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Modulation of Telomerase Activity in Cancer Cells by Dietary Compounds: A Review

Telomerase is expressed in ~90% of human cancer cell lines and tumor specimens, whereas its enzymatic activity is not detectable in most human somatic cells, suggesting that telomerase represents a highly attractive target for selective cancer treatment. Accordingly, various classes of telomerase in...

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Autores principales: Eitsuka, Takahiro, Nakagawa, Kiyotaka, Kato, Shunji, Ito, Junya, Otoki, Yurika, Takasu, Soo, Shimizu, Naoki, Takahashi, Takumi, Miyazawa, Teruo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855700/
https://www.ncbi.nlm.nih.gov/pubmed/29415465
http://dx.doi.org/10.3390/ijms19020478
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author Eitsuka, Takahiro
Nakagawa, Kiyotaka
Kato, Shunji
Ito, Junya
Otoki, Yurika
Takasu, Soo
Shimizu, Naoki
Takahashi, Takumi
Miyazawa, Teruo
author_facet Eitsuka, Takahiro
Nakagawa, Kiyotaka
Kato, Shunji
Ito, Junya
Otoki, Yurika
Takasu, Soo
Shimizu, Naoki
Takahashi, Takumi
Miyazawa, Teruo
author_sort Eitsuka, Takahiro
collection PubMed
description Telomerase is expressed in ~90% of human cancer cell lines and tumor specimens, whereas its enzymatic activity is not detectable in most human somatic cells, suggesting that telomerase represents a highly attractive target for selective cancer treatment. Accordingly, various classes of telomerase inhibitors have been screened and developed in recent years. We and other researchers have successfully found that some dietary compounds can modulate telomerase activity in cancer cells. Telomerase inhibitors derived from food are subdivided into two groups: one group directly blocks the enzymatic activity of telomerase (e.g., catechin and sulfoquinovosyldiacylglycerol), and the other downregulates the expression of human telomerase reverse transcriptase (hTERT), the catalytic subunit of human telomerase, via signal transduction pathways (e.g., retinoic acid and tocotrienol). In contrast, a few dietary components, including genistein and glycated lipid, induce cellular telomerase activity in several types of cancer cells, suggesting that they may be involved in tumor progression. This review summarizes the current knowledge about the effects of dietary factors on telomerase regulation in cancer cells and discusses their molecular mechanisms of action.
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spelling pubmed-58557002018-03-20 Modulation of Telomerase Activity in Cancer Cells by Dietary Compounds: A Review Eitsuka, Takahiro Nakagawa, Kiyotaka Kato, Shunji Ito, Junya Otoki, Yurika Takasu, Soo Shimizu, Naoki Takahashi, Takumi Miyazawa, Teruo Int J Mol Sci Review Telomerase is expressed in ~90% of human cancer cell lines and tumor specimens, whereas its enzymatic activity is not detectable in most human somatic cells, suggesting that telomerase represents a highly attractive target for selective cancer treatment. Accordingly, various classes of telomerase inhibitors have been screened and developed in recent years. We and other researchers have successfully found that some dietary compounds can modulate telomerase activity in cancer cells. Telomerase inhibitors derived from food are subdivided into two groups: one group directly blocks the enzymatic activity of telomerase (e.g., catechin and sulfoquinovosyldiacylglycerol), and the other downregulates the expression of human telomerase reverse transcriptase (hTERT), the catalytic subunit of human telomerase, via signal transduction pathways (e.g., retinoic acid and tocotrienol). In contrast, a few dietary components, including genistein and glycated lipid, induce cellular telomerase activity in several types of cancer cells, suggesting that they may be involved in tumor progression. This review summarizes the current knowledge about the effects of dietary factors on telomerase regulation in cancer cells and discusses their molecular mechanisms of action. MDPI 2018-02-06 /pmc/articles/PMC5855700/ /pubmed/29415465 http://dx.doi.org/10.3390/ijms19020478 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Eitsuka, Takahiro
Nakagawa, Kiyotaka
Kato, Shunji
Ito, Junya
Otoki, Yurika
Takasu, Soo
Shimizu, Naoki
Takahashi, Takumi
Miyazawa, Teruo
Modulation of Telomerase Activity in Cancer Cells by Dietary Compounds: A Review
title Modulation of Telomerase Activity in Cancer Cells by Dietary Compounds: A Review
title_full Modulation of Telomerase Activity in Cancer Cells by Dietary Compounds: A Review
title_fullStr Modulation of Telomerase Activity in Cancer Cells by Dietary Compounds: A Review
title_full_unstemmed Modulation of Telomerase Activity in Cancer Cells by Dietary Compounds: A Review
title_short Modulation of Telomerase Activity in Cancer Cells by Dietary Compounds: A Review
title_sort modulation of telomerase activity in cancer cells by dietary compounds: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855700/
https://www.ncbi.nlm.nih.gov/pubmed/29415465
http://dx.doi.org/10.3390/ijms19020478
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