Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding

Teixobactin is a highly promising antibacterial depsipeptide consisting of four d-amino acids and a rare l-allo-enduracididine amino acid. l-allo-Enduracididine is reported to be important for the highly potent antibacterial activity of teixobactin. However, it is also a key limiting factor in the d...

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Detalles Bibliográficos
Autores principales: Parmar, Anish, Iyer, Abhishek, Prior, Stephen H., Lloyd, Daniel G., Leng Goh, Eunice Tze, Vincent, Charlotte S., Palmai-Pallag, Timea, Bachrati, Csanad Z., Breukink, Eefjan, Madder, Annemieke, Lakshminarayanan, Rajamani, Taylor, Edward J., Singh, Ishwar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855875/
https://www.ncbi.nlm.nih.gov/pubmed/29568465
http://dx.doi.org/10.1039/c7sc03241b

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