Cargando…

Renal Tubular Cell Mitochondrial Dysfunction Occurs Despite Preserved Renal Oxygen Delivery in Experimental Septic Acute Kidney Injury

OBJECTIVE: To explain the paradigm of significant renal functional impairment despite preserved hemodynamics and histology in sepsis-induced acute kidney injury. DESIGN: Prospective observational animal study. SETTING: University research laboratory. SUBJECTS: Male Wistar rats. INTERVENTION: Using a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Arulkumaran, Nishkantha, Pollen, Sean, Greco, Elisabetta, Courtneidge, Holly, Hall, Andrew M., Duchen, Michael R., Tam, Frederick W. K., Unwin, Robert J., Singer, Mervyn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2018
Materias:	Online Laboratory Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856355/ https://www.ncbi.nlm.nih.gov/pubmed/29293148 http://dx.doi.org/10.1097/CCM.0000000000002937

Ejemplares similares

Sequential Analysis of a Panel of Biomarkers and Pathologic Findings in a Resuscitated Rat Model of Sepsis and Recovery
por: Arulkumaran, Nishkantha, et al.
Publicado: (2017)

Is the inflammasome a potential therapeutic target in renal disease?
por: Turner, Clare M, et al.
Publicado: (2014)

Purinergic signaling in inflammatory renal disease
por: Arulkumaran, Nishkantha, et al.
Publicado: (2013)

P2X(7) receptor antagonism ameliorates renal dysfunction in a rat model of sepsis
por: Arulkumaran, Nishkantha, et al.
Publicado: (2018)

0889. Mitochondrial dysfunction contributes to sepsis-induces acute kidney injury
por: Greco, E, et al.
Publicado: (2014)

Renal Klotho is Reduced in Septic Patients and Pretreatment With Recombinant Klotho Attenuates Organ Injury in Lipopolysaccharide-Challenged Mice
por: Jou-Valencia, Daniela, et al.
Publicado: (2018)

Baicalein protects renal tubular epithelial cells againsthypoxia-reoxygenation injury
por: Chen, Chun, et al.
Publicado: (2018)

Positive correlation between renal tubular flattening and renal tubular injury/interstitial fibrosis in murine kidney disease models
por: TAKAHASHI, Yuki, et al.
Publicado: (2021)

Renal tubular epithelial cells injury induced by mannitol and its potential mechanism
por: Shi, Jinwan, et al.
Publicado: (2018)

The influence of fasudil on renal proximal tubular cell epithelial–mesenchymal transition induced by parathormone
por: Gao, Ziqing, et al.
Publicado: (2017)

Peripheral Neural Detection of Danger–Associated and Pathogen–Associated Molecular Patterns
por: Ackland, Gareth L., et al.
Publicado: (2013)

Renal tubular gen e biomarkers identification based on immune infiltrates in focal segmental glomerulosclerosis
por: Bai, JunYuan, et al.
Publicado: (2022)

Novel lncRNA XLOC_032768 protects against renal tubular epithelial cells apoptosis in renal ischemia–reperfusion injury by regulating FNDC3B/TGF-β1
por: Zhou, Xiangjun, et al.
Publicado: (2020)

Interleukin-22 attenuates renal tubular cells inflammation and fibrosis induced by TGF-β1 through Notch1 signaling pathway
por: Tang, Rong, et al.
Publicado: (2020)

Xenon Protects Against Septic Acute Kidney Injury via miR-21 Target Signaling Pathway*
por: Jia, Ping, et al.
Publicado: (2015)

Immunomodulators in COVID-19: Two Sides to Every Coin
por: Snow, Timothy A. C., et al.
Publicado: (2020)

Use of non-invasive ventilation for patients with COVID-19: a cause for concern?
por: Arulkumaran, Nishkantha, et al.
Publicado: (2020)

Calcium oxalate crystals induces tight junction disruption in distal renal tubular epithelial cells by activating ROS/Akt/p38 MAPK signaling pathway
por: Yu, Lei, et al.
Publicado: (2017)

Early septic insult in neonatal pigs increases serum and urinary soluble Fas ligand and decreases kidney function without inducing significant renal apoptosis
por: Soni, Hitesh, et al.
Publicado: (2016)

Creating complex protocells and prototissues using simple DNA building blocks
por: Arulkumaran, Nishkantha, et al.
Publicado: (2023)

“L'histoire se répète”, one size does not fit all. Author’s reply
por: Snow, Timothy Arthur Chandos, et al.
Publicado: (2021)

Clarithromycin as an immunomodulator in sepsis: still a (IN)CLASS act
por: Snow, Timothy Arthur Chandos, et al.
Publicado: (2022)

0371. Temporal changes in systemic and renal inflammation and histology in a 72-hour rat model of faecal peritonitis
por: Arulkumaran, N, et al.
Publicado: (2014)

3,3′-Diindolylmethane ameliorates renal fibrosis through the inhibition of renal fibroblast activation in vivo and in vitro
por: Xia, Zun-En, et al.
Publicado: (2018)

The utility of CRP with the use of dexamethasone and Tocilizumab in critically ill patients with COVID-19
por: Zacharias, Harry, et al.
Publicado: (2022)

Effect of peritoneal dialysis versus hemodialysis on renal anemia in renal in end-stage disease patients: a meta-analysis
por: Wang, Wan-Ning, et al.
Publicado: (2016)

Sulfasalazine induces mitochondrial dysfunction and renal injury
por: Niknahad, Hossein, et al.
Publicado: (2017)

Inhaled nitric oxide minimally improves oxygenation in COVID-19 related acute respiratory distress syndrome
por: Longobardo, Alessia, et al.
Publicado: (2021)

Steroids in ARDS: more light is being shed
por: Arulkumaran, Nishkantha, et al.
Publicado: (2020)

Dietary zinc modifies diabetic-induced renal pathology in rats
por: Elsaed, Wael M., et al.
Publicado: (2016)

Acute renal involvement in organophosphate poisoning: histological and immunochemical investigations
por: Kaya, Yasemin, et al.
Publicado: (2018)

Cisplatin-induced oxidative stress stimulates renal Fas ligand shedding
por: Soni, Hitesh, et al.
Publicado: (2018)

Potential role of estradiol in ovariectomy-induced derangement of renal endocrine functions
por: El-Gendy, Ahmed A., et al.
Publicado: (2019)

The anti-inflammatory effects of curcumin on renal ischemia-reperfusion injury in rats
por: Zhang, Jiong, et al.
Publicado: (2018)

Protective effect of curcumin on busulfan-induced renal toxicity in male rats
por: Abdollahifar, Mohammad-Amin, et al.
Publicado: (2020)

Role of tRNA derived fragments in renal ischemia–reperfusion injury
por: Li, Dan, et al.
Publicado: (2022)

MicroRNA-21-containing microvesicles from tubular epithelial cells promote cardiomyocyte hypertrophy
por: Di, Jia, et al.
Publicado: (2021)

Morphine enhances renal cell carcinoma aggressiveness through promotes survivin level
por: Ma, Yabing, et al.
Publicado: (2016)

Effect of apigenin on apoptosis induced by renal ischemia/reperfusion injury in vivo and in vitro
por: Wang, Xiao, et al.
Publicado: (2018)

Tamibarotene inhibit the accumulation of fibrocyte and alleviate renal fibrosis by IL-17A
por: Li, Lixi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_2g9lkspkgq3nb3923mfupin1vu