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Neutrophils: Beneficial and Harmful Cells in Septic Arthritis
Septic arthritis is an inflammatory joint disease that is induced by pathogens such as Staphylococcus aureus. Infection of the joint triggers an acute inflammatory response directed by inflammatory mediators including microbial danger signals and cytokines and is accompanied by an influx of leukocyt...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855690/ https://www.ncbi.nlm.nih.gov/pubmed/29401737 http://dx.doi.org/10.3390/ijms19020468 |
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author | Boff, Daiane Crijns, Helena Teixeira, Mauro M. Amaral, Flavio A. Proost, Paul |
author_facet | Boff, Daiane Crijns, Helena Teixeira, Mauro M. Amaral, Flavio A. Proost, Paul |
author_sort | Boff, Daiane |
collection | PubMed |
description | Septic arthritis is an inflammatory joint disease that is induced by pathogens such as Staphylococcus aureus. Infection of the joint triggers an acute inflammatory response directed by inflammatory mediators including microbial danger signals and cytokines and is accompanied by an influx of leukocytes. The recruitment of these inflammatory cells depends on gradients of chemoattractants including formylated peptides from the infectious agent or dying cells, host-derived leukotrienes, complement proteins and chemokines. Neutrophils are of major importance and play a dual role in the pathogenesis of septic arthritis. On the one hand, these leukocytes are indispensable in the first-line defense to kill invading pathogens in the early stage of disease. However, on the other hand, neutrophils act as mediators of tissue destruction. Since the elimination of inflammatory neutrophils from the site of inflammation is a prerequisite for resolution of the acute inflammatory response, the prolonged stay of these leukocytes at the inflammatory site can lead to irreversible damage to the infected joint, which is known as an important complication in septic arthritis patients. Thus, timely reduction of the recruitment of inflammatory neutrophils to infected joints may be an efficient therapy to reduce tissue damage in septic arthritis. |
format | Online Article Text |
id | pubmed-5855690 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-58556902018-03-20 Neutrophils: Beneficial and Harmful Cells in Septic Arthritis Boff, Daiane Crijns, Helena Teixeira, Mauro M. Amaral, Flavio A. Proost, Paul Int J Mol Sci Review Septic arthritis is an inflammatory joint disease that is induced by pathogens such as Staphylococcus aureus. Infection of the joint triggers an acute inflammatory response directed by inflammatory mediators including microbial danger signals and cytokines and is accompanied by an influx of leukocytes. The recruitment of these inflammatory cells depends on gradients of chemoattractants including formylated peptides from the infectious agent or dying cells, host-derived leukotrienes, complement proteins and chemokines. Neutrophils are of major importance and play a dual role in the pathogenesis of septic arthritis. On the one hand, these leukocytes are indispensable in the first-line defense to kill invading pathogens in the early stage of disease. However, on the other hand, neutrophils act as mediators of tissue destruction. Since the elimination of inflammatory neutrophils from the site of inflammation is a prerequisite for resolution of the acute inflammatory response, the prolonged stay of these leukocytes at the inflammatory site can lead to irreversible damage to the infected joint, which is known as an important complication in septic arthritis patients. Thus, timely reduction of the recruitment of inflammatory neutrophils to infected joints may be an efficient therapy to reduce tissue damage in septic arthritis. MDPI 2018-02-05 /pmc/articles/PMC5855690/ /pubmed/29401737 http://dx.doi.org/10.3390/ijms19020468 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Boff, Daiane Crijns, Helena Teixeira, Mauro M. Amaral, Flavio A. Proost, Paul Neutrophils: Beneficial and Harmful Cells in Septic Arthritis |
title | Neutrophils: Beneficial and Harmful Cells in Septic Arthritis |
title_full | Neutrophils: Beneficial and Harmful Cells in Septic Arthritis |
title_fullStr | Neutrophils: Beneficial and Harmful Cells in Septic Arthritis |
title_full_unstemmed | Neutrophils: Beneficial and Harmful Cells in Septic Arthritis |
title_short | Neutrophils: Beneficial and Harmful Cells in Septic Arthritis |
title_sort | neutrophils: beneficial and harmful cells in septic arthritis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855690/ https://www.ncbi.nlm.nih.gov/pubmed/29401737 http://dx.doi.org/10.3390/ijms19020468 |
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