Cargando…
Plant Mitochondrial Inner Membrane Protein Insertion
During the biogenesis of the mitochondrial inner membrane, most nuclear-encoded inner membrane proteins are laterally released into the membrane by the TIM23 and the TIM22 machinery during their import into mitochondria. A subset of nuclear-encoded mitochondrial inner membrane proteins and all the m...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855863/ https://www.ncbi.nlm.nih.gov/pubmed/29495281 http://dx.doi.org/10.3390/ijms19020641 |
_version_ | 1783307197216718848 |
---|---|
author | Kolli, Renuka Soll, Jürgen Carrie, Chris |
author_facet | Kolli, Renuka Soll, Jürgen Carrie, Chris |
author_sort | Kolli, Renuka |
collection | PubMed |
description | During the biogenesis of the mitochondrial inner membrane, most nuclear-encoded inner membrane proteins are laterally released into the membrane by the TIM23 and the TIM22 machinery during their import into mitochondria. A subset of nuclear-encoded mitochondrial inner membrane proteins and all the mitochondrial-encoded inner membrane proteins use the Oxa machinery—which is evolutionarily conserved from the endosymbiotic bacterial ancestor of mitochondria—for membrane insertion. Compared to the mitochondria from other eukaryotes, plant mitochondria have several unique features, such as a larger genome and a branched electron transport pathway, and are also involved in additional cellular functions such as photorespiration and stress perception. This review focuses on the unique aspects of plant mitochondrial inner membrane protein insertion machinery, which differs from that in yeast and humans, and includes a case study on the biogenesis of Cox2 in yeast, humans, two plant species, and an algal species to highlight lineage-specific similarities and differences. Interestingly, unlike mitochondria of other eukaryotes but similar to bacteria and chloroplasts, plant mitochondria appear to use the Tat machinery for membrane insertion of the Rieske Fe/S protein. |
format | Online Article Text |
id | pubmed-5855863 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-58558632018-03-20 Plant Mitochondrial Inner Membrane Protein Insertion Kolli, Renuka Soll, Jürgen Carrie, Chris Int J Mol Sci Review During the biogenesis of the mitochondrial inner membrane, most nuclear-encoded inner membrane proteins are laterally released into the membrane by the TIM23 and the TIM22 machinery during their import into mitochondria. A subset of nuclear-encoded mitochondrial inner membrane proteins and all the mitochondrial-encoded inner membrane proteins use the Oxa machinery—which is evolutionarily conserved from the endosymbiotic bacterial ancestor of mitochondria—for membrane insertion. Compared to the mitochondria from other eukaryotes, plant mitochondria have several unique features, such as a larger genome and a branched electron transport pathway, and are also involved in additional cellular functions such as photorespiration and stress perception. This review focuses on the unique aspects of plant mitochondrial inner membrane protein insertion machinery, which differs from that in yeast and humans, and includes a case study on the biogenesis of Cox2 in yeast, humans, two plant species, and an algal species to highlight lineage-specific similarities and differences. Interestingly, unlike mitochondria of other eukaryotes but similar to bacteria and chloroplasts, plant mitochondria appear to use the Tat machinery for membrane insertion of the Rieske Fe/S protein. MDPI 2018-02-24 /pmc/articles/PMC5855863/ /pubmed/29495281 http://dx.doi.org/10.3390/ijms19020641 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kolli, Renuka Soll, Jürgen Carrie, Chris Plant Mitochondrial Inner Membrane Protein Insertion |
title | Plant Mitochondrial Inner Membrane Protein Insertion |
title_full | Plant Mitochondrial Inner Membrane Protein Insertion |
title_fullStr | Plant Mitochondrial Inner Membrane Protein Insertion |
title_full_unstemmed | Plant Mitochondrial Inner Membrane Protein Insertion |
title_short | Plant Mitochondrial Inner Membrane Protein Insertion |
title_sort | plant mitochondrial inner membrane protein insertion |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855863/ https://www.ncbi.nlm.nih.gov/pubmed/29495281 http://dx.doi.org/10.3390/ijms19020641 |
work_keys_str_mv | AT kollirenuka plantmitochondrialinnermembraneproteininsertion AT solljurgen plantmitochondrialinnermembraneproteininsertion AT carriechris plantmitochondrialinnermembraneproteininsertion |