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Plant Mitochondrial Inner Membrane Protein Insertion

During the biogenesis of the mitochondrial inner membrane, most nuclear-encoded inner membrane proteins are laterally released into the membrane by the TIM23 and the TIM22 machinery during their import into mitochondria. A subset of nuclear-encoded mitochondrial inner membrane proteins and all the m...

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Autores principales: Kolli, Renuka, Soll, Jürgen, Carrie, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855863/
https://www.ncbi.nlm.nih.gov/pubmed/29495281
http://dx.doi.org/10.3390/ijms19020641
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author Kolli, Renuka
Soll, Jürgen
Carrie, Chris
author_facet Kolli, Renuka
Soll, Jürgen
Carrie, Chris
author_sort Kolli, Renuka
collection PubMed
description During the biogenesis of the mitochondrial inner membrane, most nuclear-encoded inner membrane proteins are laterally released into the membrane by the TIM23 and the TIM22 machinery during their import into mitochondria. A subset of nuclear-encoded mitochondrial inner membrane proteins and all the mitochondrial-encoded inner membrane proteins use the Oxa machinery—which is evolutionarily conserved from the endosymbiotic bacterial ancestor of mitochondria—for membrane insertion. Compared to the mitochondria from other eukaryotes, plant mitochondria have several unique features, such as a larger genome and a branched electron transport pathway, and are also involved in additional cellular functions such as photorespiration and stress perception. This review focuses on the unique aspects of plant mitochondrial inner membrane protein insertion machinery, which differs from that in yeast and humans, and includes a case study on the biogenesis of Cox2 in yeast, humans, two plant species, and an algal species to highlight lineage-specific similarities and differences. Interestingly, unlike mitochondria of other eukaryotes but similar to bacteria and chloroplasts, plant mitochondria appear to use the Tat machinery for membrane insertion of the Rieske Fe/S protein.
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spelling pubmed-58558632018-03-20 Plant Mitochondrial Inner Membrane Protein Insertion Kolli, Renuka Soll, Jürgen Carrie, Chris Int J Mol Sci Review During the biogenesis of the mitochondrial inner membrane, most nuclear-encoded inner membrane proteins are laterally released into the membrane by the TIM23 and the TIM22 machinery during their import into mitochondria. A subset of nuclear-encoded mitochondrial inner membrane proteins and all the mitochondrial-encoded inner membrane proteins use the Oxa machinery—which is evolutionarily conserved from the endosymbiotic bacterial ancestor of mitochondria—for membrane insertion. Compared to the mitochondria from other eukaryotes, plant mitochondria have several unique features, such as a larger genome and a branched electron transport pathway, and are also involved in additional cellular functions such as photorespiration and stress perception. This review focuses on the unique aspects of plant mitochondrial inner membrane protein insertion machinery, which differs from that in yeast and humans, and includes a case study on the biogenesis of Cox2 in yeast, humans, two plant species, and an algal species to highlight lineage-specific similarities and differences. Interestingly, unlike mitochondria of other eukaryotes but similar to bacteria and chloroplasts, plant mitochondria appear to use the Tat machinery for membrane insertion of the Rieske Fe/S protein. MDPI 2018-02-24 /pmc/articles/PMC5855863/ /pubmed/29495281 http://dx.doi.org/10.3390/ijms19020641 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kolli, Renuka
Soll, Jürgen
Carrie, Chris
Plant Mitochondrial Inner Membrane Protein Insertion
title Plant Mitochondrial Inner Membrane Protein Insertion
title_full Plant Mitochondrial Inner Membrane Protein Insertion
title_fullStr Plant Mitochondrial Inner Membrane Protein Insertion
title_full_unstemmed Plant Mitochondrial Inner Membrane Protein Insertion
title_short Plant Mitochondrial Inner Membrane Protein Insertion
title_sort plant mitochondrial inner membrane protein insertion
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855863/
https://www.ncbi.nlm.nih.gov/pubmed/29495281
http://dx.doi.org/10.3390/ijms19020641
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