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An Improved Method for Magnetic Nanocarrier Drug Delivery across the Cell Membrane
One of the crucial issues in the pharmacological field is developing new drug delivery systems. The main concern is to develop new methods for improving the drug delivery efficiencies such as low disruptions, precise control of the target of delivery and drug sustainability. Nowadays, there are many...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856133/ https://www.ncbi.nlm.nih.gov/pubmed/29382116 http://dx.doi.org/10.3390/s18020381 |
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author | Mehrafrooz, Behzad Pedram, Maysam Z. Ghafar-Zadeh, Ebrahim |
author_facet | Mehrafrooz, Behzad Pedram, Maysam Z. Ghafar-Zadeh, Ebrahim |
author_sort | Mehrafrooz, Behzad |
collection | PubMed |
description | One of the crucial issues in the pharmacological field is developing new drug delivery systems. The main concern is to develop new methods for improving the drug delivery efficiencies such as low disruptions, precise control of the target of delivery and drug sustainability. Nowadays, there are many various methods for drug delivery systems. Carbon-based nanocarriers are a new efficient tool for translocating drug into the defined area or cells inside the body. These nanocarriers can be functionalized with proteins, peptides and used to transport their freight to cells or defined areas. Since functionalized carbon-based nanocarriers show low toxicity and high biocompatibility, they are used in many nanobiotechnology fields. In this study, different shapes of nanocarrier are investigated, and the suitable magnetic field, which is applied using MRI for the delivery of the nanocarrier, is proposed. In this research, based on the force required to cross the membrane and MD simulations, the optimal magnetic field profile is designed. This optimal magnetic force field is derived from the mathematical model of the system and magnetic particle dynamics inside the nanocarrier. The results of this paper illustrate the effects of the nanocarrier’s shapes on the percentage of success in crossing the membrane and the optimal required magnetic field. |
format | Online Article Text |
id | pubmed-5856133 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-58561332018-03-20 An Improved Method for Magnetic Nanocarrier Drug Delivery across the Cell Membrane Mehrafrooz, Behzad Pedram, Maysam Z. Ghafar-Zadeh, Ebrahim Sensors (Basel) Article One of the crucial issues in the pharmacological field is developing new drug delivery systems. The main concern is to develop new methods for improving the drug delivery efficiencies such as low disruptions, precise control of the target of delivery and drug sustainability. Nowadays, there are many various methods for drug delivery systems. Carbon-based nanocarriers are a new efficient tool for translocating drug into the defined area or cells inside the body. These nanocarriers can be functionalized with proteins, peptides and used to transport their freight to cells or defined areas. Since functionalized carbon-based nanocarriers show low toxicity and high biocompatibility, they are used in many nanobiotechnology fields. In this study, different shapes of nanocarrier are investigated, and the suitable magnetic field, which is applied using MRI for the delivery of the nanocarrier, is proposed. In this research, based on the force required to cross the membrane and MD simulations, the optimal magnetic field profile is designed. This optimal magnetic force field is derived from the mathematical model of the system and magnetic particle dynamics inside the nanocarrier. The results of this paper illustrate the effects of the nanocarrier’s shapes on the percentage of success in crossing the membrane and the optimal required magnetic field. MDPI 2018-01-29 /pmc/articles/PMC5856133/ /pubmed/29382116 http://dx.doi.org/10.3390/s18020381 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mehrafrooz, Behzad Pedram, Maysam Z. Ghafar-Zadeh, Ebrahim An Improved Method for Magnetic Nanocarrier Drug Delivery across the Cell Membrane |
title | An Improved Method for Magnetic Nanocarrier Drug Delivery across the Cell Membrane |
title_full | An Improved Method for Magnetic Nanocarrier Drug Delivery across the Cell Membrane |
title_fullStr | An Improved Method for Magnetic Nanocarrier Drug Delivery across the Cell Membrane |
title_full_unstemmed | An Improved Method for Magnetic Nanocarrier Drug Delivery across the Cell Membrane |
title_short | An Improved Method for Magnetic Nanocarrier Drug Delivery across the Cell Membrane |
title_sort | improved method for magnetic nanocarrier drug delivery across the cell membrane |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856133/ https://www.ncbi.nlm.nih.gov/pubmed/29382116 http://dx.doi.org/10.3390/s18020381 |
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