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Novel Bacterial Topoisomerase Inhibitors Exploit Asp83 and the Intrinsic Flexibility of the DNA Gyrase Binding Site

DNA gyrases are enzymes that control the topology of DNA in bacteria cells. This is a vital function for bacteria. For this reason, DNA gyrases are targeted by widely used antibiotics such as quinolones. Recently, structural and biochemical investigations identified a new class of DNA gyrase inhibit...

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Detalles Bibliográficos
Autores principales:	Franco-Ulloa, Sebastian, La Sala, Giuseppina, Miscione, Gian Pietro, De Vivo, Marco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855675/ https://www.ncbi.nlm.nih.gov/pubmed/29401640 http://dx.doi.org/10.3390/ijms19020453

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