be optimized by nano/micro-assisted functionalization and by spatiotemporal drug delivery systems orchestrating the 3D formation of TMJ tissues.
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spelling pubmed-58556682018-03-20 Temporomandibular Joint Regenerative Medicine Van Bellinghen, Xavier Idoux-Gillet, Ysia Pugliano, Marion Strub, Marion Bornert, Fabien Clauss, Francois Schwinté, Pascale Keller, Laetitia Benkirane-Jessel, Nadia Kuchler-Bopp, Sabine Lutz, Jean Christophe Fioretti, Florence Int J Mol Sci Review The temporomandibular joint (TMJ) is an articulation formed between the temporal bone and the mandibular condyle which is commonly affected. These affections are often so painful during fundamental oral activities that patients have lower quality of life. Limitations of therapeutics for severe TMJ diseases have led to increased interest in regenerative strategies combining stem cells, implantable scaffolds and well-targeting bioactive molecules. To succeed in functional and structural regeneration of TMJ is very challenging. Innovative strategies and biomaterials are absolutely crucial because TMJ can be considered as one of the most difficult tissues to regenerate due to its limited healing capacity, its unique histological and structural properties and the necessity for long-term prevention of its ossified or fibrous adhesions. The ideal approach for TMJ regeneration is a unique scaffold functionalized with an osteochondral molecular gradient containing a single stem cell population able to undergo osteogenic and chondrogenic differentiation such as BMSCs, ADSCs or DPSCs. The key for this complex regeneration is the functionalization with active molecules such as IGF-1, TGF-β1 or bFGF. This regeneration can be optimized by nano/micro-assisted functionalization and by spatiotemporal drug delivery systems orchestrating the 3D formation of TMJ tissues. MDPI 2018-02-02 /pmc/articles/PMC5855668/ /pubmed/29393880 http://dx.doi.org/10.3390/ijms19020446 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Van Bellinghen, Xavier
Idoux-Gillet, Ysia
Pugliano, Marion
Strub, Marion
Bornert, Fabien
Clauss, Francois
Schwinté, Pascale
Keller, Laetitia
Benkirane-Jessel, Nadia
Kuchler-Bopp, Sabine
Lutz, Jean Christophe
Fioretti, Florence
Temporomandibular Joint Regenerative Medicine
title Temporomandibular Joint Regenerative Medicine
title_full Temporomandibular Joint Regenerative Medicine
title_fullStr Temporomandibular Joint Regenerative Medicine
title_full_unstemmed Temporomandibular Joint Regenerative Medicine
title_short Temporomandibular Joint Regenerative Medicine
title_sort temporomandibular joint regenerative medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855668/
https://www.ncbi.nlm.nih.gov/pubmed/29393880
http://dx.doi.org/10.3390/ijms19020446
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