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Apoptosis: A Target for Anticancer Therapy
Apoptosis, the cell’s natural mechanism for death, is a promising target for anticancer therapy. Both the intrinsic and extrinsic pathways use caspases to carry out apoptosis through the cleavage of hundreds of proteins. In cancer, the apoptotic pathway is typically inhibited through a wide variety...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855670/ https://www.ncbi.nlm.nih.gov/pubmed/29393886 http://dx.doi.org/10.3390/ijms19020448 |
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author | Pfeffer, Claire M. Singh, Amareshwar T. K. |
author_facet | Pfeffer, Claire M. Singh, Amareshwar T. K. |
author_sort | Pfeffer, Claire M. |
collection | PubMed |
description | Apoptosis, the cell’s natural mechanism for death, is a promising target for anticancer therapy. Both the intrinsic and extrinsic pathways use caspases to carry out apoptosis through the cleavage of hundreds of proteins. In cancer, the apoptotic pathway is typically inhibited through a wide variety of means including overexpression of antiapoptotic proteins and under-expression of proapoptotic proteins. Many of these changes cause intrinsic resistance to the most common anticancer therapy, chemotherapy. Promising new anticancer therapies are plant-derived compounds that exhibit anticancer activity through activating the apoptotic pathway. |
format | Online Article Text |
id | pubmed-5855670 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-58556702018-03-20 Apoptosis: A Target for Anticancer Therapy Pfeffer, Claire M. Singh, Amareshwar T. K. Int J Mol Sci Review Apoptosis, the cell’s natural mechanism for death, is a promising target for anticancer therapy. Both the intrinsic and extrinsic pathways use caspases to carry out apoptosis through the cleavage of hundreds of proteins. In cancer, the apoptotic pathway is typically inhibited through a wide variety of means including overexpression of antiapoptotic proteins and under-expression of proapoptotic proteins. Many of these changes cause intrinsic resistance to the most common anticancer therapy, chemotherapy. Promising new anticancer therapies are plant-derived compounds that exhibit anticancer activity through activating the apoptotic pathway. MDPI 2018-02-02 /pmc/articles/PMC5855670/ /pubmed/29393886 http://dx.doi.org/10.3390/ijms19020448 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pfeffer, Claire M. Singh, Amareshwar T. K. Apoptosis: A Target for Anticancer Therapy |
title | Apoptosis: A Target for Anticancer Therapy |
title_full | Apoptosis: A Target for Anticancer Therapy |
title_fullStr | Apoptosis: A Target for Anticancer Therapy |
title_full_unstemmed | Apoptosis: A Target for Anticancer Therapy |
title_short | Apoptosis: A Target for Anticancer Therapy |
title_sort | apoptosis: a target for anticancer therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855670/ https://www.ncbi.nlm.nih.gov/pubmed/29393886 http://dx.doi.org/10.3390/ijms19020448 |
work_keys_str_mv | AT pfefferclairem apoptosisatargetforanticancertherapy AT singhamareshwartk apoptosisatargetforanticancertherapy |