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Phosphate-Catalyzed Succinimide Formation from Asp Residues: A Computational Study of the Mechanism
Aspartic acid (Asp) residues in proteins and peptides are prone to the non-enzymatic reactions that give biologically uncommon l-β-Asp, d-Asp, and d-β-Asp residues via the cyclic succinimide intermediate (aminosuccinyl residue, Suc). These abnormal Asp residues are known to have relevance to aging a...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855859/ https://www.ncbi.nlm.nih.gov/pubmed/29495268 http://dx.doi.org/10.3390/ijms19020637 |